Abstract: The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.

Abstract: In one embodiment, providing, by a client device, device information and key data over a network to a server device, the device information uniquely identifying the client device; generating a device key, by a device key generation logic, at the server device based on the device information; receiving a module from the server device, the module comprising a bound content key and the device key generation logic, wherein the bound content key is encrypted by the device key at the server device; and processing protected content using the module.

Abstract: The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

Abstract: An electrical component includes a plurality of core devices arranged within a housing so as to be electrically isolated from one another. For each of the plurality of core devices, a first contact pad and a second contact pad is formed on an outside surface of the housing. The first and second contact pads are electrically connected to a respective core device of the plurality of core devices.

Abstract: A data structure for a flash memory and data reading/writing method thereof are disclosed. A 512 bytes data and a redundant code derived from the data encoded with a 6-bit error correcting code scheme are stored in a first sector and a second sector with sequential address in a block of the flash memory respectively. A logic block address information of this block is divided into two parts that are stored in the first sector and the second sector respectively.

Abstract: Learning processes for a single hidden layer neural network, including linear input units, nonlinear hidden units, and linear output units, calculate the lower-layer network parameter gradients by taking into consideration a solution for the upper-layer network parameters. The upper-layer network parameters are calculated by a closed form formula given the lower-layer network parameters. An accelerated gradient algorithm can be used to update the lower-layer network parameters. A weighted gradient also can be used. With the combination of these techniques, accelerated training with faster convergence, to a point with a lower error rate, can be obtained.

Abstract: In an automatic speech recognition system, a feature extractor extracts features from a speech signal, and speech is recognized by the automatic speech recognition system based on the extracted features. Noise reduction as part of the feature extractor is provided by feature enhancement in which feature-domain noise reduction in the form of Mel-frequency cepstra is provided based on the minimum means square error criterion. Specifically, the devised method takes into account the random phase between the clean speech and the mixing noise. The feature-domain noise reduction is performed in a dimension-wise fashion to the individual dimensions of the feature vectors input to the automatic speech recognition system, in order to perform environment-robust speech recognition.

Abstract: A statistical language model is trained for use in a directory assistance system using the data in a directory assistance listing corpus. Calculations are made to determine how important words in the corpus are in distinguishing a listing from other listings, and how likely words are to be omitted or added by a user. The language model is trained using these calculations.

Abstract: A method is disclosed herein that includes an act of causing a processor to access a deep-structured, layered or hierarchical model, called deep convex network, retained in a computer-readable medium, wherein the deep-structured model comprises a plurality of layers with weights assigned thereto. This layered model can produce the output serving as the scores to combine with transition probabilities between states in a hidden Markov model and language model scores to form a full speech recognizer. The method makes joint use of nonlinear random projections and RBM weights, and it stacks a lower module's output with the raw data to establish its immediately higher module. Batch-based, convex optimization is performed to learn a portion of the deep convex network's weights, rendering it appropriate for parallel computation to accomplish the training.

Abstract: An automatic speech recognition system recognizes user changes to dictated text and infers whether such changes result from the user changing his/her mind, or whether such changes are a result of a recognition error. If a recognition error is detected, the system uses the type of user correction to modify itself to reduce the chance that such recognition error will occur again. Accordingly, the system and methods provide for significant speech recognition learning with little or no additional user interaction.

Abstract: Provided are an organic semiconductor compound using thiazole, and an organic thin film transistor having an organic semiconductor layer formed of the organic semiconductor compound using thiazole. The novel organic semiconductor compound including thiazole has liquid crystallinity and excellent thermal stability, and thus is provided to form an organic semiconductor layer in the organic thin film transistor. To this end, a silicon oxide layer is formed on a silicon substrate, and an organic semiconductor layer including thiazole is formed on the silicon oxide layer. In addition, source and drain electrodes are formed on both edge portions of the organic semiconductor layer. The organic thin film transistor using the organic semiconductor layer has an improved on/off ratio and excellent thermal stability. Also, a solution process can be applied in its manufacture.

Abstract: Nanostructured layers with 10 nm to 50 nm pores spaced 10-50 nm apart, a method for making such nanostructured layers, optoelectronic devices having such nanostructured layers and uses for such nanostructured layers are disclosed. The nanostructured layer can be formed using precursor sol, which generally includes one or more covalent metal complexes, one or more surfactants, a solvent, one or more optional condensation inhibitors, and (optionally) water. Evaporating the solvent from the precursor sol forms a surfactant-templated film. Covalently crosslinking the surfactant-templated film forms a nanostructured porous layer. Pore size is controlled, e.g., by appropriate solvent concentration, choice of surfactant, use of chelating agents, use of swelling agents or combinations of these.

Abstract: CIGS absorber layers fabricated using coated semiconducting nanoparticles and/or quantum dots are disclosed. Core nanoparticles and/or quantum dots containing one or more elements from group 13 and/or IIIA and/or VIA may be coated with one or more layers containing elements group IB, IIIA or VIA. Using nanoparticles with a defined surface area, a layer thickness could be tuned to give the proper stoichiometric ratio, and/or crystal phase, and/or size, and/or shape. The coated nanoparticles could then be placed in a dispersant for use as an ink, paste, or paint. By appropriate coating of the core nanoparticles, the resulting coated nanoparticles can have the desired elements intermixed within the size scale of the nanoparticie, while the phase can be controlled by tuning the stochiomctiy, and the stoichiometry of the coated nanoparticle may be tuned by controlling the thickness of the coating(s).

Abstract: The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3? ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5? end.

Abstract: A speech recognition system includes a receiver component that receives a distorted speech utterance. The speech recognition also includes an adaptor component that selectively adapts parameters of a compressed model used to recognize at least a portion of the distorted speech utterance, wherein the adaptor component selectively adapts the parameters of the compressed model based at least in part upon the received distorted speech utterance.

Abstract: A method for fabricating a graphene thin film by reducing graphene oxide and a method for fabricating an optoelectronic device using the same are provided. The method for fabricating a graphene thin film comprises: (a) preparing graphene oxide; (b) preparing graphene through reducing the graphene oxide by a sulfonyl hydrazide-based reducing agent; (c) preparing a graphene dispersed solution by dispersing the graphene into an organic solvent; and (d) fabricating a graphene thin film by applying the graphene dispersed solution. The sulfonyl hydrazide-based reducing agent may be a compound having a sulfonyl hydrazide substituent of Chemical Formula 1 in the present disclosure in which A may be any one in Chemical Formula 2 in the present disclosure.

Abstract: A method of generating a confidence measure generator is provided for use in a voice search system, the voice search system including voice search components comprising a speech recognition system, a dialog manager and a search system. The method includes selecting voice search features, from a plurality of the voice search components, to be considered by the confidence measure generator in generating a voice search confidence measure. The method includes training a model, using a computer processor, to generate the voice search confidence measure based on selected voice search features.

Abstract: A multi-modal human computer interface (HCI) receives a plurality of available information inputs concurrently, or serially, and employs a subset of the inputs to determine or infer user intent with respect to a communication or information goal. Received inputs are respectively parsed, and the parsed inputs are analyzed and optionally synthesized with respect to one or more of each other. In the event sufficient information is not available to determine user intent or goal, feedback can be provided to the user in order to facilitate clarifying, confirming, or augmenting the information inputs.

Abstract: A speech recognition system described herein includes a receiver component that receives a distorted speech utterance. The speech recognition also includes an updater component that is in communication with a first model and a second model, wherein the updater component automatically updates parameters of the second model based at least in part upon joint estimates of additive and convolutive distortions output by the first model, wherein the joint estimates of additive and convolutive distortions are estimates of distortions based on a phase-sensitive model in the speech utterance received by the receiver component. Further, distortions other than additive and convolutive distortions, including other stationary and nonstationary sources, can also be estimated used to update the parameters of the second model.

Abstract: An ink for forming CIGS photovoltaic cell active layers is disclosed along with methods for making the ink, methods for making the active layers and a solar cell made with the active layer. The ink contains a mixture of nanoparticles of elements of groups IB, IIIA and (optionally) VIA. The particles are in a desired particle size range of between about 1 nm and about 500 nm in diameter, where a majority of the mass of the particles comprises particles ranging in size from no more than about 40% above or below an average particle size or, if the average particle size is less than about 5 nanometers, from no more than about 2 nanometers above or below the average particle size. The use of such ink avoids the need to expose the material to an H2Se gas during the construction of a photovoltaic cell and allows more uniform melting during film annealing, more uniform intermixing of nanoparticles, and allows higher quality absorber films to be formed.