Patents by Inventor Dong-Ming Shen

Dong-Ming Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Opthalmic compositions for treating ocular hypertension
    Publication number: 20060148805
    Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
    Type: Application
    Filed: June 25, 2004
    Publication date: July 6, 2006
    Inventors: Meng Hsin Chen, James Doherty, Luping Liu, Swaminathan Natarajan, Dong-Ming Shen, Min Shu
  • Spirocyclic ureas, compositions containing such compounds and methods of use
    Publication number: 20060116366
    Abstract: The present invention relates to spirocyclic ureas, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 1, 2006
    Inventors: Emma Parmee, Fengqi Zhang, Dong-Ming Shen, John Stelmach
  • Substituted pyrazoles, compositions containing such compounds and methods of use
    Publication number: 20060084681
    Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Application
    Filed: January 23, 2004
    Publication date: April 20, 2006
    Inventors: Emma Parmee, Subharekha Raghavan, Teresa Beeson, Dong-Ming Shen
  • Ophthalmic compositions for treating ocular hypertension
    Publication number: 20060020000
    Abstract: This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
    Type: Application
    Filed: November 4, 2003
    Publication date: January 26, 2006
    Inventors: James Doherty, Meng-Hsin Chen, Luping Liu, Swaminathan Natarajan, Dong Ming Shen, Robert Tynebor
  • Ophthalmic compositions for treating ocular hypertension
    Publication number: 20050256117
    Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
    Type: Application
    Filed: June 11, 2003
    Publication date: November 17, 2005
    Inventors: Meng Hsin Chen, Luping Liu, Peter Meinke, Ravi Natarajan, William Parsons, Dong-Ming Shen, Min Shu, John Stelmach, Harold Wood, Fengqi Zhang, David Wisnoski, James Doherty
  • Pyrrolidine modulators of ccr5 chemokine receptor activity
    Publication number: 20040087552
    Abstract: Pyrrolidine compounds of Formula (I), (wherein R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Application
    Filed: July 17, 2003
    Publication date: May 6, 2004
    Inventors: Jeffrey J Hale, Charles G. Caldwell, Dooseop Kim, Dong-Ming Shen, Sander G. Mills, Kevin T. Chapman, Liya Chen, Malcolm MacCoss, Amy Gentry, Christopher L. Lynch, Christopher A. Willoughby, Yuan Cheng
  • N-cyclopentyl modulators of chemokine receptor activity
    Patent number: 6593346
    Abstract: The present invention is directed to compounds of the formula I: (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: July 15, 2003
    Assignee: Merck & Co. Inc.
    Inventors: Paul E. Finke, Kerry A. Hilfiker, Malcolm MacCoss, Kevin T. Chapman, Jennifer L. Loebach, Sander G. Mills, Ravi N. Guthikonda, Shrenik K. Shah, Dooseop Kim, Dong-Ming Shen, Bryan Oates
  • Pyrrolidine modulators of CCR5 chemokine receptor activity
    Patent number: 6531484
    Abstract: Pyrrolidine compounds of Formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8a, R8b, j, k, 1, m, and n are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: March 11, 2003
    Assignee: Merck & co., Inc.
    Inventors: Christopher A. Willoughby, Keith Rosauer, Kevin T. Chapman, Sander G. Mills, Dong-Ming Shen, Min Shu
  • Pyrrolidine modulators of CCR5 chemokine receptor activity
    Publication number: 20020198178
    Abstract: Pyrrolidine compounds of Formula I: 1
    Type: Application
    Filed: October 10, 2001
    Publication date: December 26, 2002
    Inventors: Christopher A. Willoughby, Keith Rosauer, Kevin T. Chapman, Sander G. Mills, Dong-Ming Shen, Min Shu
  • N-cyclopentyl modulators of chemokine receptor activity
    Publication number: 20020120146
    Abstract: The present invention is directed to compounds of the formula I: 1
    Type: Application
    Filed: February 14, 2002
    Publication date: August 29, 2002
    Inventors: Paul E. Finke, Kerry A. Hilfiker, Malcolm MacCoss, Kevin T. Chapman, Jennifer L. Loebach, Sander G. Mills, Ravi N. Guthikonda, Shrenik K. Shah, Dooseop Kim, Dong-Ming Shen, Bryan Oates
  • Cyclopentyl modulators of chemokine receptor activity
    Patent number: 6432981
    Abstract: The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: August 13, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Paul E. Finke, Kerry A. Hilfiker, Jennifer L. Loebach, Malcolm Maccoss, Sander G. Mills, Dong-Ming Shen, Bryan Oates
  • Pyrrolidine modulators of CCR5 chemokine receptor activity
    Publication number: 20020094989
    Abstract: Pyrrolidine compounds of Formula I: 1
    Type: Application
    Filed: October 10, 2001
    Publication date: July 18, 2002
    Inventors: Jeffrey J. Hale, Christopher L. Lynch, Charles G. Caldwell, Christopher A. Willoughby, Dooseop Kim, Dong-Ming Shen, Sander G. Mills, Kevin T. Chapman, Liya Chen, Amy Gentry, Malcolm MacCoss, Zenon D. Konteatis
  • N-cyclopentyl modulators of chemokine receptor activity
    Patent number: 6358979
    Abstract: The present invention is directed to compounds of the formula I: (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: March 19, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Paul E. Finke, Kerry A. Hilfiker, Malcolm MacCoss, Kevin T. Chapman, Jennifer L. Loebach, Sander G. Mills, Ravi N. Guthikonda, Shrenik K. Shah, Dooseop Kim, Dong-Ming Shen, Bryan Oates
  • Pyrrolidine modulators of chemokine receptor activity
    Patent number: 6248755
    Abstract: The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R14 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: June 19, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Kevin Chapman, Jeffrey Hale, Dooseop Kim, Christopher Lynch, Shrenik Shah, Kothandaraman Shankaran, Dong-Ming Shen, Christopher Willoughby, Malcolm MacCoss, Sander G. Mills, Jennifer L. Loebach, Ravindra N. Guthikonda
  • Diamondoid derivatives for pharmaceutical use
    Patent number: 5576355
    Abstract: A method of inhibiting viruses in which a virus is contacted with diamondoid alcohol, ketone, ketone derivative, adamantyl amino acid, quaternary salt or combinations thereof which have antiviral properties. These diamondoid derivatives are shown to have antiviral activity against HIV.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: November 19, 1996
    Assignee: Mobil Oil Corp.
    Inventors: Catherine S. H. Chen, Dong-ming Shen
  • Fiber optic cable and viscous filler material
    Patent number: 5510549
    Abstract: The invention provides a fiber optic cable and a diamondoid-based viscous filling material for a fiber optic cable.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: April 23, 1996
    Assignee: Mobil Oil Corporation
    Inventors: Henry Ashjian, Dong-Ming Shen, Margaret M. Wu
  • Synthesis of 4-hydroxy-2-adamantanes and related compounds
    Patent number: 5430193
    Abstract: The invention provides a method for converting a lactone of a diamondoid compound to the hydroxyketone of the diamondoid compound wherein the hydroxyl group and the carbonyl group are separated by at least one bridgehead carbon comprising reacting an anhydride containing from about 2 to about 20 carbon atoms with the lactone of the diamondoid compound in the presence of acid.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: July 4, 1995
    Assignee: Mobil Oil Corporation
    Inventor: Dong-Ming Shen
  • Synthesis of adamantane-2,4-dione
    Patent number: 5410092
    Abstract: The invention provides a method for converting a lactone of a diamondoid compound to the hydroxyketone of the diamondoid compound wherein the hydroxyl group and the carbonyl group are separated by at least one bridgehead carbon comprising reacting an anhydride containing from about 2 to about 20 carbon atoms with the lactone of the diamondoid compound in the presence of acid.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: April 25, 1995
    Assignee: Mobil Oil Corporation
    Inventor: Dong-Ming Shen
  • Fiber optic cable and viscous filler material
    Patent number: 5400427
    Abstract: The invention provides a fiber optic cable and a diamondoid-based viscous filling material for a fiber optic cable.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: March 21, 1995
    Assignee: Mobil Oil Corporation
    Inventors: Henry Ashjian, Dong-Ming Shen, Margaret M. Wu
  • Nitrogenous 1,3-substituted adamantanes
    Patent number: 5382684
    Abstract: The invention is directed to nitrogenous 1,3-substituted adamantanes, their preparation and use in synthesis of inorganic porous solids. The nitrogenous 1,3-substituted adamantanes are compounds having the formula: ##STR1## wherein R is a nitrogenous moiety selected from the group consisting of --(CH.sub.2).sub.n-1 CONR'.sub.2, --(CH.sub.2).sub.n NR'.sub.2 and --(CH.sub.2).sub.n NR'.sub.3.sup.+ A.sup.-, wherein R' is lower alkyl of 1 to 5 carbon atoms, n=1 to 5, R.sup.1 and R.sup.2 are selected from H and alkyl groups of 1 to 3 carbon atoms, and A.sup.- is an anion.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: January 17, 1995
    Assignee: Mobil Oil Corporation
    Inventors: Ahmad Moini, Dong-Ming Shen