Patents by Inventor Dong Cai
Dong Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931208Abstract: The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.Type: GrantFiled: May 20, 2022Date of Patent: March 19, 2024Assignee: BEIJING FRIENDSHIP HOSPITAL, CAPITAL MEDICAL UNIVERSITYInventors: Zhenchang Wang, Wei Zheng, Han Lv, Pengling Ren, Dehong Luo, Linkun Cai, Yawen Liu, Hongxia Yin, Pengfei Zhao, Jing Li, Dong Liu, Erwei Zhao, Tingting Zhang
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Publication number: 20230321626Abstract: Provided is a synthesis apparatus for synthesizing biomacromolecules. The synthesis apparatus includes a feeding apparatus, a recognition apparatus, a reaction apparatus, a sorting device, and a transfer device. The feeding apparatus includes a transporting assembly that can simultaneously transporting biochips. The recognition apparatus recognizes an identification of each biochip on the transporting assembly and feed back an identification information to a control device. The reaction apparatus includes various reaction vessels for performing synthesis reactions on the biochips. The sorting device includes various first sorting assemblies located on a side of the transporting assembly and correspond to the reaction vessels. The first sorting assemblies sort the chips on the transporting assembly to the reaction vessels corresponding to the current synthesis reactions when controlled by the control device. The transfer device transfers the biochips in the reaction vessels to the feeding device.Type: ApplicationFiled: June 12, 2023Publication date: October 12, 2023Inventors: DING-LONG HU, DONG CAI, FENG WANG, MENGZHE SHEN, YONG WANG, XIANG-ER JIANG, JUN WANG, YUE SHEN
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Patent number: 10316058Abstract: A method of extracting biomolecules from live cells comprising: introducing a plurality of magnetized carbon nanotubes (MCNTs) into a live cell, wherein the MCNTs penetrate the cell membrane under a magnetic force; spearing the MCNTs through the cell under the magnetic force, wherein a biomolecule attaches to at least a portion of the MCNTs to form a biomolecule loaded MCNT; removing at least a portion of the biomolecule loaded MCNTs from the cell under the magnetic force; and collecting at least a portion of the biomolecule loaded MCNTs.Type: GrantFiled: August 4, 2015Date of Patent: June 11, 2019Assignee: UNIVERSITY OF HOUSTON SYSTEMInventors: Zhifeng Ren, Dong Cai, Zhen Yang
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Publication number: 20180369140Abstract: A method of selectively targeting a cell with a therapeutic agent, the method comprising: targeting a cell with a nanospear, puncturing the cell with said nanospear; releasing a therapeutic agent from said nanospear, wherein said therapeutic agent enters said cell, thereby effecting the efficacy of said cell.Type: ApplicationFiled: July 9, 2018Publication date: December 27, 2018Inventors: Zhifeng REN, Dong CAI, Jay-Jiguang ZHU
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Patent number: 9846553Abstract: Organization and management of key-value stores is described. An example method includes providing a stack of tables. Each of the tables includes a set of pages of a pre-determined size for storing a set of key-value entries. The method includes monotonically decreasing a number of pages in the tables according to a position of the table in the stack. The method includes configuring each of the pages in the tables to address a particular range of a key space in such a way that each of the pages in a subsequent table in the stack is configured to address a range addressed by at least two pages in a preceding table in the stack. An action with a key-value entry is carried out by starting with a table in the top of the stack and moving to the next table if the action cannot be carried out.Type: GrantFiled: May 4, 2016Date of Patent: December 19, 2017Assignee: Exablox CorporationInventors: Sridhar Subramaniam, Dong Cai
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Publication number: 20170322748Abstract: Organization and management of key-value stores is described. An example method includes providing a stack of tables. Each of the tables includes a set of pages of a pre-determined size for storing a set of key-value entries. The method includes monotonically decreasing a number of pages in the tables according to a position of the table in the stack. The method includes configuring each of the pages in the tables to address a particular range of a key space in such a way that each of the pages in a subsequent table in the stack is configured to address a range addressed by at least two pages in a preceding table in the stack. An action with a key-value entry is carried out by starting with a table in the top of the stack and moving to the next table if the action cannot be carried out.Type: ApplicationFiled: May 4, 2016Publication date: November 9, 2017Inventors: Sridhar Subramaniam, Dong Cai
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Publication number: 20170258714Abstract: A method of selectively targeting a cell with a therapeutic agent, the method comprising: targeting a cell with a nanospear, puncturing the cell with said nanospear; releasing a therapeutic agent from said nanospear, wherein said therapeutic agent enters said cell, thereby effecting the efficacy of said cell.Type: ApplicationFiled: May 1, 2017Publication date: September 14, 2017Applicant: University of Houston SystemInventors: Zhifeng REN, Dong CAI, Jay-Jiguang ZHU
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Publication number: 20170233435Abstract: A method of extracting biomolecules from live cells comprising: introducing a plurality of magnetized carbon nanotubes (MCNTs) into a live cell, wherein the MCNTs penetrate the cell membrane under a magnetic force; spearing the MCNTs through the cell under the magnetic force, wherein a biomolecule attaches to at least a portion of the MCNTs to form a biomolecule loaded MCNT; removing at least a portion of the biomolecule loaded MCNTs from the cell under the magnetic force; and collecting at least a portion of the biomolecule loaded MCNTs.Type: ApplicationFiled: August 4, 2015Publication date: August 17, 2017Inventors: Zhifeng REN, Dong CAI, Zhen YANG
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Patent number: 9360509Abstract: A nanocoaxial sensor includes an outer conductor, an inner conductor, a nanoporous dielectric material disposed between the outer and inner conductors, a nanocavity sized to allow target species to enter the nanocavity between the outer and inner conductors.Type: GrantFiled: March 21, 2012Date of Patent: June 7, 2016Assignee: Trustees of Boston CollegeInventors: Michael J. Naughton, Dong Cai, Binod Rizal, Thomas Chiles, Huaizhou Zhao
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Publication number: 20160146801Abstract: A bio-recognition system is described, where a bio-recognition nanosensor system uses an electropolymerization to produce protein imprints for biomarker recognition. Methods of making a bio-recognition sensor include forming a electropolymer coating on an electrode, binding a target biological structure to the coating to form an imprint, removing the biological structure from the coating, and forming a template that binds a specific biological structure.Type: ApplicationFiled: August 4, 2015Publication date: May 26, 2016Inventors: Dong CAI, Zhifeng REN
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Patent number: 9134305Abstract: An apparatus for detecting the presence of a target molecule is disclosed which includes a conductive nanostructure, a non-conductive polymer coating on at least a portion of the nanostructure, and a cavity formed in the polymer coating having a shape corresponding to the shape of the target molecule. A property of the nanostructure depends on the presence of the target molecule at the cavity.Type: GrantFiled: February 3, 2010Date of Patent: September 15, 2015Assignee: The Trustees of Boston CollegeInventors: Dong Cai, Thomas C. Chiles
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Patent number: 9110055Abstract: A nanocoaxial sensor includes an outer conductor, an inner conductor, a dielectric material disposed between the outer and inner conductors, a nanocavity sized to allow target species to enter the nanocavity between the outer and inner conductors, and an active sensing element immobilized within the nanocavity on at least one of the inner or outer conductors. The active sensing element is adapted to selectively capture the at least one of the target species.Type: GrantFiled: November 16, 2007Date of Patent: August 18, 2015Assignee: The Trustees of Boston CollegeInventors: Dong Cai, Thomas Chiles, Krzysztof Kempa, Michael Naughton, Zhifeng Ren, Paudel Trilochan
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Publication number: 20150031582Abstract: A method comprising (a) obtaining one or more biological samples from a subject wherein the subject has undergone an organ transplant; (b) determining the amount and type of one or more volatile organic compounds in the biological sample; and (c) correlating the amount of volatile organic compounds to a degree of transplant rejection. A device comprising a plurality of sensors configured to detect a plurality of volatile organic compounds in a biological sample of a subject having undergone an organ transplant.Type: ApplicationFiled: July 28, 2014Publication date: January 29, 2015Applicant: UNIVERSITY OF HOUSTON SYSTEMInventors: Dong Cai, Zhifeng Ren, Xian C. Li, Renard L. Thomas
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Publication number: 20140015548Abstract: A nanocoaxial sensor includes an outer conductor, an inner conductor, a nanoporous dielectric material disposed between the outer and inner conductors, a nanocavity sized to allow target species to enter the nanocavity between the outer and inner conductors.Type: ApplicationFiled: March 21, 2012Publication date: January 16, 2014Inventors: Michael J. Naughton, Dong Cai, Binod Rizal, Thomas Chiles, Huaizhou Zhao
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Publication number: 20120118751Abstract: An apparatus for detecting the presence of a target molecule is disclosed which includes a conductive nanostructure, a non-conductive polymer coating on at least a portion of the nanostructure, and a cavity formed in the polymer coating having a shape corresponding to the shape of the target molecule. A property of the nanostructure depends on the presence of the target molecule at the cavity.Type: ApplicationFiled: February 3, 2010Publication date: May 17, 2012Inventors: Dong Cai, Thomas C. Chiles
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Publication number: 20110287977Abstract: A nanocoaxial sensor includes an outer conductor, an inner conductor, a dielectric material disposed between the outer and inner conductors, a nanocavity sized to allow target species to enter the nanocavity between the outer and inner conductors, and an active sensing element immobilized within the nanocavity on at least one of the inner or outer conductors. The active sensing element is adapted to selectively capture the at least one of the target species.Type: ApplicationFiled: November 16, 2007Publication date: November 24, 2011Inventors: Dong Cai, Thomas Chiles, Krzysztof Kempa, Michael Naughton, Zhifeng Ren, Paudel Trilochan
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Patent number: 7935517Abstract: A nanostructured molecular delivery vehicle comprising magnetic materials and configured to receive passenger biomolecules. The application of a an appropriate magnetic field having a gradient orients and drives the vehicle into a biological target, which may comprise cells, cell masses, tissue slices, tissues, etc. Under the control of the magnetic field, these vehicles can penetrate cell membranes. Then, the biomolecules carried by the vehicle can be released into the cells to perform their functions. Using this “nanospearing” technique, unprecendented high transfection efficiency has been achieved in several difficult-to-transfect cells. These include, but are not limited to, Bal 17 cells, ex vivo B cells, primary cultured cortical neurons, etc. This method advances the state of the art, providing an improved technique for the introduction of exogenous molecules to cells, with the clinical applications including, but not being limited to, drug delivery, gene therapy, vaccination, etc.Type: GrantFiled: September 22, 2005Date of Patent: May 3, 2011Assignee: NanoLab, Inc.Inventors: Dong Cai, David L. Carnahan
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Publication number: 20070231908Abstract: A nanostructured molecular delivery vehicle comprising magnetic materials and configured to receive passenger biomolecules. The application of a an appropriate magnetic field having a gradient orients and drives the vehicle into a biological target, which may comprise cells, cell masses, tissue slices, tissues, etc. Under the control of the magnetic field, these vehicles can penetrate cell membranes. Then, the biomolecules carried by the vehicle can be released into the cells to perform their functions. Using this “nanospearing” technique, unprecendented high transfection efficiency has been achieved in several difficult-to-transfect cells. These include, but are not limited to, Bal 17 cells, ex vivo B cells, primary cultured cortical neurons, etc. This method advances the state of the art, providing an improved technique for the introduction of exogenous molecules to cells, with the clinical applications including, but not being limited to, drug delivery, gene therapy, vaccination, etc.Type: ApplicationFiled: September 22, 2005Publication date: October 4, 2007Inventors: Dong Cai, David Carnahan
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Publication number: 20060149034Abstract: The present invention relates to peptides which selectively or preferentially home to areas of a heart. The invention further relates to conjugates of the homing peptides and uses thereof.Type: ApplicationFiled: September 18, 2003Publication date: July 6, 2006Inventors: Jay Edelberg, Dong Cai, Barbara Hempstead
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Patent number: RE49853Abstract: A computer-assisted method to timely provide notifications of treatments, the method including receiving de-identified longitudinal medical records, receiving notification data, identifying anonymized patients that received the treatment, identifying notifications for the treatment that were received by the recipients, determining, for each of the identified notifications, whether the recipient is an anonymized patient identified as having received the treatment, determining, for each of the identified notifications for the treatment determined to be received by a recipient that is an anonymized patient identified as having received the treatment, a time relationship between the time when the treatment was received by the anonymized patient and the time that the notification was received by the recipient that is the anonymized patient, and determining, for each of the anonymized patients that received the treatment, associations between one or more time relationships for notifications received by the anonymizType: GrantFiled: August 22, 2022Date of Patent: February 27, 2024Assignee: IQVIA Inc.Inventors: Yong Cai, Bob Doyle, George Mu, Dong Dai, Emily Zhao, Steven Rosztoczy