Patents by Inventor Dong Ming

Dong Ming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor XIa inhibitors
    Patent number: 10143681
    Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: December 4, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Dong-Ming Shen, Rongze Kuang, Puneet Kumar, Joseph L. Duffy, Cheng Zhu, Amjad Ali, Meng Yang, John S. Debenham
  • FACTOR XIA INHIBITORS
    Publication number: 20180339977
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
    Type: Application
    Filed: October 24, 2016
    Publication date: November 29, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Jiayi Xu, Amjad Ali, Wei Zhou, Ying-Duo Gao, Scott D. Edmondson, Eric Mertz, Santhosh F. Neelamkavil, Weiguo Liu, Wanying Sun, Dong-Ming Shen, Bart Harper, Cheng Zhu, Thomas Bara, Yeon-Hee Lim, Meng Yang
  • Heteroaryl-Pyrimidinone Compounds as PDE2 Inhibitors
    Publication number: 20180280390
    Abstract: The present invention is directed to substituted pyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: May 2, 2016
    Publication date: October 4, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dong-Ming Shen, Jonathan E. Wilson, Troy McCracken
  • PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20180256575
    Abstract: The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: May 10, 2016
    Publication date: September 13, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dong-Ming Shen, Deping Wang, XiaoXia Qian, Bart Harper, Meng Yang, Yingjian Bo
  • TRIAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20180237422
    Abstract: The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: March 11, 2016
    Publication date: August 23, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dong-Ming Shen, Christopher J. Sinz, Alejandro Crespo, Johnathan E. Wilson, Troy McCraken, Shimin XU, Haitang Li
  • DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20180148453
    Abstract: The present invention is directed to dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: May 31, 2016
    Publication date: May 31, 2018
    Applicants: Merck Sharp & Dohme Corp., MSD R & D (China) Co. LTD.
    Inventors: Dong-Ming Shen, Michael P. Dwyer, Christopher J. Sinz, Deping Wang, Shawn J. Stachel, Daniel V. Paone, Ashley Forster, Richard Berger, Yili Chen, Yimin Qian, Shimin Xu, Chunmei Hu
  • 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20180134712
    Abstract: The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypo-function or basal ganglia dysfunction.
    Type: Application
    Filed: May 24, 2016
    Publication date: May 17, 2018
    Applicants: Merck Sharp & Dohme Corp., MSD R & D (China) Co. LTD.
    Inventors: Dong-Ming Shen, Michael P. Dwyer, Christopher J. Sinz, Deping Wang, Shawn J. Stachel, Daniel V. Paone, Ashley Forster, Richard Berger, Yilli Chen, Yimin Qian, Shimin Xu, Chunmel Hu, William D. Shipe, Jianmin Fu, Zhigang Guo, HAITANG LI, Yingjian Bo
  • PYRAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20180057480
    Abstract: The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
    Type: Application
    Filed: March 21, 2016
    Publication date: March 1, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dong-Ming Shen, Jonathan E. Wilson, Meng Yang, Dann Parker, Zack Zhiqiang Guo, Alejandro Crespo, Deping Wang, Troy McCracken
  • FACTOR XIa INHIBITORS
    Publication number: 20180050022
    Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Application
    Filed: August 21, 2017
    Publication date: February 22, 2018
    Applicant: MERCK SHARP & DOHME CORP
    Inventors: Dong-Ming Shen, Rongze Kuang, Puneet Kumar, Joseph L. Duffy, Cheng Zhu, Amjad Ali, Meng Yang, John S. Debenham
  • Waterproof presskey structure and waterproof mobile phone utilizing same
    Patent number: 9866659
    Abstract: A waterproof presskey structure includes a shell, a button or presskey, and an elastic element. The elastic element and the shell can be assembled together with gum, the presskey is movably assembled to the shell and matches with the elastic element. The elastic element comprises a tubular structure having an elastic wall. The elastic wall is arched, and the elastic wall projects out towards within the tubular structure. For the arched elastic wall stretches under pressure from the button or presskey, an assembly of the elastic element and other parts is not affected, the elastic element cannot be separated from the shell due to the gum failing, and water resistance between the presskey and the shell is increased.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: January 9, 2018
    Assignee: Power Idea Technology (Shenzhen) Co., Ltd.
    Inventors: Ji-Dong Ma, Dong-Ming Chen
  • Piperazine derivatives as HIV protease inhibitors
    Patent number: 9840478
    Abstract: The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: December 12, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Peter D. Williams, John A. McCauley, David Jonathan Bennett, Christopher J. Bungard, Lehua Chang, Michael P. Dwyer, M. Katharine Holloway, Kartik M. Keertikar, H. Marie Loughran, Jessie J. Manikowski, Gregori J. Morriello, Dong-Ming Shen, Edward C. Sherer, Jurgen Schultz, Sherman T. Waddell, Catherine M. Wiscount, Nicolas Zorn, Xin-Jie Chu, Satyanarayana Tummanapalli, Vijayasaradhi Sivalenka, Bin Hu, Tao Ji, Bin Zhong
  • Pyrimidone carboxamide compounds as PDE2 inhibitors
    Patent number: 9815796
    Abstract: Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: November 14, 2017
    Assignees: Merck Sharp & Dohme Corp., MSD R & D (China) Co. LTD.
    Inventors: Dong Ming Shen, Melissa Egbertson, Richard Berger, XiaoXia Qian, Yimin Qian, Bart Harper, Meng Yang, Zack Zhiqiang Guo, Vanessa L. Rada, Deping Wang, Timothy A. Cernak, Christopher Sinz, Ming Wang, Jonathan E. Wilson, Shimin Xu
  • Waterproof structure for button of electronic product and waterproof mobile phone using the same
    Patent number: 9818556
    Abstract: A waterproof structure for a button includes a casing, a button, and an elastic member. The elastic member is arranged on the casing and is contacted by the elastic member. The elastic member is integrated with the casing. The elastic member includes a tubular structure arranging an arc-shaped structure protruding towards interior of the tubular structure. The elastic wall allows a range of elastic travel to activate the switch under the button. The elastic member is a built-in component.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: November 14, 2017
    Assignee: Power Idea Technology (Shenzhen) Co., Ltd.
    Inventors: Fan-Guo Chen, Dong-Ming Chen
  • Tri-proof structure and mobile phone using the same
    Patent number: 9794383
    Abstract: A mobile phone proofed against water, dust, and physical shocks (tri-proofed) has a structure comprising a first casing, a second casing, and a third casing. The first casing is provided with protrusions, and the third casing is provided with convex blocks. The second casing is provided with a first groove for a protrusion, and is provided with a second groove for a convex block. The protrusions and the convex blocks are both interference fits in the grooves. Moreover, the second casing also includes cosmetic surfaces. The first casing and the third casing have outer surfaces and each cosmetic surface protrudes out of the outer surfaces. The cosmetic surfaces are in first contact when the mobile phone is dropped. Waterproofing, dustproofing, and shockproofing are simultaneously achieved with the single second casing structure.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: October 17, 2017
    Assignee: Power Idea Technology (Shenzhen) Co., Ltd.
    Inventors: Ji-Dong Ma, Dong-Ming Chen
  • WATERPROOF STRUCTURE FOR BUTTON OF ELECTRONIC PRODUCT AND WATERPROOF MOBILE PHONE USING THE SAME
    Publication number: 20170154741
    Abstract: A waterproof structure for a button includes a casing, a button, and an elastic member. The elastic member is arranged on the casing and is contacted by the elastic member. The elastic member is integrated with the casing. The elastic member includes a tubular structure arranging an arc-shaped structure protruding towards interior of the tubular structure. The elastic wall allows a range of elastic travel to activate the switch under the button. The elastic member is a built-in component.
    Type: Application
    Filed: December 13, 2016
    Publication date: June 1, 2017
    Inventors: FAN-GUO CHEN, DONG-MING CHEN
  • WATERPROOF PRESSKEY STRUCTURE AND WATERPROOF MOBILE PHONE UTILIZING SAME
    Publication number: 20170064053
    Abstract: A waterproof presskey structure includes a shell, a button or presskey, and an elastic element. The elastic element and the shell can be assembled together with gum, the presskey is movably assembled to the shell and matches with the elastic element. The elastic element comprises a tubular structure having an elastic wall. The elastic wall is arched, and the elastic wall projects out towards within the tubular structure. For the arched elastic wall stretches under pressure from the button or presskey, an assembly of the elastic element and other parts is not affected, the elastic element cannot be separated from the shell due to the gum failing, and water resistance between the presskey and the shell is increased.
    Type: Application
    Filed: November 10, 2016
    Publication date: March 2, 2017
    Inventors: JI-DONG MA, DONG-MING CHEN
  • PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS
    Publication number: 20170015633
    Abstract: Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: December 17, 2014
    Publication date: January 19, 2017
    Applicants: Merck Sharp & Dohme Corp., MSD R & D (China) Co. LTD.
    Inventors: Dong Ming Shen, Melissa Egbertson, Richard Berger, XiaoXia Qian, Yimin Qian, Bart Harper, Meng Yang, Zack Zhi Qiang Guo, Vanessa L. Rada, Deping Wang, Timothy A. Cernak, Christopher Sinz, Ming Wang, Jonathan E. Wilson, Shimin Xu
  • TRI-PROOF STRUCTURE AND MOBILE PHONE USING THE SAME
    Publication number: 20160381193
    Abstract: A mobile phone proofed against water, dust, and physical shocks (tri-proofed) has a structure comprising a first casing, a second casing, and a third casing. The first casing is provided with protrusions, and the third casing is provided with convex blocks. The second casing is provided with a first groove for a protrusion, and is provided with a second groove for a convex block. The protrusions and the convex blocks are both interference fits in the grooves. Moreover, the second casing also includes cosmetic surfaces. The first casing and the third casing have outer surfaces and each cosmetic surface protrudes out of the outer surfaces. The cosmetic surfaces are in first contact when the mobile phone is dropped. Waterproofing, dustproofing, and shockproofing are simultaneously achieved with the single second casing structure.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Inventors: JI-DONG MA, DONG-MING CHEN
  • Smartphone
    Patent number: D775596
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: January 3, 2017
    Assignee: Power Idea Technology (Shenzhen) Co., Ltd.
    Inventors: Zhen-Yu Guo, Dong-Ming Chen
  • Feature phone
    Patent number: D778861
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: February 14, 2017
    Assignee: Power Idea Technology (Shenzhen) Co., Ltd.
    Inventors: Zhen-Yu Guo, Dong-Ming Chen