Abstract: The present disclosure provides compositions and methods of inactivating a lipid enveloped virus in a product feedstream in a manufacturing process of a therapeutic protein using environmentally compatible detergents. The present disclosure provides a detergent mixture comprising two environmentally sustainable detergents: n-Octyl-?-D-Glucopyranoside (OG) and n-Dodecyl-?-D-Maltopyranoside (DDM). The performance of this OG:DDM detergent combination is superior to that of Lauryldimethylamine Oxide (LDAO), ECOSURF™ EH9, or Triton X-100 in the purification of therapeutic proteins such as abatacept and belatacept. OG:DDM combinations are highly effective for viral inactivation, while having essentially no impact on protein stability, protein charge distribution (e.g., sialic acid levels), impurity clearance, protein deamination, or protein oxidation. Accordingly, combinations of OG and DDM can be used as substitutes of Triton X-100 for viral inactivation steps in the production of biologics.

Abstract: A fracturing apparatus includes a motor, a first plunger pump, a power supply platform, a gas turbine engine, a generator, and one or more rectifiers. At least two of the gas turbine engine, the generator, and the one or more rectifiers are arranged on the power supply platform. A first end of the generator is connected to the gas turbine engine. A second end of the generator is connected to the one or more rectifiers. The generator is configured to output a voltage to the one or more rectifiers. The one or more rectifiers are configured to provide power to the motor. The motor is configured to drive the first plunger pump.

Abstract: A function verification method of a liquid leak detection module comprises: installing a liquid leak detection cable to a main board; providing liquid to the liquid leak detection cable and obtaining time parameters including warning generation time; determining whether a sensitivity test is passed; disconnecting the liquid leakage detection cable from the main board, and confirming whether the liquid leakage detection module records an absence warning to determine whether an absence test is passed; after confirming that the liquid leakage detection cable is dry and connected to the main board, disabling and re-enabling a component on the main board, and then confirming whether the liquid leakage detection cable records a liquid leakage warning or an absence warning to determine whether a false-positive test is passed; when the sensitivity test, the absence test and the false-positive test are all passed, the function verification is completed.

Abstract: A driver circuit for a three-dimensional (3D) memory device has a field management structure electrically coupled to a gate conductor. The field management structure causes an electric field peak in a vertical channel of the 3D memory device when a voltage differential exists between the source conductor and the drain conductor and the gate conductor is not biased. The electrical field peak can adjust the electrical response of the driver circuit, enabling the circuit to have a higher breakdown threshold voltage and improved drive current. Thus, the driver circuit can enable a scalable vertical string driver that is above the memory array instead of under the memory array circuitry.

Abstract: Embodiments of the present application provide Ensartinib or a salt thereof and a use of a composition containing Ensartinib or the salt thereof in treatment of a disease carrying MET 14 exon skipping mutation.

Abstract: This disclosure relates to a liquid cooling assembly that includes a base, a cover, a first connector, and a second connector. The cover is disposed on the base. The cover and the base together form an accommodation space therebetween. The cover has an inlet and an outlet respectively located at two opposite sides of the cover in a direction parallel to a longitudinal direction of the cover. The first connector is disposed to the inlet of the cover. The second connector is disposed to the outlet of the cover.

Abstract: A driver circuit for a three-dimensional (3D) memory device has a super junction structure as a field management structure. The super junction structure could be referred to as an extended junction structure, which distributes the electrical field of the junction between the vertical channel and the gate conductor for a string driver. The vertical channel includes a channel conductor to connect vertically between a source conductor and a drain conductor. The extended junction structure extends in parallel with the vertical channel conductor, extending vertically toward the drain conductor, having a height greater than a height of the gate conductor.

Abstract: Provided are an ice maker, a refrigerator and a control method therefor, enabling the efficient separation of ice from ice making grooves in an ice tray at the time point when the ice making is completed, regardless of the size (capacity), operation rate, surrounding temperature and cooling capacity of a refrigerator. To this end, the ice maker, according to the present invention, comprises: an ice tray having ice making grooves formed therein; an ice separating motor driven so that ice is separated from the ice making grooves; a temperature detection unit; and a control unit for controlling the ice separating motor, wherein the control unit operates the ice separating motor or an ice separating heater at an ice separation starting time point or a heating starting time point calculated using temperatures detected according to time by the temperature detection unit, or a cumulative ice making time.

Abstract: Systems, methods, and apparatuses for automatically detecting the risk of dealer default are described. A machine learning model may be trained using a gradient boosting technique on a dataset that includes historical lien information, historical dealer information, and historical vehicle default information. Lien information and financing information for vehicles may be received and correlated. Furthermore, a machine learning model may generate aggregate risk scores for dealers. Furthermore, determination of an aggregate risk score that exceeds a threshold risk score may cause the generation of a notification.

Abstract: In product testing, a script prioritization tool (102) is used to intelligently prioritize the execution sequence of test scripts. This tool creates a repository of test outputs from the executions of test scripts and analyzes the outputs to train and deploy a machine learning, ML, model that defines the priority of the scripts that may need to be executed and the scripts whose execution may be skipped without affecting the quality of testing. Scripts that are more likely to fail and/or are time consuming to execute are prioritized, while other scripts may be skipped. The ML model ranks the scripts based on the average execution time of the script, a count of the execution failures of the script, a count of the number of execution retries for the script, and the most recent failure time of the script. The scripts can be executed based on their rankings for efficiency and time-saving.

Abstract: Proposed are an ice maker and a refrigerator including the ice maker. The ice maker includes a drive motor arranged inside a casing and configured to rotate an ice-making tray or an ejector pin, a gear set operating in unison with the drive motor, an in-unison operating lever provided to operate in unison with the gear set, a magnet being provided on one side of the in-unison operating lever, and a printed circuit board arranged to one side of the in-unison operating lever, a position detection sensor being provided on the printed circuit board in such a manner that an electric contact point is established according to trajectory followed by the moving magnet.

Abstract: A liquid cooling device includes a base plate, a cooling body, and a cover plate. The cooling body includes a frame. A cooling layer is provided in the frame and a reflux layer is provided above the cooling layer. The cooling layer is provided with a plurality of cooling channels extending from a center portion of the cooling body to the frame. The reflux layer is provided with a plurality of reflux channels in communication with the plurality of cooling channels. A periphery of the reflux layer is provided with a drainage flow channel in communication with the plurality of the reflux channels. A center portion of the cover plate being provided with a liquid inlet in communication with the plurality of cooling channels, and the cover plate is further provided with a liquid outlet in communication with the drainage flow channel.

Abstract: The present disclosure provides a liquid cooling system for dissipating heat from a heat source, including a liquid cooling module and a liquid leakage detecting module. The liquid cooling module includes a liquid cooling component. The liquid cooling component includes a liquid cooling plate, a liquid supply pipeline and a liquid return pipeline. The liquid supply pipeline and the liquid return pipeline are in communication with the liquid cooling plate receptively. The liquid leakage detecting module includes a liquid leakage detecting device, a monitoring device and a main wire. The liquid leakage detecting device includes a hub and a plurality of liquid leakage detection branches. The liquid leakage detection branches are electrically connected to the hub in parallel, and are provided in the liquid supply pipeline and the liquid return pipeline respectively. The main wire electrically connects the hub to the monitoring device.

Abstract: The present disclosure provides a cooling device, including a cooling plate and a mounting cover. A lower flow channel is provided in the cooling plate, a top of the cooling plate is provided with a water outlet and two openings. The water outlet is located between the two openings. The mounting cover is sealed on the top of the cooling plate. The mounting cover comprises a first mounting cover and a second mounting cover. The first mounting cover and the cooling plate form an intermediate flow channel, the second mounting cover and the cooling plate form a branch flow channel. The intermediate flow channel is in communication with the two branch flow channels, The first mounting cover is provided with a water inlet, and the two branch flow channels are in communication with the lower flow channel through the two openings.

Abstract: This disclosure relates to a liquid cooling assembly that includes a base, a cover, a first connector, and a second connector. The cover is disposed on the base. The cover and the base together form an accommodation space therebetween. The cover has an inlet and an outlet respectively located at two opposite sides of the cover in a direction parallel to a longitudinal direction of the cover. The first connector is disposed to the inlet of the cover. The second connector is disposed to the outlet of the cover.

Abstract: Systems, methods, and apparatuses for automatically prioritizing unperfected liens are described. A machine learning model may be trained to detect a risk of dealer default. Lien information corresponding to liens for vehicles associated with dealers may be received. Prioritized lien information may be generated based on selection of the liens that satisfy criteria. Financing information for vehicles may be received and correlated with the prioritized lien information. Furthermore, the machine learning model may be used to generate risk scores associated with the liens. The liens may be prioritized based on the aggregate risk scores.

Abstract: Systems, methods, and apparatuses for automatically detecting the risk of dealer default are described. A machine learning model may be trained using a gradient boosting technique on a dataset that includes historical lien information, historical dealer information, and historical vehicle default information. Lien information and financing information for vehicles may be received and correlated. Furthermore, a machine learning model may generate aggregate risk scores for dealers. Furthermore, determination of an aggregate risk score that exceeds a threshold risk score may cause the generation of a notification.

Abstract: Provided are an ice maker, a refrigerator, and a method for controlling the same, which can accurately detect whether ice-making water in accommodated in an ice-making groove is full.

Abstract: In certain examples, methods and semiconductor structures are directed to use of a doped buried region (e.g., Mg-dopant) including a III-Nitride material and having a diffusion path (“ion diffusion path”) that includes hydrogen introduced by using ion implantation via at least one ion species. An ion implantation thermal treatment causes hydrogen to diffuse through the ion implanted path and causes activation of the buried region. In more specific examples in which such semiconductor structures have an ohmic contact region at which a source of a transistor interfaces with the buried region, the ohmic contact region is without etching-based damage due at least in part to the post-ion implantation thermal treatment.

Abstract: In product testing, a script prioritization tool (102) is used to intelligently prioritize the execution sequence of test scripts. This tool creates a repository of test outputs from the executions of test scripts and analyzes the outputs to train and deploy a machine learning, ML, model that defines the priority of the scripts that may need to be executed and the scripts whose execution may be skipped without affecting the quality of testing. Scripts that are more likely to fail and/or are time consuming to execute are prioritized, while other scripts may be skipped. The ML model ranks the scripts based on the average execution time of the script, a count of the execution failures of the script, a count of the number of execution retries for the script, and the most recent failure time of the script. The scripts can be executed based on their rankings for efficiency and time-saving.