Abstract: A cordycepin-based derived compound with an anti-tumor effect, and a structure of the compound is as shown in formula I; a cordycepin derivative and a pharmaceutical composition thereof provided by the invention have a good anti-tumor proliferation effect; compared with a parent drug, the cordycepin derivative has better affinity to cell membranes, so that a half-life period of in-vivo metabolism of the drug is longer, and in-vivo remaining time of the drug is longer; compared with other nucleoside anti-tumor drugs, the cordycepin derivative and the pharmaceutical composition thereof provided by the invention have wider types and action ranges of tumors, have excellent inhibition effects on a gastric cancer, a pancreatic cancer, a liver cancer, a small cell lung cancer, a colorectal cancer, melanoma, an ovarian cancer and the like, and have lower side effects and better curative effects.

Abstract: The present invention discloses a manual type C-shaped wire clamp operating device, includes an insulating operating rod, wherein an upper end of the insulating operating rod is provided with a threaded rod, and the threaded rod includes an upper thread and a lower thread; a wire clamp clamping device, wherein the wire clamp clamping device includes a first spring, a wire clamp seat and a floating clamping block located above the wire clamp seat, a wire clamp seat threaded hole is formed in the wire clamp seat, the wire clamp seat threaded hole is in fit connection with the lower thread of the threaded rod; a drainage wire pressing device, wherein the drainage wire pressing device includes a guide rod arranged on the wire clamp seat and a drainage wire pressing block sliding along the guide rod, and a pressing block threaded hole is formed in the drainage wire pressing block.

Abstract: An image outputting device includes a sensing circuit for generating an image signal according to a configuration; a processing circuit, coupled to the sensing circuit, for performing an image processing on the image signal according to the configuration to generate an image processing result; and a controlling circuit, coupled to the sensing circuit and the processing circuit, for setting the configuration and entering an operating system after setting the configuration.

Abstract: Disclosed are a super-resolution imaging system (1, 41, 51), a super-resolution imaging method, a biological sample identification system (4, 61) and method, a nucleic acid sequencing imaging system (5) and method, and a nucleic acid identification system (6) and method. The super-resolution imaging system (1, 41, 51) includes an illumination system (A) and an imaging system (B). The illumination system (A) outputs excitation light to irradiate a biological sample to generate excited light, and the imaging system (B) collects and records the excited light to generate an excited light image. The illumination system (A) includes an excitation light source (10, 10a) and a structured light generation and modulation device (11, 11a). The excitation light source (10, 10a) outputs the excitation light, and the structured light generation and modulation device (11, 11a) modulates the excitation light into structured light to irradiate the biological sample to generate the excited light.

Abstract: Halite scales in an oilfield brine that has a potential for halite scaling can have halite scale formation inhibited or prevented by adding an effective amount of an additive, where the additive contains at least one non-water-soluble quaternary ammonium compound and at least one organic solvent. The quaternary ammonium compound may be benzyl-alkyldimethyl ammonium chloride, where the alkyl group has from 2 to 30 carbon atoms. The organic solvent may be one or more alcohol or glycol.

Abstract: Compositions and methods are provided for potent mRNA vaccines for treatment of cancers with a mutation in the ras gene family. The compositions include a pharmaceutical composition comprising, or consisting essentially of, or yet further comprising mRNA molecules encoding at least one of multiple peptides of a group of somatic mutants and a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, or subcutaneous injection of the composition as disclosed herein.

Abstract: The present disclosure provides a grouting reinforcement filler for mining and a preparation method thereof The grouting reinforcement filler for mining includes a first component and a second component. The first component includes 100 to 130 parts by weight of a polyol polymer, 0.8 to 1.2 parts by weight of a catalyst, 0.1 to 0.3 parts by weight of a foaming agent, and 0.5 to 1.5 parts by weight of a surfactant, and the second component includes 65 to 85 parts by weight of polyisocyanate, 5 to 15 parts by weight of a modifier, 10 to 20 parts by weight of a plasticizer, and 10 to 15 parts by weight of a reactive flame retardant.

Abstract: Halite scales in an oilfield brine that has a potential for halite scaling can have halite scale formation inhibited or prevented by adding an effective amount of an additive, where the additive contains at least one non-water-soluble quaternary ammonium compound and at least one organic solvent. The quaternary ammonium compound may be benzyl-alkyldimethyl ammonium chloride, where the alkyl group has from 2 to 30 carbon atoms. The organic solvent may be one or more alcohol or glycol.

Abstract: Methods and compositions for treating subterranean formations with fluids containing superabsorbent polymer particles are provided. In one embodiment, the methods comprise introducing a treatment fluid into a well bore penetrating at least a portion of a subterranean formation, the treatment fluid including an aqueous base fluid, and one or more superabsorbent polymer particles comprising a plurality of monomers and one or more crosslinkers wherein at least one crosslinker is a labile crosslinker.

Abstract: Novel lipids, compositions, and methods of using the novel lipids and compositions are disclosed. Three-component lipid nanoparticle compositions comprising the novel lipids or other types of lipids, and methods of using the three-component lipid nanoparticle compositions are disclosed. Three-component lipid nanoparticle compositions contain a steroidal or structural lipid-containing component, a PEGylated lipid-containing component, a cationic or ionizable lipid-containing component, and are free of phospholipids. Pharmaceutical formulations including the three-component lipid nanoparticle compositions and further including therapeutic and/or prophylactics such as mRNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs.

Abstract: Treatment fluids and associated methods for treating a subterranean formation. An example method includes introducing a treatment fluid into a wellbore penetrating the subterranean formation. The treatment fluid includes a competitive metal binder selected from the group consisting of polyamino polyether methylene phosphonic acid, hydoxyethylamino-di(methylene phosphonic acid), and a combination thereof; a polymer capable of forming a polymer-metal complex; and an aqueous fluid. The method further includes contacting a metal ion with the treatment fluid after introduction of the treatment fluid into the wellbore and binding the metal ion with the competitive metal binder.

Abstract: Compositions and methods are provided for potent mRNA vaccines for prevention and treatment of 2019 novel Coronavirus (2019-nCoV) infections. The compositions include a pharmaceutical composition containing one or more mRNA molecules encoding spike protein epitopes, including mutated epitopes, or mRNA cocktails that encode critical viral genes together with pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Methods for stimulating system immune responses and treatment are provided, including subcutaneous, intraperitoneal and intramuscular injections.

Abstract: The present disclosure belongs to the technical field of gel material processing, and discloses processing equipment and a processing technology of a gel microsphere material.

Abstract: For each service scenario out of a plurality of service scenarios, matching features of a to-be-matched product corresponding to the service scenario are acquired based on user features of users accessing the service scenario. A respective user feature mapping value of the service scenario is calculated based on the matching features of the to-be-matched product corresponding to the service scenario. Out of the plurality of service scenarios, a target service scenario of the to-be-matched product is selected based on the respective user feature mapping value of the service scenario.

Abstract: Methods for treating a subterranean formation. An example method includes introducing a treatment fluid into a wellbore penetrating the subterranean formation. The treatment fluid includes an aqueous base fluid, a cationic or amphoteric friction reducer, and a substituted alkanolamine scale inhibitor. The method further includes contacting scale deposits on a surface in fluid communication with the wellbore and/or subterranean formation with the treatment fluid.

Abstract: Attribute features associated with a geographical location are obtained at a terminal device, and the plurality of attribute features are determined based on geographical and residential information data of the geographical location that is collected from one or more remote devices. For each particular attribute feature, a score value and a weight value corresponding to the particular attribute feature are determined. An attribute value for the geographical location that corresponds to each particular attribute feature is calculated using the score value and the weight value corresponding to the particular attribute feature. Display of the attribute value is initiated using a graphical user interface on a computer display device.

Abstract: A system measures parameters of the electricity drawn by an arc furnace and, based on an analysis of the parameters, provides indicators of whether arc coverage has been optimized. Factors related to optimization of arc coverage include electrode position, charge level, slag level and slag behaviour. More specifically, such indicators of whether arc coverage has been optimized may be used when determining a position for the electrode such that, to an extent possible, a stable arc cavity is maintained and an open arc condition is avoided. Conveniently, by avoiding open arc conditions, the internal linings of the furnace walls and roof may be protected from excessive wear and tear.

Abstract: Methods for treating a subterranean formation. An example method includes introducing a treatment fluid into a wellbore penetrating the subterranean formation. The treatment fluid includes an aqueous base fluid, a cationic or amphoteric friction reducer, and a substituted alkanolamine scale inhibitor. The method further includes contacting scale deposits on a surface in fluid communication with the wellbore and/or subterranean formation with the treatment fluid.

Abstract: Methods of fracturing a subterranean formation containing a hydrocarbon include introducing a first fracturing fluid that includes natural gas into the formation at a rate and pressure sufficient to create a complex fracture in the formation; introducing a second fracturing fluid into the formation, wherein the second fracturing fluid comprises water, a gelling agent, a foaming agent, natural gas, and proppant particulates; and allowing the second fracturing fluid to transport a portion of the proppant particulates into the complex fracture.