Abstract: Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.

Abstract: A display substrate, including: a base substrate; a plurality of data lines on the base substrate; a first insulating layer on a side of the plurality of data lines away from the base substrate; a plurality of gate lines on a side of the first insulating layer away from the plurality of data lines, where extension directions of the gate and data lines are intersected; a second insulating layer on a side of the plurality of gate lines away from the first insulating layer; and a first electrode on a side of the second insulating layer away from the plurality of gate lines, where at least a portion of an orthographic projection of the first electrode on the base substrate is within an region surrounded by orthographic projections of two adjacent data lines on the base substrate and orthographic projections of two adjacent gate lines on the base substrate.

Abstract: Disclosed are a peramivir solution inhalant and a preparation method thereof, the solution inhalant includes: peramivir, an osmotic pressure regulator, a pH regulator, and water, wherein concentration of peramivir is greater than 15 mg/ml; concentration of the osmotic pressure regulator is less than 8 mg/ml; pH value of the solution inhalant ranges from 5.0 to 6.0; the peramivir solution is sterilized in a non-heating manner; the osmotic pressure regulator is selected from sodium chloride or glucose. The solution inhalant has a better stability and a good pulmonary targeting effect, which significantly improves pharmaceutical efficacy and safety.

Abstract: To provide a pneumatic tire excellent in steering stability and fuel efficiency at high-speed driving, it is provided a pneumatic tire having a tread portion with a circumferential groove and a belt layer, wherein a monofilament cord is used as a reinforcing cord for the belt layer; the number of arrangements e (lines/5 cm) of the monofilament cords arranged per 5 cm in the tire width direction in the tire radial cross section of the belt layer is 50/5 cm or more; and the distance G (mm) from the surface of the land portion closest to the equatorial plane among land portions separated by the circumferential groove to the monofilament cord, and the loss tangent (30° C. tan ?) when the rubber composition constituting the surface of the tread portion is measured under conditions of temperature: 30° C., initial strain: 5%, dynamic strain: ±1%, frequency: 10 Hz, and deformation mode: tensile, satisfy 30° C. tan ?×G<1.5.

Abstract: To provide pneumatic tires with excellent ride quality during high-speed driving, a pneumatic tire having a tread portion with a circumferential groove and a belt layer, wherein a monofilament cord is used as a reinforcing cord for the belt layer; and the number of arrangements e (lines/5 cm) of the monofilament cords per 5 cm in the tire width direction in the tire radial cross section of the belt layer, the distance G (mm) from the surface of the land portion closest to the equatorial plane among land portions separated by the circumferential groove to the monofilament cord, and the loss tangent (30° C. tan ?) when the rubber composition constituting the surface of the tread portion is measured satisfy (30° C. tan ?×G)/e>0.015 is provided.

Abstract: A belt layer includes at least one belt ply. The belt ply includes a single-wire cord having a short diameter SD and a long diameter LD, with a ratio SD/LD between the short diameter SD and the long diameter LD being less than 1.00, and a topping rubber covering the single-wire cord. The single-wire cord is arranged so that a direction of the short diameter SD is oriented to a thickness direction of the belt ply. The topping rubber has a complex elastic modulus (E*) of less than 7 MPa under conditions of temperature of 70 degrees Celsius, initial strain of 10%, an amplitude of dynamic strain of ±1.0%, and a frequency of 10 Hz.

Abstract: A belt layer includes at least one belt ply. The belt ply has a single-wire cord having a short diameter SD and a long diameter LD with a ratio SD/LD between the short diameter SD and the long diameter LD being less than 1.00, and a topping rubber covering the single-wire cord. The single-wire cord is disposed so that a direction of the short diameter SD is oriented to a thickness direction of the belt ply. The topping rubber has a complex elastic modulus (E*) of from 7 MPa to 20 MPa under a condition of temperature of 70° C., initial strain of 10%, an amplitude of dynamic strain of ±1.0%, and a frequency of 10 Hz.

Abstract: A large-width cathode roller for producing high-strength ultra-thin copper foil includes titanium side plates and a titanium cylinder sealed by the titanium side plates, and a cathode roller core penetrated through the titanium side plates. Steel-copper explosive clad cylinders and a steel support plate are disposed in/on the side plate, inner ring surfaces of the side plates and the copper plates are connected to a copper sleeve around the cathode roller core, outer ring surfaces of the copper plates and the steel support plates are connected to a copper cylinder, inner ring surfaces of the steel support plates are connected to the cathode roller core; and multiple electrically conductive support rings on the copper cylinder are connected to the copper plates on two sides through the electrically conductive copper bars to form a conducting loop to improve the distribution uniformity of the current on the surface of the cathode roller.

Abstract: A hot-spinning formation method for large-diameter titanium alloy cylindrical parts. A workblank is placed in a resistance furnace to heated to 600-650° C., is maintained at this temperature for 0.5-1 h and is then taken out of the resistance furnace; after the workblank is heated, the inner diameter of the workblank becomes larger; the heated workblank is installed on a mandrel, and spinning is started when a maximum clearance between the workblank and the mandrel is less than 0.5 mm; the mandrel and the spinning rollers do not need to be preheated, and a multi-pass spinning process is adopted, such that the workblank can deform more uniformly. A vertical spinning lathe is used for spinning, the mandrel is easy to change, and the workblank is easy to assemble and disassemble.

Abstract: To provide a pneumatic tire excellent in steering stability and durability at high-speed driving, it is provided a pneumatic tire having a tread portion and a belt layer, wherein the tread portion is arranged on the outer side of the belt layer in the tire radial direction, the reinforcing cord in the belt layer is composed of cords made of monofilaments in which 50/5 cm or more of the monofilaments are arranged in the tire width direction in the tire radial cross section of the belt layer, and the maximum load capacity of the tire WL (kg) and the weight of the tire WT (kg) satisfy (WT/WL)?0.0140.

Abstract: To provide a pneumatic tire in which both low rolling resistance and improvement of noise performance at high-speed driving are sufficiently achieved, it is provided a pneumatic tire having a tread portion and a belt layer, wherein the tread portion is arranged on the outer side of the belt layer in the tire radial direction, the reinforcing cord in the belt layer is composed of cords made of monofilaments in which 50 lines/5 cm or more of the monofilaments are arranged in the tire width direction in the tire radial cross section of the belt layer, and the maximum load capacity of the tire WL (kg) and the weight of the tire WT (kg) satisfy 0.0145?(WT/WL).

Abstract: A large-width cathode roller for producing high-strength ultra-thin copper foil includes titanium side plates and a titanium cylinder sealed by the titanium side plates, and a cathode roller core penetrated through the titanium side plates. Steel-copper explosive clad cylinders and a steel support plate are disposed in/on the side plate, inner ring surfaces of the side plates and the copper plates are connected to a copper sleeve around the cathode roller core, outer ring surfaces of the copper plates and the steel support plates are connected to a copper cylinder, inner ring surfaces of the steel support plates are connected to the cathode roller core; and multiple electrically conductive support rings on the copper cylinder are connected to the copper plates on two sides through the electrically conductive copper bars to form a conducting loop to improve the distribution uniformity of the current on the surface of the cathode roller.

Abstract: A hot-spinning formation method for large-diameter titanium alloy cylindrical parts. A workblank is placed in a resistance furnace to heated to 600-650° C., is maintained at this temperature for 0.5-1 h and is then taken out of the resistance furnace; after the workblank is heated, the inner diameter of the workblank becomes larger; the heated workblank is installed on a mandrel, and spinning is started when a maximum clearance between the workblank and the mandrel is less than 0.5 mm; the mandrel and the spinning rollers do not need to be preheated, and a multi-pass spinning process is adopted, such that the workblank can deform more uniformly. A vertical spinning lathe is used for spinning, the mandrel is easy to change, and the workblank is easy to assemble and disassemble.

Abstract: A tire includes a belt layer in a tread portion. The belt layer includes at least one belt ply. The belt ply includes a plurality of belt cords including a steel single wire having a flat cross-sectional shape. In at least one of the belt cords, the steel single wire has a short diameter direction inclined at an angle ? of less than 90 degrees with respect to a thickness direction of the belt ply.

Abstract: Disclosed is a peramivir dry powder inhaler, comprising a peramivir API or its acceptable salt or hydrate, wherein a single-dose preparation has a content of 5˜30 mg; the particle size distribution D10 of the dry powder is 1.3˜2.2 ?m, D50 is 3˜6 ?m, and D90 is 6˜13 ?m. The peramivir dry powder inhaler prepared can effectively lower the titer of the influenza A virus in mouse lungs, has a notable anti-virus effect, can significantly prolong survival time and reduce mortality rate. The drug efficacy of the peramivir dry powder inhaler is superior to those of the peramivir sodium chloride injection and oseltamivir phosphate. The peramivir dry powder inhaler has a specific lung targeting effect, with notable improvement in drug effectiveness and safety.

Abstract: To provide a pneumatic tire in which both low rolling resistance and improvement of noise performance at high-speed driving are sufficiently achieved, it is provided a pneumatic tire having a tread portion and a belt layer, wherein the tread portion is arranged on the outer side of the belt layer in the tire radial direction, the reinforcing cord in the belt layer is composed of cords made of monofilaments in which 50 lines/5 cm or more of the monofilaments are arranged in the tire width direction in the tire radial cross section of the belt layer, and the maximum load capacity of the tire WL (kg) and the weight of the tire WT (kg) satisfy 0.0145?(WT/WL).

Abstract: To provide pneumatic tires with excellent ride quality during high-speed driving, a pneumatic tire having a tread portion with a circumferential groove and a belt layer, wherein a monofilament cord is used as a reinforcing cord for the belt layer; and the number of arrangements e (lines/5 cm) of the monofilament cords per 5 cm in the tire width direction in the tire radial cross section of the belt layer, the distance G (mm) from the surface of the land portion closest to the equatorial plane among land portions separated by the circumferential groove to the monofilament cord, and the loss tangent (30° C. tan ?) when the rubber composition constituting the surface of the tread portion is measured satisfy (30° C. tan ?×G)/e>0.015 is provided.

Abstract: To provide a pneumatic tire excellent in steering stability and durability at high-speed driving, it is provided a pneumatic tire having a tread portion and a belt layer, wherein the tread portion is arranged on the outer side of the belt layer in the tire radial direction, the reinforcing cord in the belt layer is composed of cords made of monofilaments in which 50/5 cm or more of the monofilaments are arranged in the tire width direction in the tire radial cross section of the belt layer, and the maximum load capacity of the tire WL (kg) and the weight of the tire WT (kg) satisfy (WT/WL)?0.0140.

Abstract: To provide a pneumatic tire excellent in steering stability and fuel efficiency at high-speed driving, it is provided a pneumatic tire having a tread portion with a circumferential groove and a belt layer, wherein a monofilament cord is used as a reinforcing cord for the belt layer; the number of arrangements e (lines/5 cm) of the monofilament cords arranged per 5 cm in the tire width direction in the tire radial cross section of the belt layer is 50/5 cm or more; and the distance G (mm) from the surface of the land portion closest to the equatorial plane among land portions separated by the circumferential groove to the monofilament cord, and the loss tangent (30° C. tan ?) when the rubber composition constituting the surface of the tread portion is measured under conditions of temperature: 30° C., initial strain: 5%, dynamic strain: ±1%, frequency: 10 Hz, and deformation mode: tensile, satisfy 30° C. tan ?×G<1.5.

Abstract: Disclosed are a peramivir solution inhalant and a preparation method thereof, the solution inhalant includes: peramivir, an osmotic pressure regulator, a pH regulator, and water, wherein concentration of peramivir is greater than 15 mg/ml; concentration of the osmotic pressure regulator is less than 8 mg/ml; pH value of the solution inhalant ranges from 5.0 to 6.0; the peramivir solution is sterilized in a non-heating manner; the osmotic pressure regulator is selected from sodium chloride or glucose. The solution inhalant has a better stability and a good pulmonary targeting effect, which significantly improves pharmaceutical efficacy and safety.