Patents by Inventor Donatien DE ROCHAMBEAU

Donatien DE ROCHAMBEAU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reagents based on a tertiary amine backbone to introduce chemical functionality in nucleic acids and sequence-controlled polymers
    Patent number: 11358937
    Abstract: It is provided an achiral, non-nucleosidic backbone for phosphoramidites that can be inserted with high yields in nucleic acid strands and sequence-controlled oligo(phosphodiester)s through solid phase synthesis (SPS) using a DNA synthesizer. From this backbone, platforms with useful chemical handles were synthesized, further functionalized, transformed into phosphoramidites and attached to nucleic acid strands and sequence-controlled oligo(phosphodiester)s. The backbone is based on a tertiary amine with a 3-6 carbon spacer between the central nitrogen and the two external hydroxyls. The spacer has been optimized to increase coupling yields and stability.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: June 14, 2022
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Hanadi F. Sleiman, Donatien De Rochambeau, Yuanye Sun
  • REAGENTS BASED ON A TERTIARY AMINE BACKBONE TO INTRODUCE CHEMICAL FUNCTIONALITY IN NUCLEIC ACIDS AND SEQUENCE-CONTROLLED POLYMERS
    Publication number: 20210163422
    Abstract: It is provided an achiral, non-nucleosidic backbone for phosphoramidites that can be inserted with high yields in nucleic acid strands and sequence-controlled oligo(phosphodiester)s through solid phase synthesis (SPS) using a DNA synthesizer. From this backbone, platforms with useful chemical handles were synthesized, further functionalized, transformed into phosphoramidites and attached to nucleic acid strands and sequence-controlled oligo(phosphodiester)s. The backbone is based on a tertiary amine with a 3-6 carbon spacer between the central nitrogen and the two external hydroxyls. The spacer has been optimized to increase coupling yields and stability.
    Type: Application
    Filed: August 9, 2019
    Publication date: June 3, 2021
    Inventors: Hanadi F. SLEIMAN, Donatien DE ROCHAMBEAU, Yuanye SUN