Patents by Inventor Dongfang Liu

Dongfang Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9502240
    Abstract: Provided is a preparation method of a crystalline silicon film.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: November 22, 2016
    Assignee: SHANGHAI ADVANCED RESEARCH INSTITUTE, CHINESE ACADEMY OF SCIENCES
    Inventors: Dongfang Liu, Wei Zhang, Xiaoyuan Chen, Hui Yang, Cong Wang, Linfeng Lu
  • Publication number: 20160104615
    Abstract: Provided is a preparation method of a crystalline silicon film. The method includes: 1) forming a mask for making a periodic silicon rod array on a monocrystalline silicon wafer substrate, and forming the periodic silicon rod array on the monocrystalline silicon substrate by a wet chemical etching or dry etching process; 2) forming barrier layers on the surface of the monocrystalline silicon substrate and the surface of the silicon rod array for next selectively epitaxial growth of silicon; 3) exposing silicon cores on the heads of the rod array by a selective etching process to form a silicon seed array; 4) growing a continuous silicon film at the top of the rod array by a chemical vapor deposition method using the exposed silicon cores as seeds for selectively epitaxial growth of silicon; and 5) lifting off the silicon film and transferring the silicon film to a preset substrate, and the seeded substrate is reusable.
    Type: Application
    Filed: May 7, 2014
    Publication date: April 14, 2016
    Inventors: Dongfang LIU, Wei ZHANG, Xiaoyuan CHEN, Hui YANG, Cong WANG, Linfeng LU
  • Patent number: 8512969
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: August 20, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Publication number: 20130017565
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: May 7, 2012
    Publication date: January 17, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Patent number: 8173384
    Abstract: The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: May 8, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Publication number: 20120027744
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: March 30, 2011
    Publication date: February 2, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: DONGFANG LIU, KEVIN POJASEK, ZACHARY SHRIVER, KRISTINE HOLLEY, YOSUF EL-SHABRAWI, GANESH VENKATARAMAN, RAM SASISEKHARAN
  • Patent number: 7939292
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: May 10, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Patent number: 7709461
    Abstract: The invention relates to methods for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects. The polysaccharides may be formulated or unformulated and in some instances have an extremely fast absorption rate.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: May 4, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Yiwei Qi, Ganesh Venkataraman, Mallikarjun Sundaram, Ram Sasisekharan
  • Patent number: 7687479
    Abstract: The invention relates, in part, to methods and products related to producing low molecular weight heparin.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: March 30, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Publication number: 20100062468
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: July 27, 2009
    Publication date: March 11, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Patent number: 7585642
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: September 8, 2009
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Patent number: 7560106
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: July 14, 2009
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
  • Publication number: 20090105463
    Abstract: The invention relates, in part, to compositions comprising glycosaminoglycans, fragments of glycosaminoglycans or glycosaminoglycan fractions. The compositions provided can be used in various methods of modulating FGF and/or VEGF activity. The method can be in vitro or in vivo methods. Therefore, the invention also relates, in part, to methods of treating a subject with the compositions provided.
    Type: Application
    Filed: March 29, 2006
    Publication date: April 23, 2009
    Applicant: Massachusetts Institute of Technology
    Inventors: David A. Berry, Kevin Pojasek, Dongfang Liu, Chi-Pong Kwan, Yiwei Qi, Ram Sasisekharan
  • Publication number: 20090081635
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: October 29, 2008
    Publication date: March 26, 2009
    Applicant: Massachusetts Institute of Technology
    Inventors: DONGFANG LIU, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Patent number: 7455986
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis , etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: November 25, 2008
    Assignee: Massachusetts Institute of Technology, Inc.
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Patent number: 7399604
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: July 15, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Patent number: 7390633
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: June 24, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Publication number: 20070172425
    Abstract: The invention includes an in vivo pharmacodynamic method for testing a compound for cell cycle regulation.
    Type: Application
    Filed: May 27, 2004
    Publication date: July 26, 2007
    Inventor: DongFang Liu
  • Publication number: 20070161073
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: November 30, 2006
    Publication date: July 12, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Publication number: 20070148158
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Application
    Filed: December 20, 2006
    Publication date: June 28, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman