Abstract: This disclosure describes a novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.

Abstract: A lamp-fixing device includes a base and at least one receiving unit. The receiving unit is formed on the base. The receiving unit includes two opposite protruding walls extending perpendicular out from the base. The two protruding walls and the base cooperatively define a receiving space used to receive one end of a lamp tube with an electrode holder. The two protruding walls and the base each define a heat dissipation hole therein of the receiving space.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.

Abstract: A direct type backlight module (30) includes a base (21), at least two lamp-fixing units (22) and at least one lamp tube (20). Each lamp-fixing unit is disposed on each corresponding opposite ends of the base. Each lamp-fixing unit includes a bottom board (222) and at least one clip element (224) formed on the bottom board. The lamp tube includes two electrodes defined at two ends thereof and two electrode holders (202) receiving the two electrodes respectively. The electrode holders of the lamp tube are fixed in the corresponding clip elements of the two lamp-fixing units, thus the lamp tube are mounted into the two aligned lamp-fixing units. In the present backlight module, the lamp tubes can be fixed into the clip elements tightly and also easily dissembled from the clip elements of the lamp-fixing units.

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract: A lamp-fixing device includes a base and at least one receiving unit. The receiving unit is formed on the base. The receiving unit includes two opposite protruding walls extending perpendicular out from the base. The two protruding walls and the base cooperatively define a receiving space used to receive one end of a lamp tube with an electrode holder. The two protruding walls and the base each define a heat dissipation hole therein of the receiving space. A backlight module using the lamp-fixing device is also provided. The present lamp-fixing device can help to dissipate heat from lamp tubes fixed thereon efficiently.

Abstract: A direct type backlight module (30) includes a base (21), at least two lamp-fixing units (22) and at least one lamp tube (20). Each lamp-fixing unit is disposed on each corresponding opposite ends of the base. Each lamp-fixing unit includes a bottom board (222) and at least one clip element (224) formed on the bottom board. The lamp tube includes two electrodes defined at two ends thereof and two electrode holders (202) receiving the two electrodes respectively. The electrode holders of the lamp tube are fixed in the corresponding clip elements of the two lamp-fixing units, thus the lamp tube are mounted into the two aligned lamp-fixing units. In the present backlight module, the lamp tubes can be fixed into the clip elements tightly and also easily dissembled from the clip elements of the lamp-fixing units.

Abstract: A bottom-lighting type backlight module includes a frame, a light guide member and a plurality of linear light sources. The frame includes a base and a plurality of sidewalls extending from the periphery of the base to define an opening. The light guide member is disposed on the opening of the frame, the light guide member having a prism surface away from the base of the frame. The light sources are arranged in the frame under the light guide member. The base of the frame defines a plurality of projections extending out from thereof towards the opening along a direction perpendicular to the light sources, and a plurality of curving surfaces are defined by the base of the frame between two adjacent projections, each curving surface facing the adjacent light source. The present backlight module may have good optical uniformity and high brightness without the help of light diffusion plate.

Abstract: This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.

Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.