Abstract: Provided is a new solid oxygen ionic conductor based field-effect transistor and its manufacturing method. The field-effect transistor includes: a substrate; a gate dielectric layer located on the substrate, where the gate dielectric layer is a solid oxygen ionic conductor thin film; a channel layer covered on a part of the gate dielectric layer; and a source electrode and a drain electrode respectively located on the gate dielectric layer not covered by the channel layer and on a part of the channel layer.

Abstract: A full-face shaft tunnel boring machine system includes a tunnel boring machine cutterhead device for tunneling downwards in a shaft; a full-hydraulic formwork device for supporting and walling in a wellbore; and an upper muck-discharge system for vertically conveying rock mucks generated by tunneling. The tunnel boring machine cutterhead device comprises a vertical guide frame, a cutter-expanded boring head and an advanced cutterhead that are fixedly connected in a vertical order from top to bottom so as to form an integrated structure. The vertical guide frame is a hollow cylindrical structure and driven to rotate around an axis of the vertical guide frame by a power mechanism, and an outer wall of the vertical guide frame is provided with multiple sets of first guide rollers.

Abstract: A method of improving residual stress in a canister in which fuel assemblies are loaded includes, when the canister having a cylindrical canister shell and a canister lid welded to the upper opening of the canister shell is disposed in a cylindrical cask body, filling the space above and around an upper end portion of the canister in the cask body with fill water. Then, compressive stress is applied to a predetermined region of the upper end portion of the canister in the fill water. This makes it possible to readily apply compressive stress to the canister while shielding radioactive rays by the fill water.

Abstract: A double-layer concentric loading frame structure suitable for a true triaxial testing machine includes an inner-layer frame, an outer-layer frame and a base. A square slot hole is formed in a middle part of the inner-layer frame. The inner-layer frame is mounted on the base through a support platform. Actuators are mounted at a top end and a bottom end of the inner-layer frame. The outer-layer frame sleeves the inner-layer frame concentrically. Four actuators are distributed on an outer periphery of the outer-layer frame. A support plate is mounted at the top end of the inner-layer frame, and two lifting driving cylinders are mounted on the support plate. Piston rods of the lifting driving cylinders extend below the support plate and are connected to an upper surface of the outer-layer frame. A guide post is mounted on the upper surface of the outer-layer frame and extends above the support plate.

Abstract: This disclosure relates to isolated monoclonal antibodies or antigen-binding fragments thereof that specifically bind to PD-1 and block the interaction between PD-1 and PD-L1/PD-L2. The disclosure also relates to antibodies that are chimeric, humanized, bispecific, derivatized, single chain antibodies, portions of fusion proteins or bispecific antibodies. Nucleic acid molecules encoding the antibodies, hybridomas, and methods for expressing antibodies are also provided. Pharmaceutical compositions comprising the antibodies are also provided. This disclosure also provides use of these antibodies to enhance T-cell function and upregulate cell-mediated immune responses for the treatment and prevention of various diseases.

Abstract: A double-layer concentric loading frame structure suitable for a true triaxial testing machine includes an inner-layer frame, an outer-layer frame and a base. A square slot hole is formed in a middle part of the inner-layer frame. The inner-layer frame is mounted on the base through a support platform. Actuators are mounted at a top end and a bottom end of the inner-layer frame. The outer-layer frame sleeves the inner-layer frame concentrically. Four actuators are distributed on an outer periphery of the outer-layer frame. A support plate is mounted at the top end of the inner-layer frame, and two lifting driving cylinders are mounted on the support plate. Piston rods of the lifting driving cylinders extend below the support plate and are connected to an upper surface of the outer-layer frame. A guide post is mounted on the upper surface of the outer-layer frame and extends above the support plate.

Abstract: A sunlight concentrating apparatus includes a plate-like reflecting part, with an upper reflection surface extending in an axial and a width direction, and a lower surface having a central linear region fixed to a main shaft part. A pair of bending mechanisms bend the reflection surface by moving opposite end portions in a central normal direction in accordance with a rotation of the main shaft part. The reflecting part includes a mirror plate and a support plate thereon. In the support plate, the ratio between the distance in the width direction from each end portion in the width direction and the second moment of area at this distance is constant between the end portion and the central linear region, allowing the reflection surface to be bent in an are shape.

Abstract: A pipe with a pipe main body made from fiber reinforced plastic and a connection portion made from resin and having substantially tubular shape, into which an end portion of the pipe main body is inserted, thereby being fixed to the end portion. The connection portion includes an annular cover portion that covers an end face of the pipe main body, and an external tapered male screw portion. When the pipe main body is connected to another pipe main body, the male screw portion is screwed with a substantially tubular tapered female screw portion of a coupling. The pipe has a tubular-shaped front-end protrusion located beyond a front-end portion of the male screw portion. The front-end protrusion includes a region of the pipe main body. The entire circumferential region of the pipe in the vicinity of the front-end portion is reinforced by the front-end protrusion.

Abstract: A pipe includes a tubular reinforced fiber structure, and a tubular matrix resin pipe main body centered on the central axis, together with a reinforced fiber structure, covering an internal side of the reinforced fiber structure on the central axis side, and an external side. An external end surface of the pipe main body has an inclined surface whose diameter is gradually reduced toward the end face, which connects the pipe main body to another pipe main body, with the main body inclined surface coupled to a substantially tubular-shaped coupling. A portion of the reinforced fiber structure near the main body inclined surface has a plurality of fiber bundles extending in parallel to the central axis. This prevents a shear failure of the fiber bundles of the reinforced fiber structure of the main body inclined surface.

Abstract: A pipe includes: a tubular pipe main body made from fiber reinforced plastic; and a substantially tubular connection portion centered on a central axis of the pipe main body, which receives an end portion of the pipe main body, thereby being fixed to the end portion, the connection portion having an external tapered male screw portion. The male screw portion engages a tapered female screw portion on an internal surface of a substantially tubular coupling of another pipe main body. The male screw portion includes, near a screw thread surface, a corresponding metallic mesh layer as a reinforcement layer, other regions of the tapered male screw portion being made from resin, to suppress breakage of the male screw portion.

Abstract: Illustrative embodiments herein disclosed relate to protein arrays, methods for making the arrays and methods for using them, among others. In some embodiments known proteins representing at least 50% of the loci in the human genome are arrayed in known positions on a support. In some embodiments arrays are made of proteins purified from cell lysates by affinity binding to the support. In some embodiments protein arrays are used to decode the binding specificity of antibodies. In some embodiments protein arrays are used to diagnose auto-immune disorders. Many other embodiments and general features are disclosed.