Abstract: A spiro-thiophene compound includes a centroid core having a plurality of benzene rings, and a plurality of thiophene molecules covalently bonded to a carbon atom of the plurality of benzene rings of the centroid core to form a centroid-thiophene molecule.

Abstract: A composition having a pi-pi interaction-constructed organic framework (p-OF). The pi-OF includes a plurality of molecular structures, each molecular structure, including: (a) a centroid core having two spirobifluorene (SF) units, the two SF units forming a rigid biplanar conjugated cruciform-shaped spirobifluorene. the two SF units forming an essentially orthogonal configuration; and (b) a plurality of multijoint fragment units, each unit comprising a 3-dicyanomethylidene)indan-1-one (IC) unit, each IC unit is used as an end group (EG) to each end of the two spirobifluorene (SF) units. Each IC unit is configured to interact via a pi-pi interaction with a neighboring IC unit of an adjacent molecular structure or to interact via a CH-interaction with neighboring aromatic group (R1) of an adjacent molecular structure, or both. The composition also includes a bioactive agent absorbed into the pi-OF.

Abstract: A method and apparatus for normalizing data. A computer system receives category data for a first code from a first client of a plurality of clients. The computer system also generates a category rule based on the category data. The computer system also assigns a category to a second code of a second client of the plurality of clients using the category rule. The category data is generated using input from the first client. Assigning the category to the second code of the second client comprises selecting the category rule to use to assign the category to the second code from a plurality of category rules.

Abstract: A method and apparatus for normalizing data. A computer system receives category data for a first code from a first client of a plurality of clients. The computer system also generates a category rule based on the category data. The computer system also assigns a category to a second code of a second client of the plurality of clients using the category rule. The category data is generated using input from the first client. Assigning the category to the second code of the second client comprises selecting the category rule to use to assign the category to the second code from a plurality of category rules.

Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.