Patents by Inventor Dong-Myung Kim

Dong-Myung Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7041479
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: May 9, 2006
    Assignee: The Board of Trustess of the Leland Stanford Junior University
    Inventors: James Robert Swartz, Dong-Myung Kim
  • Patent number: 6994986
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides. In order to improve the performance of in vitro protein synthesis reactions, metabolic inhibitors, or manipulation of a source organism, is used to diminish or avoid the action of enzymes responsible for undesirable amino acids production or depletion. A homeostatic system may be used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: February 7, 2006
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: James Robert Swartz, Dong-Myung Kim
  • Publication number: 20040038332
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.
    Type: Application
    Filed: March 31, 2003
    Publication date: February 26, 2004
    Inventors: James Robert Swartz, Dong-Myung Kim
  • Patent number: 6683095
    Abstract: A novel 3-hydroxychromen-4-one derivative, pharmaceutically acceptable salt, hydrate, solvate or isomer thereof which is useful as an inhibitor for Cyclin Dependent Kinase (“CDK”) is disclosed. Further, a process for preparing the compound and a composition for suppression or treatment of cancer and diseases induced by cell proliferation such as inflammation, angiostenosis, angiogenesis, etc. is disclosed comprising the compound as an active component together with pharmaceutically acceptable carriers.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: January 27, 2004
    Assignee: LG Life Sciences Ltd.
    Inventors: Chang-Yong Hong, Jin-Ho Lee, Tae-Sik Park, Jong-Hyun Kim, Sei-Hyun Choi, Sook-Kyung Yoon, Hyun-Ho Chung, Ho-Sun Son, Eunice Eun-Kyeong Kim, Seong-Gu Ro, Shin-Wu Jeong, Dong-Myung Kim
  • Publication number: 20030125356
    Abstract: The present invention relates to a novel 3-hydroxychromen-4-one derivative of formula (1), pharmaceutically acceptable salt, hydrate, solvate or isomer thereof which is useful as an inhibitor for Cyclin Dependent Kinase (“CDK”); to a process for preparing the compound of formula (1); and to a composition for suppression or treatment of cancer and diseases induced by cell proliferation such as inflammation, angiostenosis, angiogenesis, etc. comprising the compound of formula (1) as an active component together with pharmaceutically acceptable carriers.
    Type: Application
    Filed: November 1, 2002
    Publication date: July 3, 2003
    Inventors: Chang-Yong Hong, Jin-Ho Lee, Tae-Sik Park, Jong-Hyun Kim, Sei-Hyun Choi, Sook-Kyung Yoon, Hyun-Ho Chung, Ho-Sun Son, Eunie Eun-Kyeong Kim, Seong-Gu Ro, Shin-Wu Jeong, Dong-Myung Kim
  • Patent number: 6548276
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: April 15, 2003
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: James Robert Swartz, Dong-Myung Kim
  • Patent number: 6500846
    Abstract: The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase (CDK), a process for preparation thereof, and a composition of anti-cancer agent or agent for treating neurodegenerative disease comprising this compound as an active ingredient.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: December 31, 2002
    Assignee: LG Chemical, Ltd.
    Inventors: Chang Yong Hong, Tae Sik Park, Young Kwan Kim, Jin Ho Lee, Jong Hyun Kim, Dong Myung Kim, Ho Sun Son, Sang Woong Kim, Eunice Eun Kyeong Kim
  • Patent number: 6491867
    Abstract: A hydrogen storage alloy, represented by the following formula I which is suitable for use as an active anode material for ni-metal hydride secondary cells by virtue of its high discharge characteristics including, for example, a discharge capacity ranging from approximately 300 to 400 mAh/g and a rate capability of at least 80%; Zr1−xtix(MnuVvNiy)z  I wherein, x, u, v, and z each represent an atom fraction under the condition of: 0<x≦0.2, 1.5≦u≦0.7, 0.5≦v≦0.7, 1.0≦y≦1.4, and 0.84≦z≦1.0.1.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: December 10, 2002
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai Young Lee, Dong Myung Kim, Jae Han Jung, Ji Sang Yu, Sang Min Lee, Jeong Gun Park, Ho Lee
  • Publication number: 20020081660
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides. In order to improve the performance of in vitro protein synthesis reactions, metabolic inhibitors, or manipulation of a source organism, is used to diminish or avoid the action of enzymes responsible for undesirable amino acids production or depletion. A homeostatic system may be used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.
    Type: Application
    Filed: September 7, 2001
    Publication date: June 27, 2002
    Inventors: James R. Swartz, Dong-Myung Kim
  • Publication number: 20020058303
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.
    Type: Application
    Filed: September 5, 2001
    Publication date: May 16, 2002
    Inventors: James Robert Swartz, Dong-Myung Kim
  • Patent number: 6372383
    Abstract: Disclosed is a method for preparing a high performance, negative electrode for Ni/metal hydride cells. A Zr-based hydrogen storage alloy, a binder comprising a mixture of polytetrafluoroethylene and 50th and a thickening agent (hydroxypropylmethyl cellulose), and a current collector comprising carbon black and copper are slurried and molded into a paste-type electrode. In a closed type cell, the copper repetitively undergoes melting and deposition on the electrode during charging and discharging cycles, allowing the electrode to show a similar change in surface morphology and electrochemical properties to that of a conventionally electroless plated electrode.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: April 16, 2002
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai Young Lee, Kuk Jin Jang, Dong Myung Kim, Ji Sang Yu, Sang Min Lee, Ho Lee
  • Patent number: 6337191
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of biological molecules where ATP is required for synthesis. Of particular interest is the synthesis of polymers, e.g. nucleic acids, polypeptides, and complex carbohydrates. Glycolytic intermediates or glucose are used as an energy source, in combination with added NADH or NAD+.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: January 8, 2002
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: James Swartz, Dong-Myung Kim
  • Patent number: 6168931
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of biological molecules where ATP is required for synthesis. Of particular interest is the synthesis of polymers, e.g. nucleic acids, polypeptides, and complex carbohydrates. A homeostatic system is used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. Since inorganic phosphate can be an inhibitory by-product of synthesis, the period of time when synthesis is maintained in vitro can be extended. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: January 2, 2001
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: James R. Swartz, Dong-Myung Kim
  • Patent number: 6106768
    Abstract: There are disclosed Mm/Ni type hydrogen storage alloys for Ni/MH secondary cells. The alloys which allow the cells to be of high performance and high capacity can be prepared at lower costs than the production costs of conventional Co-rich hydrogen storage alloys, by reducing the amount of the Co element. The Co element is partially or wholly replaced by by Cr, Cu, Fe, Zn and/or Zi, which are each known to be of stronger affinity for hydrogen than is Co and to have such a strong oxidation tendency in electrolytes as to form a highly dense oxide. The novel alloys have discharge capacities and electrode life span as good as those of the conventional Co-rich hydrogen storage alloys but have advantages over the Co-rich alloys, including performance-to-cost.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: August 22, 2000
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai Young Lee, Kuk Jin Jang, Jae Han Jung, Dong Myung Kim, Ji Sang Yu, Sang Min Lee, Jeong Gun Park, Ho Lee
  • Patent number: 6086820
    Abstract: A method for producing an electrode of Ni/metal hydride alloy secondary cells. The electrode may be produced by mixing an active material with approximately 10-50 wt % of Cu powders, which can serve as a binder as well as a current collector, and cold-pressing the mixture at a pressure of 10 ton/cm. As the Cu-compacted electrode continues to experience the cycle of charge and discharge, the desolution-deposition of Cu is gradually produced. This desolution-deposition of Cu allows Cu to be deposited on the surface of the electrode comprising the hydrogen storage alloy, so that the electrode can be similar to a conventional Cu-electroless plated electrode in surface morphology. Consequently, the method of the invention can be an alternative for conventional electroless plating, which significantly improves the general functions of hydrogen storage alloy electrode, including low temperature dischargeability and high rate capability, without producing pollution of the environment.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: July 11, 2000
    Assignee: Korea Advanced Institute of Science & Technology
    Inventors: Jai Young Lee, Kuk Jin Jang, Jae Han Jung, Dong Myung Kim, Ji Sang Yu, Sang Min Lee, Jeong Gun Park, Ho Lee
  • Patent number: 5922146
    Abstract: The present invention provides a hydrogen-absorbing alloy system of ultra high capacity for electrode of secondary battery. In accordance with the present invention, the hydrogen-absorbing Ti alloy system is represented as a following general formula:Ti.sub.A Zr.sub.B V.sub.C Mn.sub.D Ni.sub.E M.sub.Fwherein, M represents at least one metal which is selected from the group consisting of Cr, Co, Fe, Cu, Al, Si, Hf, Nb, Mo and R.E., where R.E. represents at least one metal which is selected from the group of rare-earth elements consisting of La, Ce, Pr, Nd and Sm; and, A, B, C, D, E and F have atomic ratios ranging 0.2.ltoreq.A.ltoreq.0.35, 0.03.ltoreq.B.ltoreq.0.15, 0.15.ltoreq.C.ltoreq.0.4, 0.8.ltoreq.D.ltoreq.0.2, 0.13.ltoreq.E.ltoreq.0.35 and 0.ltoreq.F.ltoreq.0.1, respectively, with the proviso that A+B+C+D+E+F=1 and A+B.ltoreq.0.45.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: July 13, 1999
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai-Young Lee, Han-Ho Lee, Ki-Young Lee, Jae-Han Jung, Dong-Myung Kim, Ji-Sang Yu
  • Patent number: 5888317
    Abstract: The present invention relates to a material for hydrogen-storage constituted by Ti-Mn alloy system which has a high hydrogen-storage capacity, plateau hydrogen dissociation equilibrium pressure, hypostoichiometric composition and crystal structure of C14. Ti-Mn alloy system for hydrogen-storage of the invention which has a C14 crystal structure, is represented as: Ti.sub.u Zr.sub.v Mn.sub.w Cr.sub.x V.sub.y X.sub.z, wherein, X is at least one of element selected from the group consisting of Fe, Al and Ni; u, v, w, x, y and z are mole numbers of each components; 0.7<u<1.0; 0<v<0.3; 1.0.ltoreq.w.ltoreq.1.3; 0.1.ltoreq.x.ltoreq.0.4; 0<y<0.3; 0.ltoreq.z.ltoreq.0.2; 0.7<u+v<1.0; 1.4.ltoreq.w+x.ltoreq.1.7; and, 1.3.ltoreq.w+x+y+z<2.0.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: March 30, 1999
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai-Young Lee, Ki-Young Lee, Han-Ho Lee, Dong-Myung Kim, Ji-Sang Yu, Jae-Han Jung, Soo-Geun Lee
  • Patent number: 5874824
    Abstract: The present invention provides a method of activation treatment of a Ni/MH secondary battery which comprises a step of immersing an electrode or battery in a solution or electrolyte and charging/discharging concurrently. In accordance with the activation treatment of a Ni/MH secondary battery by hot-charging method of the invention, the time required for activation treatment is remarkably saved and the activation process is carried out in a highly efficient manner, compared to the conventional methods of activation treatment.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: February 23, 1999
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai-Young Lee, Dong-Myung Kim, Ki-Young Lee, Jae-Han Jung, Ji-Sang Yu, Han-Ho Lee
  • Patent number: 5857139
    Abstract: The present invention relates to a process for preparing an electrode for secondary battery employing hydrogen-storage alloy systems, more specifically, to a process for preparing an anode material for secondary battery which can be charged/discharged in an electrolyte and has a high discharge efficiency and energy density per unit weight, by sintering a mixture of hydrogen-storage alloy systems. An electrode for secondary battery of the present invention is prepared by the process which comprises the steps of: (i) mixing a hydrogen-storage alloy powder free of Ni with a hydrogen-storage alloy powder containing Ni over 30 atomic %; (ii) cold-pressing the mixed powder at a pressure of 5 to 15 ton/cm.sup.2 ; (iii) sintering the cold-pressed mixture in a quartz tube at 900.degree. C. for 5 to 15 min under a vacuum condition of 10.sup.-2 to 10.sup.-3 torr; and, (iv) quenching the sintered material.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: January 5, 1999
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai-Young Lee, Ki-Young Lee, Han-Ho Lee, Dong-Myung Kim, Ji-Sang Yu, Jae-Han Jung, Soo-Geun Lee
  • Patent number: 5701078
    Abstract: The present invention relates to a method of measuring residual capacity of a Ni/MH (nickel/metal hydride) cell by measuring the change in the electrical resistivity of a Ni/MH cell according to the change of the concentration of hydrogen in metal hydride. According to the present invention, a method for measuring residual capacity of a Ni/MH cell comprises the steps of measuring electrical resistivity of a first Ni/MH cell, and determining the residual capacity of the first Ni/MH cell (i) from a predetermined data of n-pairs of electrical resistivity values and residual capacity values of a second Ni/MH cell which has substantially the same composition as the composition of the first Ni/MH cell, or (ii) based on a predetermined functional relationship between the electrical resistivity and residual capacity of the second Ni/MH cell.
    Type: Grant
    Filed: July 13, 1995
    Date of Patent: December 23, 1997
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jai-Young Lee, Hwan-Cheol Lee, Jon-Ha Lee, Han-Ho Lee, Dong-Myung Kim