Abstract: The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.

Abstract: The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.

Abstract: An earthquake-resistant flat expansion joint using a hinge is provided which includes an expansion joint main body disposed between opposite ends of deck slabs of a bridge or an elevated road, hinged to one side of the deck slab at its one end to enable behavior in X, Y and Z-axis directions, and expanded or shrunk depending on temperature variation and vibrations due to earthquakes to be moved in the X, Y and Z-axis directions, an expansion/shrinkage member connected to one end of the expansion joint main body to accommodate the behavior in X, Y and Z-axis directions due to expansion and shrinkage of the expansion joint main body caused by temperature variation and occurrence of the earthquakes, a hinge shaft support member installed at one end of the deck slab to support a lower part and side parts of a hinge shaft part of the expansion joint main body, an expansion joint support member installed at one end of the other deck slab to support lower parts of an expansion part of the expansion joint main body a

Abstract: A method of installing or exchanging a rubber seal for an expansion joint is provided, which includes installing guide rails for detachably mounting the rubber seal on both vertical parts of lower plates, installing a plurality of guide rollers at both ends of the rubber seal in a longitudinal direction thereof using guide roller fixing members to slidably fix the rubber seal to the guide rails, suspending wires from a lower one side of the expansion joint to an opposite side thereof to a sufficient length to pull the rubber seal, fastening one end of the wire to a wire hole of the guide roller fixing member coupled to the rubber seal from a start point of pushing the rubber seal, inserting a portion of the guide roller fastened to the wire into one start point of the guide rail and pulling the wire from the other termination point of the guide rail, and after inserting the rubber seal, cutting the rubber seal to the length between both ends of the guide rail or the length of the expansion joint and fixing th