Abstract: A dendritic cell (DC)-targeting M13 phage vaccine platform is provided herewith, where spy-tagged neoantigens can be attached to the phage surface with spy-catchers. By expressing DC-targeting peptides and spy-catchers as foreign antigens on the phage surface, its therapeutic and antigenic properties can be enhanced to combat solid cancers. SLS-spy catcher phage (SCP), with or without neoantigen conjugation, significantly repressed tumour growth by boosting systemic anti-tumour immunity and increasing intratumoral infiltration of both innate and adaptive immune cells. Intratumoral administration of SCP also hugely reduced PDL1 expression on tumour cells, making them more susceptible to immune attacks. Additionally, SCP administration restricted the size of blood vessels inside the tumour mass, suggesting multiple factors contribute to restrict tumour growth.

Abstract: A mask frame, comprises a central conduit connection aperture and lateral arms having a 3-D curvature. The lateral arms extend: outwardly from a center of the frame, rearwardly, towards the patients ears, and upwardly, along a vector passing from below the nose to a point between the temple the top of the ear. The lateral arms “twist” along their length, such that a bottom margin of an end of each lateral arm is positioned further away from a notional vertical plane passing through the centre of the conduit connection aperture than a top margin. Also provided is an anti-rotation feature which limits or prevents rotation between straps of a headgear, and the mask frame. Further provided is a buckle for a closed loop headgear the buckle being formed with a plurality of openings and posts configured to form an angled headgear strap path through the buckle through which part of a headgear strap loop can pass.

Abstract: An interface and headgear assembly includes a headgear assembly. The headgear assembly has a first strap configured to connect to the interface. A crown strap can be adjusted along a length of the first strap. In some configurations, the crown strap has a first portion and a second portion that are adjustably connected. The crown strap can be removably connected to the first strap using bridge regions of the first portion and the second portion.

Abstract: A patient interface has a single loop head strap and a mask for covering at least the nostrils of the user. The single loop head strap extends from the mask at either end. A short length of supple conduit is coupled to the mask by a swivel or ball joint to allow rotation of the conduit relative to the mask through different angles and orientations.

Abstract: A monitoring equipment, a monitoring system and a monitoring method. The monitoring equipment includes a measurement unit that acquires monitoring parameters and a control unit connected with the measurement unit to determine current stage-of-labor progress based on types of acquired monitoring parameters, to thereby determine a monitoring object that includes a mother and a fetus and/or a newborn. A display unit is connected with the control unit to display corresponding monitoring parameters in areas corresponding to each monitoring object on a monitoring interface. The monitoring interface includes one or a plurality of a mother monitoring area, a fetus monitoring area and a newborn monitoring area. The measurement unit is provided in the monitoring equipment. The control unit determines the current stage-of-labor progress to determine a monitoring object.

Abstract: A patient interface has a single loop headstrap and a mask for covering at least the nostrils of the user. The single loop headstrap extends from the mask at either end. A short length of supple conduit is coupled to the mask by a swivel or ball joint to allow rotation of the conduit relative to the mask through different angles and orientations.

Abstract: A patient interface has a single loop headstrap and a mask for covering at least the nostrils of the user. The single loop headstrap extends from the mask at either end. A short length of supple conduit is coupled to the mask by a swivel or ball joint to allow rotation of the conduit relative to the mask through different angles and orientations.

Abstract: A patient interface has a single loop headstrap and a mask for covering at least the nostrils of the user. The single loop headstrap extends from the mask at either end. A short length of supple conduit is coupled to the mask by a swivel or ball joint to allow rotation of the conduit relative to the mask through different angles and orientations.

Abstract: The invention relates to RO water purifier (100) with provision for dispensing hot or cold water. The device has a user-interface through which a user can choose how hot the purified water should be. The RO water purifier (100) comprises a compartment (9) for storage of pre-heated or pre-cooled purified water. The compartment comprises an inlet for return of any undispensed purified hot, cold, or ambient water to flow back from the user-interface. The compartment has an outlet for pre-heated or pre-cooled purified water to flow out into a device (8) for heating or cooling it further as desired by the user. The device for heating or cooling the purified ambient water is configured to heat the water to 80 to 95° C. or alternatively, is configured to cool it to 15 to 5° C., and wherein in said e compartment said pre-heated water is stored at 40 to 75° C. and when it is pre, cooled it is stored at 10 to 20° C., and wherein temperature of said purified ambient water is 25 to 40° C.

Abstract: A dual-clutch assembly is provided. The dual-clutch assembly includes a first rotating shaft, a second rotating shaft, a hollow shaft, a first clutch, and a second clutch. The first rotating shaft and the second rotating shaft are arranged coaxially at intervals, and the hollow shaft is sleeved outside the second rotating shaft. The first clutch is between the first rotating shaft and the second rotating shaft, a driving part of the first clutch is connected with the first rotating shaft, and a driven part of the first clutch is connected with the second rotating shaft. A driving part of the second clutch is positioned on one side of the first clutch which is away from the second rotating shaft, and is connected with the first rotating shaft, and a driven part of the second clutch is connected with the hollow shaft.

Abstract: A respiratory mask system includes a mask interface and a headgear assembly. The headgear assembly is adjustable and comprised of an elastic portion, a non-elastic portion and a restriction mechanism configured to provide a force resisting movement of the non-elastic portion when the elastic portion is extended. There is a support beam coupled to the non-elastic portion and extending along a portion of the headgear that is curved along its longitudinal extent. In this way particular seal modules can be comfortably fitted to a user and any blow off force is mitigated. A particular example of the respiratory mask system includes provision for removable attachment between the seal and a mask frame, the mask frame and a yoke of the headgear; and between a conduit and the mask frame.

Abstract: A patient interface includes a frame, an inflatable seal, and a deformable insert. The frame includes an outer portion, an inner portion, and an opening extending therebetween. The inflatable seal is secured to the inner portion of the frame. The inflatable seal defines an internal volume and has at least one aperture. The deformable insert includes an outer surface, an inner surface and a passageway extending therebetween. The deformable insert is positioned within the internal volume of the seal and aligned with at least a portion of the frame inner portion. The passageway is aligned with the frame opening to define a gas flow path from the frame outer portion to the at least one aperture of the seal.

Abstract: A fan and a motor assembly. The motor assembly includes an electric motor with an output shaft defining a rotational axis, an impeller coupled to the output shaft for co-rotation therewith, an adapter positioned between the output shaft and the impeller, and an elastic member positioned between the adapter and the impeller. The elastic member is configured to be compressed by the impeller in response to installation of the impeller upon the adapter, from an undeformed state to an elastically deformed state, in which the elastic member is compressed in a direction of the rotational axis.

Abstract: The present application provides a hybrid power system and a vehicle. The hybrid power system includes a gearbox, an engine, a first motor, and a second motor; wherein the gearbox includes a first input shaft, an output shaft, a second input shaft, a first speed change mechanism, and a second speed change mechanism, wherein the first input shaft is connected to the output shaft via the first speed change mechanism, and the second input shaft is connected to the output shaft via the second speed change mechanism; the engine and the first motor are drivingly connected to the first input shaft; and the second motor is drivingly connected to the second input shaft.

Abstract: A patient interface has a single loop headstrap and a mask for covering at least the nostrils of the user. The single loop headstrap extends from the mask at either end. A short length of supple conduit is coupled to the mask by a swivel or ball joint to allow rotation of the conduit relative to the mask through different angles and orientations.

Abstract: A package structure and a method of manufacturing the same are provided. The method of manufacturing the package structure includes several steps as follows. A lead frame is provided. A first mask layer is formed on an upper surface of the lead frame and a second mask layer is formed on a lower surface of the lead frame, so that the first mask layer, the lead frame and the second mask layer are formed together to be a multilayered structure. A patterning process is performed on the multilayered structure, so a through hole penetrating through the multilayered structure is formed. A sandblasting process is performed in the through hole to form a rough textured surface in the through hole. After that, the first mask layer and the second mask layer are removed to expose the upper surface and the lower surface of the lead frame.

Abstract: A video processing method, apparatus, and device and a storage medium are provided. The method includes: monitoring an operation indication inputted by a user through a personal homepage on a social platform, the personal homepage being used for displaying personal information of the user; obtaining, when the operation indication is a shooting indication for shooting a personal status video, the personal status video; uploading the personal status video to a back-end server of the social platform; and displaying indication information of the personal status video in a personal-information display region of the personal homepage.