Abstract: A B7-H3 antibody or antigen-binding fragment thereof includes a heavy chain variable region including heavy chain complementarity determining regions (HCDRs) and a light chain variable region including light chain complementarity determining regions (LCDRs). The B7-H3 antibody has a predetermined complementarity determining region, thereby specifically binding to a B7-H3 antigen, and being internalized into cells, and being usable as an immune checkpoint inhibitor for various diseases.

Abstract: A smart drilling system includes a terminal configured to map a design space to an actual space and having perforation location information in the design space, a drilling machine including a drill for perforation and configured to perform perforation in the actual space under control of the terminal based on the perforation location information, and a total station configured to acquire location information of a reference point in the actual space for mapping the design space to the actual space and location information of the drilling machine in the actual space, and to transmit the location information of the reference point in the actual space and the location information of the drilling machine to the terminal, wherein the terminal recognizes and displays a perforable region or a perforable point at a current position of the drilling machine.

Abstract: Proposed is a rubber composition for a tire tread, which includes: a solution-polymerized elastomer having a conjugated diene-based monomer unit, a solution-polymerized elastomer having an aromatic vinyl monomer unit and a conjugated diene-based monomer unit, or a combination thereof, at 100 parts by weight; and a plasticizer containing an aromatic petroleum resin and an aliphatic olefin polymer, at 10 to 50 parts by weight. Further, a manufacturing method of the rubber composition for a tire tread is proposed.

Abstract: The present invention relates to a modified polymer having the structure of Formula (I) and Formula (IV): wherein A, R1, R2, R3, a, and n are as described herein and wherein R, R?, R?, x, and k are as described herein and methods for preparation thereof. The present invention also relates to a compound having the structure of Formula (II): wherein A, R1, R2, R3, a, and n are as described herein. The present invention also relates to a process for polymerizing unsaturated hydrocarbon monomers.

Abstract: Embodiments of the present invention provide a functionalized processing aid represented by the following Chemical Formula 1 in which a silane-based compound and a cardanol-derived structure are combined, a preparation method thereof, and a rubber composition including the same: (R1)3Si—R2—Z-(E)n??[Chemical Formula 1] in Chemical Formula 1, the definitions of R1, R2, Z, E, and n are as described in the specification.

Abstract: An embodiment of the present specification provides a rubber composition for a tire tread, comprising: a rubber polymer; a petroleum resin; and a functionalized processing aid, wherein the functionalized processing aid is a bond of a silane-based compound and a cardanol-derived structure, represented by the following formula 1: (R1)3Si—R2—Z-(E)n??[Formula 1] wherein R1, R2, Z, E and n are as defined in the specification, and a method of manufacturing the same.

Abstract: Embodiments of the present invention provide a functionalized processing aid represented by the following Chemical Formula 1 in which a silane-based compound and a cardanol-derived structure are combined, a preparation method thereof, and a rubber composition including the same: (R1)3Si—R2—Z-(E)n??[Chemical Formula 1] in Chemical Formula 1, the definitions of R1, R2, Z, E, and n are as described in the specification.

Abstract: The present invention relates to a modified polymer having the structure of Formula (I) and Formula (IV): wherein A, R1, R2, R3, a, and n are as described herein and wherein R, R?, R?, x, and k are as described herein and methods for preparation thereof. The present invention also relates to a compound having the structure of Formula (II): wherein A, R1, R2, R3, a, and n are as described herein. The present invention also relates to a process for polymerizing unsaturated hydrocarbon monomers.

Abstract: Proposed is a rubber composition for a tire tread, which includes: a solution-polymerized elastomer having a conjugated diene-based monomer unit, a solution-polymerized elastomer having an aromatic vinyl monomer unit and a conjugated diene-based monomer unit, or a combination thereof, at 100 parts by weight; and a plasticizer containing an aromatic petroleum resin and an aliphatic olefin polymer, at 10 to 50 parts by weight. Further, a manufacturing method of the rubber composition for a tire tread is proposed.

Abstract: The present invention relates to a modified polymer having the structure of Formula (I) and Formula (IV): wherein A, R1, R2, R3, a, and n are as described herein and wherein R, R?, R?, x, and k are as described herein and methods for preparation thereof. The present invention also relates to a compound having the structure of Formula (II): wherein A, R1, R2, R3, a, and n are as described herein. The present invention also relates to a process for polymerizing unsaturated hydrocarbon monomers.

Abstract: The present invention relates to a modified polymer having the structure of Formula (I) and Formula (IV): wherein A, R1, R2, R3, a, and n are as described herein and wherein R, R?, R?, x, and k are as described herein and methods for preparation thereof. The present invention also relates to a compound having the structure of Formula (II): wherein A, R1, R2, R3, a, and n are as described herein. The present invention also relates to a process for polymerizing unsaturated hydrocarbon monomers.

Abstract: The present disclosure relates to a two-photon probe for in-vivo imaging, having high selectivity for copper(II) ion, and a method for quantitatively estimating copper(II) on (Cu2+) in vivo using the same. The two-photon probe according to the present disclosure can detect intracellular free copper(II) on for a long period of time with a penetration depth greater than 90 ?m in living cells and tissues without the problems of mistargeting and photobleaching and can quantitatively estimate copper(II) on concentration in vivo using the ratio of blue emission intensity at 400-450 nm and red emission intensity at 550-650 nm.