Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Abstract: The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor.

Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from a-CTLA4, ?-PD-1, and ?-PD-L1.

Abstract: The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Abstract: The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.

Abstract: The applications provides the anti-CD3 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to active CD3+ T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: The present invention discloses an ultra wide band digital phase shifter, wherein the phase shifter includes a coupler, a first impedance network and a second impedance network. The coupler is cascaded by spiral inductor coupling units; each stage of spiral inductive coupling unit includes a first spiral inductor and a second spiral inductor coupled mutually; multistage cascade of the spiral inductor coupling units is implemented through the series connection of each stage of first spiral inductors and the series connection of each stage of second spiral inductors; and the coupling interval or microstrip band width of each stage of spiral inductor coupling unit in the coupler from the exterior to the interior decreases gradually.

Abstract: The present invention discloses an ultra wide band fixed phase shifter based on a capacitive load, which includes N physically separated phase shift units, and each phase shift unit includes an orthocoupler, first and second transmission lines, and first and second capacitive loads, wherein the orthocoupler includes an input end, a coupling end, a direct-connection end and an isolation end, one end of the first transmission line serves as a signal input end of the phase shift unit and the other end is connected with the input end of the orthocoupler, one end of the second transmission line serves as a signal output end of the phase shift unit and the other end is connected with the isolation end of the orthocoupler; one end of the first capacitive load is connected with the coupling end of the orthocoupler and the other end is grounded; one end of the second capacitive load is connected with the direct-connection end of the orthocoupler and the other end is grounded.

Abstract: The present invention discloses an ultra wide band fixed phase shifter based on a capacitive load, which includes N physically separated phase shift units, and each phase shift unit includes an orthocoupler, first and second transmission lines, and first and second capacitive loads, wherein the orthocoupler includes an input end, a coupling end, a direct-connection end and an isolation end, one end of the first transmission line serves as a signal input end of the phase shift unit and the other end is connected with the input end of the orthocoupler, one end of the second transmission line serves as a signal output end of the phase shift unit and the other end is connected with the isolation end of the orthocoupler; one end of the first capacitive load is connected with the coupling end of the orthocoupler and the other end is grounded; one end of the second capacitive load is connected with the direct-connection end of the orthocoupler and the other end is grounded.

Abstract: The present invention discloses an ultra wide band digital phase shifter, wherein the phase shifter includes a coupler, a first impedance network and a second impedance network. The coupler is cascaded by spiral inductor coupling units; each stage of spiral inductive coupling unit includes a first spiral inductor and a second spiral inductor coupled mutually; multistage cascade of the spiral inductor coupling units is implemented through the series connection of each stage of first spiral inductors and the series connection of each stage of second spiral inductors; and the coupling interval or microstrip band width of each stage of spiral inductor coupling unit in the coupler from the exterior to the interior decreases gradually.

Abstract: A centrifugal impeller includes a body of antistatic plastic and a back plate made of metal, preferably aluminum. The back plate is fixed to the body is such a way that the back plate can not make accidental contact with a volute of a blower in which the impeller is deployed.

Abstract: A centrifugal impeller includes a body of antistatic plastic and a back plate made of metal, preferably aluminium. The back plate is fixed to the body is such a way that the back plate can not make accidental contact with a volute of a blower in which the impeller is deployed.

Abstract: A method for transmitting network packets is provided. Reordered network packets received by a receiving end are put into a buffer queue. When a waiting time expires or when a network packet with a sequence number equal to the current transmission sequence number is received, the receiving end picks and transmits appropriate network packets from the buffer queue. Therefore, reordered network packets are sorted and then sent out sequentially, thereby avoiding waste of network bandwidth caused by retransmitting network packets, and improving the transmitting efficiency of the network.

Abstract: A method for transmitting network packets is provided. Reordered network packets received by a receiving end are put into a buffer queue. When a waiting time expires or when a network packet with a sequence number equal to the current transmission sequence number is received, the receiving end picks and transmits appropriate network packets from the buffer queue. Therefore, reordered network packets are sorted and then sent out sequentially, thereby avoiding waste of network bandwidth caused by retransmitting network packets, and improving the transmitting efficiency of the network.

Abstract: A light-signal delaying device according to the present invention includes a linear guide rail and a pair of stages mounted on the linear guide rail. The device further includes a V-groove holder mounted on one of the stages, a pair of optical fiber collimators secured to the V-groove holder, a pair of reflecting mirrors mounted on the other stage such that reflecting surfaces thereof meet each other at 90°, and an actuator engaging section for moving the stage along the linear guide rail.

Abstract: This invention provides a flexible polymer modified waterproofing cement material which can be used on a substrate or in concealed areas of construction engineering, water conservancy projects, municipal works, and its making process. The waterproofing material is made by kneading a hydraulic cement, a polymer dispersion, a water-soluble polymer or re-dispersible resin and water at a weight ratio of cement/polymer of about 100:15 to about 100:150 under conditions of about 25° C. to about 120° C., about 20 rpm to about 80 rpm until the water content of the kneaded materials reaches about 5% to about 20%. The kneaded material is mixed with a toughening polymer at a weight ratio of about 100:10 to about 100:50, then is calendered into sheets. These materials can adhere to dry or wet substrates firmly. They can be used in cold or hot and wet climate areas. After application, the waterproofing structure formed can bear retractive stress and deformation of the base or can resist outer impact.