Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.

Abstract: The present disclosure discloses a high-temperature fast-curing starch-based adhesive for particleboards and a preparation method thereof, belonging to the technical field of adhesive preparation. The low viscosity of the starch-based adhesive is ensured by selecting a crosslinking monomer which does not self-crosslink in a reaction process in the present disclosure, and a binary crosslinking agent matched with the crosslinking monomer is added before use to be quickly crosslinked with the crosslinking monomer at high temperature so as to ensure better thermosetting property and water resistance as well as faster curing speed of the starch-based adhesive at the same time, which meets the requirements of the particleboards for the adhesive, solves the problem of long curing time of the existing starch-based adhesives at high temperatures, further shortens the curing time of the starch-based adhesives to about 60 s, and improves the production efficiency of the particleboards.

Abstract: This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

Abstract: The present disclosure relates to a micron silver particle-reinforced 316L stainless steel matrix composite, including a 316L stainless steel matrix and silver particles uniformly distributed in the 316L stainless steel matrix. The silver particles have a weight 1% to 5% of the total weight of the composite; and the composite has a density of 7.9 g/cm3 to 8.2 g/cm3 and a relative density of more than 98%. The composite is prepared by the following method: mixing raw materials of a spherical silver powder and a spherical 316L stainless steel powder; subjecting a resulting mixture to mechanical ball milling to obtain a mixed powder; sieving the mixed powder and adding a resulting powder to a powder cylinder of an SLM forming machine; and charging an inert protective gas for printing to obtain the composite.

Abstract: This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

Abstract: The present disclosure discloses a high-temperature fast-curing starch-based adhesive for particleboards and a preparation method thereof, belonging to the technical field of adhesive preparation. The low viscosity of the starch-based adhesive is ensured by selecting a crosslinking monomer which does not self-crosslink in a reaction process in the present disclosure, and a binary crosslinking agent matched with the crosslinking monomer is added before use to be quickly crosslinked with the crosslinking monomer at high temperature so as to ensure better thermosetting property and water resistance as well as faster curing speed of the starch-based adhesive at the same time, which meets the requirements of the particleboards for the adhesive, solves the problem of long curing time of the existing starch-based adhesives at high temperatures, further shortens the curing time of the starch-based adhesives to about 60 s, and improves the production efficiency of the particleboards.

Abstract: A coaxial powder-feeding nozzle includes a partition wall-type shell, a powder flow area, a cooling liquid flow area and a shielding gas conveying channel. A powder self-cleaning filter is on the outer side of the partition wall-type shell; the powder self-cleaning filter includes a set of powder collecting tubes on each side of the partition wall-type shell in the axial direction; each set of powder collecting tubes includes at least one powder collecting tube; under the coaction of a suction force applied by a powder collecting system and the self-weight of residual powder, a residual powder inlet of each powder collecting tube causes the residual powder on the opposite side to roll down to the bottom along the wall surface of a metal tube to be processed on the same side, and to be gathered at the front end of the residual powder inlet of the powder collecting tube.

Abstract: A chiral cell includes a cell structure. The cell structure includes an upper ring, a middle ring, a lower ring, upper connecting rods, and lower connecting rods. The upper ring and the lower ring have the same geometrical shape, and the middle ring is located between the upper ring and the lower ring. A plurality of upper connecting rods is provided; the two ends of each upper connecting rod are respectively correspondingly connected to the upper ring and the middle ring and the upper connecting rods are obliquely and uniformly distributed between the upper ring and the middle ring; a plurality of lower connecting rods is provided; the two ends of each lower connecting rod are respectively correspondingly connected to the lower ring and the middle ring and the lower connecting rods are obliquely and uniformly distributed between the lower ring and the middle ring.

Abstract: A coaxial powder-feeding nozzle includes a partition wall-type shell, a powder flow area, a cooling liquid flow area and a shielding gas conveying channel. A powder self-cleaning filter is on the outer side of the partition wall-type shell; the powder self-cleaning filter includes a set of powder collecting tubes on each side of the partition wall-type shell in the axial direction; each set of powder collecting tubes includes at least one powder collecting tube; under the coaction of a suction force applied by a powder collecting system and the self-weight of residual powder, a residual powder inlet of each powder collecting tube causes the residual powder on the opposite side to roll down to the bottom along the wall surface of a metal tube to be processed on the same side, and to be gathered at the front end of the residual powder inlet of the powder collecting tube.

Abstract: A chiral cell includes a cell structure. The cell structure includes an upper ring, a middle ring, a lower ring, upper connecting rods, and lower connecting rods. The upper ring and the lower ring have the same geometrical shape, and the middle ring is located between the upper ring and the lower ring. A plurality of upper connecting rods is provided; the two ends of each upper connecting rod are respectively correspondingly connected to the upper ring and the middle ring and the upper connecting rods are obliquely and uniformly distributed between the upper ring and the middle ring; a plurality of lower connecting rods is provided; the two ends of each lower connecting rod are respectively correspondingly connected to the lower ring and the middle ring and the lower connecting rods are obliquely and uniformly distributed between the lower ring and the middle ring.

Abstract: The present disclosure relates to a micron silver particle-reinforced 316L stainless steel matrix composite, including a 316L stainless steel matrix and silver particles uniformly distributed in the 316L stainless steel matrix. The silver particles have a weight 1% to 5% of the total weight of the composite; and the composite has a density of 7.9 g/cm3 to 8.2 g/cm3 and a relative density of more than 98%. The composite is prepared by the following method: mixing raw materials of a spherical silver powder and a spherical 316L stainless steel powder; subjecting a resulting mixture to mechanical ball milling to obtain a mixed powder; sieving the mixed powder and adding a resulting powder to a powder cylinder of an SLM forming machine; and charging an inert protective gas for printing to obtain the composite.