Patents by Inventor Dongbo CAI

Dongbo CAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Application of glutamate dehydrogenase GDHA of in increasing yield of poly-r-glutamic acid from
    Patent number: 11952596
    Abstract: Application of glutamate dehydrogenase GdhA of Peptostreptococcus asaccharolyticus in increasing the yield of poly-?-glutamic acid from Bacillus licheniformis. The glutamate dehydrogenase GdhA of the Bacillus licheniformis WX-02 per se is replaced with the glutamate dehydrogenase derived from the Peptostreptococcus asaccharolyticus by means of homologous recombination, which significantly increases the level of synthesizing the poly-?-glutamic acid for the Bacillus licheniformis, and the yield of the obtained poly-?-glutamic acid from strains is increased at least by more than 20% compared with control strains.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: April 9, 2024
    Assignee: Hubei University
    Inventors: Shouwen Chen, Fan Yang, Dongbo Cai, Yaozhong Chen, Qing Zhang, Xin Ma, Jiangang Chen
  • malR-knockout strain, construction method and use
    Patent number: 11111516
    Abstract: Provided are malR-knockout Bacillus licheniformis strain, a construction method and a use. Using a genetic engineering method, gene, namely, the malR gene, which is in charge of conducting the transcription of the carbon metabolism transcription factor MalR, in the genome of Bacillus licheniformis DW2 is knocked out, thereby successfully obtaining Bacillus licheniformis DW2?malR, from which the malR gene has been deleted. In comparison with Bacillus licheniformis DW2, the strain obtained by the construction can improve the Bacitracin yield in a fermentation broth during Bacitracin fermentation by at least 23%.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: September 7, 2021
    Inventors: Shouwen Chen, Fei Wu, Dongbo Cai, Bowen Zhang, Junhui Li, Lijun Lou, Xiangqi Qiu
  • APPLICATION OF GLUTAMATE DEHYDROGENASE GDHA OF PEPTOSTREPTOCOCCUS ASACCHAROLYTICUS IN INCREASING YIELD OF POLY- r -GLUTAMIC ACID FROM BACILLUS LICHENIFORMIS
    Publication number: 20210171918
    Abstract: Application of glutamate dehydrogenase GdhA of Peptostreptococcus asaccharolyticus in increasing the yield of poly-?-glutamic acid from Bacillus licheniformis. The glutamate dehydrogenase GdhA of the Bacillus licheniformis WX-02 per se is replaced with the glutamate dehydrogenase derived from the Peptostreptococcus asaccharolyticus by means of homologous recombination, which significantly increases the level of synthesizing the poly-?-glutamic acid for the Bacillus licheniformis, and the yield of the obtained poly-?-glutamic acid from strains is increased at least by more than 20% compared with control strains.
    Type: Application
    Filed: September 30, 2020
    Publication date: June 10, 2021
    Inventors: Shouwen CHEN, Fan YANG, Dongbo CAI, Yaozhong CHEN, Qing ZHANG, Xin MA, Jiangang CHEN
  • MALR-KNOCKOUT BACILLUS LICHENIFORMIS STRAIN, CONSTRUCTION METHOD AND USE
    Publication number: 20210095324
    Abstract: Provided are malR-knockout Bacillus licheniformis strain, a construction method and a use. Using a genetic engineering method, gene, namely, the malR gene, which is in charge of conducting the transcription of the carbon metabolism transcription factor MalR, in the genome of Bacillus licheniformis DW2 is knocked out, thereby successfully obtaining Bacillus licheniformis DW2?malR, from which the malR gene has been deleted. In comparison with Bacillus licheniformis DW2, the strain obtained by the construction can improve the Bacitracin yield in a fermentation broth during Bacitracin fermentation by at least 23%.
    Type: Application
    Filed: August 5, 2019
    Publication date: April 1, 2021
    Inventors: Shouwen CHEN, Fei WU, Dongbo CAI, Bowen ZHANG, Junhui LI, Lijun LOU, Xiangqi QIU