Abstract: A bioreactor vessel is provided. The bioreactor vessel comprises a bioreactor bag wall having an interior side and an exterior side and an aperture extending from the interior side to the exterior side, wherein the interior side is configured to contact and house a reaction mixture. The bioreactor vessel also comprises a port mounted proximate the aperture, the port including a flange fixedly attached to the bioreactor bag, such that a fluidic seal is maintained along a circumference of the flange. The bioreactor vessel also comprises a plurality of sensors disposed within the port.

Abstract: A sensor may include a sensing element retained within a storage compartment filled with a storage medium, which may also be used as a calibration medium. The sensing element can include a sensing surface located away from the distal end of the sensing element, such that an inactive section of the sensing element can cooperate with a sealing member such as an O-ring to form part of the seal retaining the storage/calibration medium. The sensing element can be extended and retracted from the storage compartment to expose the sensing surface to a process medium, while preserving the storage medium within the storage compartment for post-measurement validation.

Abstract: Compositions and methods for treating and/or reducing risk of development or progression of neuroinflammation and neurodegeneration, comprising HSP60 e.g., for nasal administration, and IGFBPL1, e.g., for nasal, systemic, or ocular, e.g., intravitreal, administration.

Abstract: The present invention relates to the field of chemical industry, and discloses organosilicone micro-mesoporous ultra-low dielectric thin films and preparation methods therefor. A structural formula of a POSS-based organosilane precursor in the thin film is as follows: where n is 12, 16, 18, 20, or 22, and X is CH3 or CH2CH3. The preparation method includes the following steps: dissolving a certain amount of the POSS-based precursor in an organic solvent at a room temperature; adding an appropriate amount of a photoacid generator, after uniformly stirring, spraying a mixed liquid to form a film on a substrate; placing the substrate under a light-emitting diode lamp for irradiating for a preset time after the organic solvent is completely evaporated; then placing the substrate in N,N-dimethylformamide for undergoing a transesterification reaction with fluoroalkyl alcohol for 24-72 h; and washing and drying to obtain the organosilicone micro-mesoporous ultra-low dielectric thin film.

Abstract: Disclosed are various methods for creating optical elements through holographic fabrication. One method includes positioning a reflector in an optical path, disposing a first substrate proximal to the reflector along the optical path, disposing a first photosensitive film on the side of the first substrate facing the reflector, transmitting a light beam at a first polarization from a light source along the optical path, reflecting the light beam off the reflector, wherein the reflected light beam has a second polarization, receiving the reflected light beam through the first film and the first substrate, and applying a liquid crystal layer to the first photosensitive film to reproduce the alignment pattern of the first film on the liquid crystal layer.

Abstract: A sensor may include a sensing element retained within a storage compartment filled with a storage medium, which may also be used as a calibration medium. The sensing element can be moved from a first position in which the sensing element is exposed to the storage compartment, and a second position in which the sensing element can be exposed to a process medium. An actuator mechanism may be configured to engage a portion of the sensor to move the sensing element between the first position and the second position. The actuator mechanism may be controlled by an external system, and may include a rotary actuator such as a servomotor or a stepper motor to move the sensing element between the first position and the second position.

Abstract: The present invention comprises a composition with means to inhibit an autoimmune response and methods for using this composition to treat glaucoma and optic neuropathy.

Abstract: A multi-spectral lens comprises a circular polarizer and a tunable cholesteric filter having an associated reflection band. Incoming light is circularly polarized to one handedness by the circular polarizer, and the tunable cholesteric filter transmits the circularly polarized light and reflects the opposite handedness of the circularly polarized light if within the reflection band of the filter, with the reflection band of the tunable cholesteric filter varying with a control voltage. In a preferred embodiment, a mirror is arranged to receive light transmitted by the tunable cholesteric filter and reflect it back towards the filter with flipped handedness, with the reflected light with flipped handedness that is within the reflection band of the tunable cholesteric filter reflected by the tunable cholesteric filter back toward the mirror. The architecture described effectively converts the reflection band of a tunable cholesteric filter into a tunable bandpass filter for a multi-spectral imaging lens.

Abstract: A multi-spectral lens comprises a circular polarizer and a tunable cholesteric filter having an associated reflection band. Incoming light is circularly polarized to one handedness by the circular polarizer, and the tunable cholesteric filter transmits the circularly polarized light and reflects the opposite handedness of the circularly polarized light if within the reflection band of the filter, with the reflection band of the tunable cholesteric filter varying with a control voltage. In a preferred embodiment, a mirror is arranged to receive light transmitted by the tunable cholesteric filter and reflect it back towards the filter with flipped handedness, with the reflected light with flipped handedness that is within the reflection band of the tunable cholesteric filter reflected by the tunable cholesteric filter back toward the mirror. The architecture described effectively converts the reflection band of a tunable cholesteric filter into a tunable bandpass filter for a multi-spectral imaging lens.

Abstract: A colorimetric analyzer includes a reaction chamber configured to receive a sample and at least one reagent. A measurement cell is operably coupled to the reaction chamber. The measurement cell has an illumination source and an illumination detector spaced from the illumination source such that illumination from the illumination source passes through the reacted sample to the illumination detector. A controller is coupled to the illumination source and the illumination detector. The controller is configured to generate an analytic output based on a signal from the illumination detector. A fill conduit is operably interposed between the reaction chamber and the measurement cell. The fill conduit is configured to reduce bubbles.

Abstract: Disclosed is a method of promoting neuronal growth by administering IGFBPL-1, or an agent that increases or stabilizes IGFBPL-1 activity to a subject in need thereof, e.g., a subject in need of treating optic nerve degeneration.

Abstract: The present invention relates to the field of chemical industry, and discloses organosilicone micro-mesoporous ultra-low dielectric thin films and preparation methods therefor. A structural formula of a POSS-based organosilane precursor in the thin film is as follows: where n is 12, 16, 18, 20, or 22, and X is CH3 or CH2CH3. The preparation method includes the following steps: dissolving a certain amount of the POSS-based precursor in an organic solvent at a room temperature; adding an appropriate amount of a photoacid generator, after uniformly stirring, spraying a mixed liquid to form a film on a substrate; placing the substrate under a light-emitting diode lamp for irradiating for a preset time after the organic solvent is completely evaporated; then placing the substrate in N,N-dimethylformamide for undergoing a transesterification reaction with fluoroalkyl alcohol for 24-72 h; and washing and drying to obtain the organosilicone micro-mesoporous ultra-low dielectric thin film.

Abstract: A battery system is provided, including a processing module and a plurality of battery modules. Each of the plurality of battery modules includes a battery management system and an electrochemical cell pack controlled by the battery management system. The processing module is configured to control the electrochemical cell pack to alternately perform a discharging or charging operation. A sum of power of battery modules other than a first battery module in the plurality of battery modules is greater than power required by a target power-supplied object, and the first battery module is any one of the plurality of battery modules. A battery management system is configured to record a target time. The processing module or the battery management system is configured to determine a state of health of the electrochemical cell pack in the first battery module based on the target time.

Abstract: Methods, systems, and devices are provided for assessing visual function, especially in animals. For example, a device can be used for assessing visual functions, such as PLR and OMR, in animals that includes a visual stimulus unit. The device can also include one or more input devices that include at least one camera that is configured to monitor movement of the test subject and a processor that is configured to analyze the movement of the test subject taken by the camera and to assess visual functions of the test subject. The device can be used in a system including a designated general location for the test subject in which the test subject can see the visual stimulus unit and move freely while being monitored by the camera.

Abstract: The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.

Abstract: The invention provides compositions and methods for treating optic neuropathic disorders.

Abstract: Disclosed is a method of promoting neuronal growth by administering IGFBPL-1, or an agent that increases or stabilizes IGFBPL-1 activity to a subject in need thereof, e.g., a subject in need of treating optic nerve degeneration.

Abstract: A method of manufacturing a System in Package (SiP) module includes: welding required electronic units by the SiP module onto a top surface of a Printed Circuit Board (PCB), with welding spots being reserved on a bottom surface of the PCB for obtaining a PCB assembly (PCBA) of the SiP module; pasting tightly a functional film on a surface of the electronic units of the PCBA; filling on plastic materials on the top surface of the PCBA, ensuring that the plastic materials covers the electronic units and the functional film on the top surface of the PCBA, and obtaining solidified PCBA after the plastic materials are solidified; and cutting the solidified PCBA for obtaining a plurality of the SiP modules.

Abstract: A colorimetric wet chemistry analyzer for determining a concentration of an analyte of interest in a sample is provided. The analyzer comprising includes a reaction chamber configured to receive the sample and facilitate a reaction that changes a color of the sample based on the concentration of the analyte of interest. A photometric cell is operably coupled to the reaction chamber to receive the sample and direct illumination therethrough. The photometric cell has a first illumination source configured to provide illumination at a first wavelength through the photometric cell and a second illumination source configured to provide illumination at a second wavelength through the photometric cell. The second wavelength is different than the first wavelength. A photo detector is configured to detect illumination passing through the photometric cell.

Abstract: The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.