Abstract: The present disclosure provides an N protein epitope mutation marker for preparing an epitope deletion-marked vaccine strain of type II porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof, belonging to the technical field of biological products. In the mutation marker, one or more amino acids are mutated based on an epitope sequence at positions 92 to 103 of a C-terminal of an N protein of the type II PRRSV; and the epitope mutation marker has an amino acid sequence shown in SEQ ID NO: 1, where X1 is selected from the group consisting of T, P, and A; and X2 is selected from the group consisting of V and A.

Abstract: A rapid detection device for multi-channel sporadic transient partial discharge, comprising a CPU and several partial discharge detection circuits. The partial discharge detection circuits are connected to a plurality of ports of the CPU one to one, respectively. First, a partial discharge pulse signal is filtered and amplified by means of a partial discharge pulse signal processing module in the partial discharge detection circuits, and is then inputted to a comparator, and a reference voltage passes through the CPU and is sent to a reference voltage processing module for amplification, filtering and other processing, and then is inputted to the comparator, so that the comparator processes same according to the partial discharge pulse signal and the reference voltage and then inputs same to a trigger. Finally, according to a level signal at an output terminal of the trigger, the CPU determines whether partial discharge occurs in a circuit to be detected.

Abstract: The invention provides compositions and in vivo, ex vivo and in vitro methods for trans-differentiation of or re-programming mammalian cells to functional neurons. In particular, the invention provides methods for engineering non-neuronal cells into neurons, including fully functional human neuronal cells, and methods for engineering non-neuronal cells into neurons, e.g., fully functional human neuronal cells, in the brain to treat a neurodegenerative disease. In alternative embodiments, the invention provides compositions comprising re-differentiated or re-programmed mammalian cells, such as human cells, of the invention. The invention also provides compositions and methods for direct reprogramming of cells to a second phenotype or differentiated phenotype, such as a neuron, including a fully functional human neuronal cell.

Abstract: Provided herein is a method of reprogramming a non-neuronal cell to a neuron. Aspects of the present disclosure relate to using cell reprogramming agent suppresses the expression or activity of PTB to convert a non-neuronal cell into a neuron. Also provided herein is a method of treating neurodegenerative disease by reprogramming non-neuronal cells in vivo to functional neurons.

Abstract: The present disclosure relates to an electroluminescent material ink, comprising a quantum dot material, an organic light emitting material, and an organic solvent. The organic solvent includes a first solvent shown in general formula (I): wherein R0 is CmH2m+1; R1, R2, R3, and R4 are each independently CnH2n+1, 0?m?8 and 0<n?8, or 0<m?8 and 0?n?8. The electroluminescent material ink has good physical parameters and can effectively prevent nozzle blockage.

Abstract: An ultrasonic sensing device includes a housing, a piezoelectric assembly, a board and a plurality of fixing members. The housing includes a connecting board being a metal board and a supporting shell being a plastic member. The supporting shell includes a bottom wall opposite to a disposing opening of the connecting board and a surrounding side wall integrally surrounding and connecting to the bottom wall. The surrounding side wall encloses a portion of the connecting board. The piezoelectric assembly includes an encapsulating body and a piezoelectric sheet enclosed by the encapsulating body. The encapsulating body is disposed on the bottom wall and surrounded by the surrounding side wall. The piezoelectric sheet has a sensing surface exposed to the encapsulating body and facing the bottom wall. The fixing members fix the board on the connecting board, thereby pressing the sensing surface of the piezoelectric sheet to the bottom wall.

Abstract: The present disclosure relates to a display panel and a manufacturing method thereof, and a display device. The display panel includes a plurality of pixel units. The pixel unit includes a red sub-pixel, a green sub-pixel and a blue sub-pixel. The red sub-pixel, the green sub-pixel and the blue sub-pixel each include a cathode, an electron transport layer, a quantum dot luminescent layer, a hole function layer and an anode that are stacked. The electron transport layer is made of Mg-doped ZnO nanoparticles, and a Mg doping concentration in the electron transport layer of the red sub-pixel, a Mg doping concentration in the electron transport layer of the green sub-pixel and a Mg doping concentration in the electron transport layer of the blue sub-pixel decrease successively.

Abstract: Provided herein are compositions and methods for reprogramming a non-neuronal cell to a neuron. Aspects of the present disclosure relate to compositions and methods for transdifferentiating an age-restricted non-neuronal cell into a neuron. Also provided herein is a method of treating neurodegenerative disease by reprogramming region or anatomy specific non-neuronal cells into specific types of functionalized neurons.

Abstract: Systems and methods for designing and optimizing tools are provided. A computational fluid dynamics (CFD) simulation model implemented by a processor is provided to simulate a fluid flow inside the tool to generate a particle density distribution of fluids inside the tool. The particle density distribution is converted to a spatial distribution of fluid concentration of the mixture which allows for high resolution visualization of fluid flow in the tool.

Abstract: An ultrasonic sensing device includes a housing, a piezoelectric assembly, a board and a plurality of fixing members. The housing includes a bottom wall, a top wall and a surrounding side wall connected between the top wall and the bottom wall. The piezoelectric assembly includes an encapsulating body and a piezoelectric sheet, wherein at least a portion of the piezoelectric sheet is enclosed by the encapsulating body and has a sensing surface exposed to the encapsulating body and facing the bottom wall. The board is disposed on the top wall of the housing and has a pressing surface facing the encapsulating body and the top wall. The plurality of fixing members is configured to fix the board to the top wall of the housing to press the board to the encapsulating body of the piezoelectric assembly, thereby pressing the sensing surface of the piezoelectric sheet to the bottom wall.

Abstract: An electroluminescent device and a light-emitting layer and an application thereof. The light-emitting layer comprises at least one nano-crystalline semiconductor material and at least one exciplex; an emission spectrum of the exciplex is at least partially overlapped with an excitation spectrum of the nano-crystalline semiconductor material; and the attenuation life of an excited state of the exciplex is longer than the attenuation life of an excited state of the nano-crystalline semiconductor material.

Abstract: The pixel structure includes a plurality of blue pixel sets, a plurality of yellow pixel sets, a first film filter, and a second film filter; the blue pixel set is composed of a plurality of blue sub-pixels arranged in a longitudinal direction, and the yellow pixel set is composed of a plurality of yellow sub-pixels arranged in the longitudinal direction; one blue pixel group and one yellow pixel group adjacent to each other in a horizontal direction constitute a hybrid pixel group, and a plurality of hybrid pixel sets are arranged in a transverse direction; in the hybrid pixel group, each blue sub-pixel is adjacent to at least two of the plurality of yellow sub-pixels, and the blue sub-pixel and at least two adjacent yellow sub-pixels constitute one pixel unit.

Abstract: Disclosed are a pixel structure and a display panel. The pixel structure includes a plurality of pixel units, each pixel unit is in a shape of a rectangle, the pixel unit includes four sub-pixels, respectively one first sub-pixel, two second sub-pixels, and one third sub-pixel, the two second sub-pixels are connected by a sharing edge to form one second sub-pixel unit, the first sub-pixel and the third sub-pixel are respectively provided on opposite sides of the second sub-pixel unit. The pixel structure and the display panel provided by the present disclosure have a high resolution.

Abstract: An ultrasonic sensing apparatus includes an accommodating shell and at least one detection device. The accommodating shell includes a base and a convex portion connected to the base. A side of the base has a first detection opening toward a first direction, and a side of the convex portion has a second detection opening toward a second direction. Each of the at least one detection device is disposed in the base or the convex portion of the accommodating shell and includes a board, a piezoelectric assembly, a housing and a plurality of fixing members. The plurality of fixing members are configured to fix the board on the top wall of the housing to press the board to the encapsulating body of the piezoelectric assembly, thereby pressing the piezoelectric sheet to the bottom wall.

Abstract: A method to detect chromatin-interacting RNAs in any given state of a cell or tissue by examining global RNA interactions with DNA by deep sequencing. A method to generate a global view of chromatin-RNA interactome by mapping the binding locations on the genome of each detected chromatin interacting RNA.

Abstract: An ultrasonic sensing device includes a housing, a piezoelectric assembly, a board and a plurality of fixing members. The housing includes a connecting board being a metal board and a supporting shell being a plastic member. The supporting shell includes a bottom wall opposite to a disposing opening of the connecting board and a surrounding side wall integrally surrounding and connecting to the bottom wall. The surrounding side wall encloses a portion of the connecting board. The piezoelectric assembly includes an encapsulating body and a piezoelectric sheet enclosed by the encapsulating body. The encapsulating body is disposed on the bottom wall and surrounded by the surrounding side wall. The piezoelectric sheet has a sensing surface exposed to the encapsulating body and facing the bottom wall. The fixing members fix the board on the connecting board, thereby pressing the sensing surface of the piezoelectric sheet to the bottom wall.

Abstract: An ultrasonic sensing apparatus includes an accommodating shell and at least one detection device. The accommodating shell includes a base and a convex portion connected to the base. A side of the base has a first detection opening toward a first direction, and a side of the convex portion has a second detection opening toward a second direction. Each of the at least one detection device is disposed in the base or the convex portion of the accommodating shell and includes a board, a piezoelectric assembly, a housing and a plurality of fixing members. The plurality of fixing members are configured to fix the board on the top wall of the housing to press the board to the encapsulating body of the piezoelectric assembly, thereby pressing the piezoelectric sheet to the bottom wall.

Abstract: An ultrasonic sensing device includes a housing, a piezoelectric assembly, a board and a plurality of fixing members. The housing includes a bottom wall, a top wall and a surrounding side wall connected between the top wall and the bottom wall. The piezoelectric assembly includes an encapsulating body and a piezoelectric sheet, wherein at least a portion of the piezoelectric sheet is enclosed by the encapsulating body and has a sensing surface exposed to the encapsulating body and facing the bottom wall. The board is disposed on the top wall of the housing and has a pressing surface facing the encapsulating body and the top wall. The plurality of fixing members is configured to fix the board to the top wall of the housing to press the board to the encapsulating body of the piezoelectric assembly, thereby pressing the sensing surface of the piezoelectric sheet to the bottom wall.

Abstract: Provided herein is a method of reprogramming a non-neuronal cell to a neuron. Aspects of the present disclosure relate to using cell reprogramming agent suppresses the expression or activity of PTB to convert a non-neuronal cell into a neuron. Also provided herein is a method of treating neurodegenerative disease by reprogramming non-neuronal cells in vivo to functional neurons.

Abstract: The present disclosure relates to an electroluminescent material ink, comprising a quantum dot material, an organic light emitting material, and an organic solvent. The organic solvent includes a first solvent shown in general formula (I): wherein R0 is CmH2m+1; R1, R2, R3, and R4 are each independently CnH2n+1, 0?m?8 and 0<n?8, or 0<m?8 and 0?n?8. The electroluminescent material ink has good physical parameters and can effectively prevent nozzle blockage.