Abstract: A tissue-derived implant including: a plurality of decellularized extracellular cartilage particles, wherein each of the plurality of cartilage extracellular particles comprise one or more magnetic particles and mesenchymal stem cells and method of preparation and method use thereof. The tissue-derived implant can be guided to the site of a cartilage defect after administration by use of a magnetic field.

Abstract: Inverse origami design for soft robotic development is described herein. A method as described herein can include determining, by a system comprising a processor, shape parameters corresponding to an input shape; generating, by the system based on the shape parameters, an origami crease pattern representative of the input shape, wherein the origami crease pattern comprises respective origami cell units, and wherein the origami crease pattern is defined by a group of vector size parameters corresponding to relative fold lengths associated with the respective origami cell units, a vector angle parameter corresponding to fold angles associated with the respective origami cell units, and a scalar cell height parameter; and imprinting, by the system, the origami crease pattern onto a tangible medium.

Abstract: This disclosure provides an attenuated suid herpesvirus 1 (a Pseudorabies virus) wherein the TK, gl and gE genes thereof are modified relative to a parent field strain, such that the resultant virus is safe and effective for use as a live vaccine that protects swine animals from challenge with a virulent Pseudorabies virus.

Abstract: In cell instance segmentation of an original cell image obtained by microscopy, the original cell image is rotated by a rotation angle to yield a rotated cell image. A first machine-learning model for cell instance segmentation processes the original and rotated cell images such that effectively, horizontal and oblique boxes are used in bounding cells of the original cell image for enhancing cell-segmentation accuracy. A set of predictions is generated for each cell instance identified from the original and rotated cell images, yielding a plurality of sets of predictions for all cell instances. The plurality of sets of predictions is processed to remove any set having predicted space not simply connected, any unwanted set classified by a second machine-learning model as a poor indicator according to a certain performance criterion, and any redundant set. The plurality of sets of predictions then produces a segmentation map for the original cell image.

Abstract: One embodiment includes an electromagnetic device for generating a magnetic field in a workspace. The electromagnetic device includes an elongated sleeve defining a hollow space and having an external surface, a magnetic core, and an electric coil wounded onto the external surface of the elongated sleeve and configured to generate the magnetic field when energized. The magnetic core has a first end, a second end, and a middle portion that is disposed between the first end and the second end and received in the hollow space. The first end is provided with a core tip that is shaped substantially as a cone and has a cone radius greater than zero.

Abstract: In cell instance segmentation of an original cell image obtained by microscopy, the original cell image is rotated by a rotation angle to yield a rotated cell image. A first machine-learning model for cell instance segmentation processes the original and rotated cell images such that effectively, horizontal and oblique boxes are used in bounding cells of the original cell image for enhancing cell-segmentation accuracy. A set of predictions is generated for each cell instance identified from the original and rotated cell images, yielding a plurality of sets of predictions for all cell instances. The plurality of sets of predictions is processed to remove any set having predicted space not simply connected, any unwanted set classified by a second machine-learning model as a poor indicator according to a certain performance criterion, and any redundant set. The plurality of sets of predictions then produces a segmentation map for the original cell image.

Abstract: Two or more micropipettes are used to increase a microinjection throughput in an automated system for microinjecting adherent cells on a Petri dish. In the system, a motorized stage carrying the Petri dish sequentially visits the cells according to an optimized injection sequence. The sequence is selected by minimizing a total distance traveled by the motorized stage such that each cell is visited once by one of the micropipettes. Using multiple micropipettes advantageously reduces the minimized total distance over using a single micropipette to thereby increase the throughput. The optimized injection sequence is obtained by solving an equality-generalized traveling salesman problem. Each micropipette is mounted on a motorized micromanipulator. The motorized stage and motorized micromanipulators operate coordinately that each micromanipulator goes down or up during movement of the motorized stage to compensate for unevenness between a focus plane and a moving trajectory of the motorized stage.

Abstract: Disclosed is a bilayer bionic drug-loaded hydrogel, and preparation and application thereof. The hydrogel includes: an outer-layer hydrogel and an inner-layer hydrogel. The outer-layer hydrogel is prepared by: forming a polyvinyl alcohol hydrogel by directionally freezing a polyvinyl alcohol aqueous solution, soaking the polyvinyl alcohol aqueous solution in a sodium sulfate solution, and removing salt ions after soaking; and the inner-layer hydrogel is prepared by components of: a loaded drug, polyvinyl alcohol, chitosan, genipin, water, and a pH adjuster. The hydrogel of the present disclosure can be applied to deeply infected areas of wounds in open war wounds, and has protective, anti-inflammatory, haemostatic, reparative, anti-drug resistant bacterial effects, and other properties.

Abstract: A cooperative control module, an adaptive cruise system and a control method thereof, and a vehicle are provided. The adaptive cruise system comprises a vehicle sensor module, a driving environment intelligent sensing module, a vehicle state response estimation module, an adaptive cruise and controllable suspension cooperative control module, and a power control module. The control method of adaptive cruise is optional, one is according to the cruise speed set by the driver, and the other one is according to the cruise comfort set by the driver. In the case of adaptive cruising according to cruise comfort, the optimal cruise speed is intelligently calculated by the adaptive cruise and controllable suspension system based on driving conditions and driver's demands. The controllable suspension is controlled cooperatively during cruising, and the suspension control parameters are adaptively switched according to the performance requirements of the vehicle under different driving conditions.

Abstract: A cooperative control module, an adaptive cruise system and a control method thereof, and a vehicle are provided. The adaptive cruise system comprises a vehicle sensor module, a driving environment intelligent sensing module, a vehicle state response estimation module, an adaptive cruise and controllable suspension cooperative control module, and a power control module. The control method of adaptive cruise is optional, one is according to the cruise speed set by the driver, and the other one is according to the cruise comfort set by the driver. In the case of adaptive cruising according to cruise comfort, the optimal cruise speed is intelligently calculated by the adaptive cruise and controllable suspension system based on driving conditions and driver's demands. The controllable suspension is controlled cooperatively during cruising, and the suspension control parameters are adaptively switched according to the performance requirements of the vehicle under different driving conditions.

Abstract: An articulated finger. The articulated finger comprises a first phalange; a second phalange; a self-locking joint coupling the first phalange to the second phalange, wherein the self-locking joint is configured to allow motion in a first rotational direction of the first phalange relative to the second phalange and prevent motion in a second rotational direction of the first phalange relative to the second phalange, wherein the first rotational direction is opposite the second rotational direction; and a compliant actuator configured to actuate the first phalange in the first rotational direction relative to the second phalange.

Abstract: This disclosure provides an attenuated suid herpesvirus 1 (a Pseudorabies virus) wherein the TK, gI and gE genes thereof are modified relative to a parent field strain, such that the resultant virus is safe and effective for use as a live vaccine that protects swine animals from challenge with a virulent Pseudorabies virus.

Abstract: Inverse origami design for soft robotic development is described herein. A method as described herein can include determining, by a system comprising a processor, shape parameters corresponding to an input shape; generating, by the system based on the shape parameters, an origami crease pattern representative of the input shape, wherein the origami crease pattern comprises respective origami cell units, and wherein the origami crease pattern is defined by a group of vector size parameters corresponding to relative fold lengths associated with the respective origami cell units, a vector angle parameter corresponding to fold angles associated with the respective origami cell units, and a scalar cell height parameter; and imprinting, by the system, the origami crease pattern onto a tangible medium.

Abstract: One embodiment includes an electromagnetic device for generating a magnetic field in a workspace. The electromagnetic device includes an elongated sleeve defining a hollow space and having an external surface, a magnetic core, and an electric coil wounded onto the external surface of the elongated sleeve and configured to generate the magnetic field when energized. The magnetic core has a first end, a second end, and a middle portion that is disposed between the first end and the second end and received in the hollow space. The first end is provided with a core tip that is shaped substantially as a cone and has a cone radius greater than zero.

Abstract: The present disclosure discloses a contact angle measuring device, including a light source, a container, a photodetector, a bubble generating unit, and a processing unit. The container includes a first and a second side walls that are opposite. The first side wall is made of a light-transmitting material, the container is filled with a liquid with light transmission inside. The monochromatic light emitted by the light source passes through the first side wall and enters an interface between the first side wall and the liquid. The bubble generating unit is configured for generating a bubble that is in contact with an inner surface of the first side wall. The photodetector is configured for detecting light intensity distribution of the monochromatic light through the liquid.

Abstract: Disclosed is a bilayer bionic drug-loaded hydrogel, and preparation and application thereof. The hydrogel includes: an outer-layer hydrogel and an inner-layer hydrogel. The outer-layer hydrogel is prepared by: forming a polyvinyl alcohol hydrogel by directionally freezing a polyvinyl alcohol aqueous solution, soaking the polyvinyl alcohol aqueous solution in a sodium sulfate solution, and removing salt ions after soaking; and the inner-layer hydrogel is prepared by components of: a loaded drug, polyvinyl alcohol, chitosan, genipin, water, and a pH adjuster. The hydrogel of the present disclosure can be applied to deeply infected areas of wounds in open war wounds, and has protective, anti-inflammatory, haemostatic, reparative, anti-drug resistant bacterial effects, and other properties.

Abstract: The present application describes the use of a solid electrolyte interphase (SEI) fluorinating precursor and/or an SEI fluorinating compound to coat an electrode material and create an artificial SEI layer. These modifications may increase surface passivation of the electrodes, SEI robustness, and structural stability of the silicon-containing electrodes.

Abstract: A system for quantitative control of mitochondrial transfer based on droplet microfluidics includes a droplet generation module configured to generate droplets containing isolated mitochondria and a single cell; a droplet observation module configured for observation of the generated droplets under a microscope; and a droplet collection module configured to collect the generated droplets. The number of mitochondria needed to be transferred into recipient cells is an import issue in precise medicine. The development of the presented invention, which can achieve a precise quantity-control on mitochondrial transfer at the single cell level, can help us to determine the mitochondria number needed to make a significant function improvement on the recipient cells before conducting the cell therapy for mtDNA-related diseases.

Abstract: A method of making a magnetically-drivable microrobot that is suitable for carrying and delivering cells includes photo-curing a photo-curable material composition to form a body of the magnetically-drivable microrobot. The photo-curable material composition includes a degradable component, a structural component, a magnetic component, and a photo-curing facilitation composition including a photoinitiator component and a photosensitizer component.

Abstract: One embodiment provides a method for controlling a microagent in a workspace. The method includes providing a plurality of magnetic sources and generating a rotating gradient magnetic field by activating the plurality of magnetic sources differently such that a driving force is created to drive the microagent towards an aggregation center in the workspace.