Abstract: A method of cleaving a substrate and a method of manufacturing a bonded substrate using the same, in which warping in a cleaved substrate is reduced. The method includes the following steps of: forming an ion implantation layer by implanting ions into a substrate; annealing the substrate in which the ion implantation layer is formed; implanting ions again into the ion implantation layer of the substrate; and cleaving the substrate along the ion implantation layer by heating the substrate into which ions are implanted.

Abstract: Disclosed herein is a pharmaceutical composition for the prevention and treatment of restenosis following a blood vessel injury procedure, comprising obovatol as an active ingredient.

Abstract: Methods and apparatus are disclosed for coating endoprostheses. The methods use distributive forces such as centrifugal force or vibration to distribute a bioactive liquid over the surface of the endoprosthesis. In some embodiments, the endoprosthesis is elongated along the longitudinal axis, and is substantially tubular, such as a stent. In other embodiments, the force is applied by rotating the endoprosthesis at speeds between 100-100,000 RPM, or by vibrating it at frequencies between about 10 Hz and about 200,000 Hz. The invention also includes a device for providing a predictable coating on the surface of an endoprosthesis, which includes means for applying bioactive liquid to the endoprosthesis, and means for applying centrifugal force or vibration to distribute the bioactive liquid. The invention also includes endoprostheses that have been subjected to centrifugal force to distribute a bioactive liquid coating layer.

Abstract: Disclosed is a method for producing anti-E. coli O157 antibodies. Anti-E. coli O157:H7 antibodies are produced in egg-laying hens and isolated from the eggs. E. coli O157:H7 is cultured in a brain heart infusion broth and killed by the treatment with hot water for 5-10 min. After being collected by centrifugation, the dead bacteria is homogenized. Serving as an antigenic material, the bacterial homogenate is injected into egg-laying hens to induce antibodies against E. coli O157:H7 in the eggs. The induced antibodies are isolated from the yolk of the eggs and the eggs containing the antibodies against E. coli O157:H7 can be utilized, in their entirety, for foods. Alternatively, the yolks are separated from the eggs and freeze-dried. The resulting dried egg component can be applied to processed foodstuffs, alone or in combination with whole eggs. Since the antibodies against E. coli O157:H7 are contained in frozen eggs, it is very convenient to store the antibodies.