Patents by Inventor Dongfang Liu

Dongfang Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and producing low molecular weight heparin
    Patent number: 7687479
    Abstract: The invention relates, in part, to methods and products related to producing low molecular weight heparin.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: March 30, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • METHODS AND PRODUCTS RELATED TO LOW MOLECULAR WEIGHT HEPARIN
    Publication number: 20100062468
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: July 27, 2009
    Publication date: March 11, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Methods for evaluating the quality of a heparin sample
    Patent number: 7585642
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: September 8, 2009
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Rationally designed heparinases derived from heparinase I and II and methods of sequencing therewith
    Patent number: 7560106
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: July 14, 2009
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
  • Compositions of and Methods of Using Oversulfated Glycosaminoglycans
    Publication number: 20090105463
    Abstract: The invention relates, in part, to compositions comprising glycosaminoglycans, fragments of glycosaminoglycans or glycosaminoglycan fractions. The compositions provided can be used in various methods of modulating FGF and/or VEGF activity. The method can be in vitro or in vivo methods. Therefore, the invention also relates, in part, to methods of treating a subject with the compositions provided.
    Type: Application
    Filed: March 29, 2006
    Publication date: April 23, 2009
    Applicant: Massachusetts Institute of Technology
    Inventors: David A. Berry, Kevin Pojasek, Dongfang Liu, Chi-Pong Kwan, Yiwei Qi, Ram Sasisekharan
  • MODIFIED HEPARINASE III AND METHODS OF SEQUENCING THEREWITH
    Publication number: 20090081635
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: October 29, 2008
    Publication date: March 26, 2009
    Applicant: Massachusetts Institute of Technology
    Inventors: DONGFANG LIU, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Heparinase III and methods of specifically cleaving therewith
    Patent number: 7455986
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis , etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: November 25, 2008
    Assignee: Massachusetts Institute of Technology, Inc.
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Methods and products related to evaluating the quality of a polysaccharide
    Patent number: 7399604
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: July 15, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Methods for preparing low molecular weight heparin with modified heparinase III
    Patent number: 7390633
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: June 24, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Testing cell cycle regulation effect of a compound using a hollow fibre cell implant
    Publication number: 20070172425
    Abstract: The invention includes an in vivo pharmacodynamic method for testing a compound for cell cycle regulation.
    Type: Application
    Filed: May 27, 2004
    Publication date: July 26, 2007
    Inventor: DongFang Liu
  • Methods and products related to evaluating the quality of a polysaccharide
    Publication number: 20070161073
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: November 30, 2006
    Publication date: July 12, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Rationally designed heparinases derived from heparinase II
    Publication number: 20070148158
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Application
    Filed: December 20, 2006
    Publication date: June 28, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
  • Methods and products related to producing low molecular weight heparin
    Publication number: 20070065921
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: September 8, 2006
    Publication date: March 22, 2007
    Applicant: Massachusetts Institute Of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Methods for preparing low molecular weight heparin with modified heparinase III
    Publication number: 20060182734
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: April 18, 2006
    Publication date: August 17, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Compositions of low molecular weight heparin produced with modified heparinase III
    Publication number: 20060183713
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: April 18, 2006
    Publication date: August 17, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Methods and products related to the analysis of polysaccarides
    Patent number: 7083937
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: August 1, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Rationally designed heparinases derived from heparinase I and II
    Patent number: 7056504
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: June 6, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
  • Rationally designed heparinases derived from heparinase I and II and methods of sequencing therewith
    Publication number: 20060105430
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Application
    Filed: July 27, 2005
    Publication date: May 18, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
  • Heparinase III and methods of specifically cleaving therewith
    Publication number: 20060067928
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis , etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: July 22, 2005
    Publication date: March 30, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Methods and products related to evaluating the quality of a polysaccharide
    Publication number: 20060024664
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: July 15, 2005
    Publication date: February 2, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi