Abstract: Disclosed herein is a composition for enhancing skin elasticity or improving skin wrinkles. In one aspect, 2-isopropylmalic acid or a salt, hydrate or solvate thereof, which is an active ingredient of the present disclosure, activates skin primary cilia and inhibits the expression of MMP-1 to enhance skin elasticity and improve skin wrinkles. In addition, in one aspect, 2-isopropylmalic acid or a salt, hydrate or solvate thereof, which is an active ingredient of the present disclosure, is a safe material and has the advantage that it can be treated in the living body in various forms such as cosmetics and food.

Abstract: The present invention relates to a single nucleotide polymorphism (SNP) for predicting the sensitivity to an anticancer targeted therapeutic formulation, a polynucleotide containing the same, and a method for predicting the sensitivity to an anticancer targeted therapeutic formulation. According to the present invention, it is possible to predict the sensitivity of each individual to a certain anticancer targeted therapeutic formulation, using a small amount of a sample taken from a patient and thus to select a most suitable targeted therapeutic formulation over the entire duration of treatment for the patient.