Patents by Inventor Dong S. Yang

Dong S. Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of taxanes
    Patent number: 9926287
    Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: March 27, 2018
    Assignee: Phyton Holdings, LLC
    Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
  • PURIFICATION OF TAXANES
    Publication number: 20170066734
    Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
  • Purification of taxanes
    Patent number: 9527825
    Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: December 27, 2016
    Assignee: Phyton Holdings, LLC
    Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
  • PURIFICATION OF TAXANES
    Publication number: 20160176837
    Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.
    Type: Application
    Filed: February 25, 2016
    Publication date: June 23, 2016
    Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
  • Purification of taxanes
    Patent number: 9303004
    Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: April 5, 2016
    Assignee: Phyton Holdings, LLC
    Inventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
  • PURIFICATION OF TAXANES
    Publication number: 20150005517
    Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.
    Type: Application
    Filed: February 24, 2014
    Publication date: January 1, 2015
    Applicant: Phyton Holdings LLC
    Inventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
  • Purification of taxanes
    Patent number: 8703982
    Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: April 22, 2014
    Assignee: Phyton Holdings LLC
    Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James A. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
  • Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
    Patent number: 7897796
    Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: March 1, 2011
    Assignee: Phyton Holdings, LLC
    Inventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
  • PURIFICATION OF TAXANES
    Publication number: 20100145080
    Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.
    Type: Application
    Filed: February 12, 2010
    Publication date: June 10, 2010
    Applicant: Phyton Holdings LLC
    Inventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
  • Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
    Patent number: 6956123
    Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: October 18, 2005
    Assignee: Natural Pharmaccuticals, Inc.
    Inventors: James H. Johnson, T. G. Sambandan, Barry J. Haad, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, III, Dong S. Yang
  • Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
    Publication number: 20040186305
    Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.
    Type: Application
    Filed: September 18, 2003
    Publication date: September 23, 2004
    Inventors: James H. Johnson, T.G. Sambandan, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Jucham, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, Dong S. Yang