Patents by Inventor Dong-Fang Shi

Dong-Fang Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic agonists of GPR131 and uses thereof
    Patent number: 9593109
    Abstract: The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: March 14, 2017
    Assignee: CYMABAY THERAPEUTICS, INC.
    Inventors: Jiangao Song, Phuongly Pham, Jingyuan Ma, Aaron Robert Novack, Imad Nashashibi, David W. G. Wone, Dong-Fang Shi, Xin Chen
  • N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
    Patent number: 8846675
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: September 30, 2014
    Assignee: Cymabay Therapeutics, Inc.
    Inventors: Jingyuan Ma, Christopher J. Rabbat, Jiangao Song, Xin Chen, Imad Nashashibi, Zuchun Zhao, Aaron Novack, Dong Fang Shi, Peng Cheng, Yan Zhu, Alison Murphy
  • GPR120 RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20140121246
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Application
    Filed: October 15, 2013
    Publication date: May 1, 2014
    Applicant: Metabolex, Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Christopher J. Rabbat, Jingyuan Ma, Aaron Novack, Imad Nashashibi, Xin Chen
  • Agonists of GPR131 and uses thereof
    Patent number: 8703776
    Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: April 22, 2014
    Assignee: Cymabay Therapeutics, Inc.
    Inventors: Aaron Robert Novack, Dong-Fang Shi, Jingyuan Ma, Imad Nashashibi, Phuongly Pham, Jiangao Song, David W. G. Wone, Xueyan Wang, Jeffrey D. Johnson, Brian Edward Lavan, Charles A. McWherter, Xin Chen
  • GPR120 receptor agonists and uses thereof
    Patent number: 8598374
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: December 3, 2013
    Assignee: Metabolex, Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Christopher J. Rabbat, Jingyuan Ma, Aaron Novack, Imad Fayek Nashashibi, Xin Chen, Phuongly Pham
  • GPR120 receptor agonists and uses thereof
    Patent number: 8476308
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: July 2, 2013
    Assignee: Metabolex, Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Jingyuan Ma, Aaron Novack, Phuongly Pham, Imad Fayek Nashashibi, Christopher J. Rabbat, Xin Chen
  • BICYCLIC AGONISTS OF GPR131 AND USES THEREOF
    Publication number: 20130059845
    Abstract: The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.
    Type: Application
    Filed: August 24, 2012
    Publication date: March 7, 2013
    Inventors: Jiangao SONG, Phuongly Pham, Jingyuan Ma, Aaron Robert Novack, Imad Nashashibi, David W. G. Wone, Dong-Fang Shi, Xin Chen
  • AGONISTS OF GPR131 AND USES THEREOF
    Publication number: 20130059856
    Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.
    Type: Application
    Filed: June 13, 2012
    Publication date: March 7, 2013
    Inventors: Aaron Robert Novack, Dong-Fang Shi, Jingyuan Ma, Imad Nashashibi, Phuongly Pham, Jiangao Song, David W. G. Wone, Xueyan Wang, Jeffrey D. Johnson, Brian Edward Lavan, Charles A. McWherter, Xin Chen
  • N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
    Publication number: 20120322804
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
    Type: Application
    Filed: May 3, 2012
    Publication date: December 20, 2012
    Inventors: Jingyuan Ma, Christopher J. Rabbat, Jiangao Song, Xin Chen, Imad Nashashibi, Zuchun Zhao, Aaron Novack, Dong Fang Shi, Peng Cheng, Yan Zhu, Alison Murphy
  • GPR120 receptor agonists and uses thereof
    Patent number: 8309600
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: November 13, 2012
    Assignee: Metabolex Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Jingyuan Ma, Aaron Novack, Phuongly Pham, Imad Fayek Nashashibi, Christopher J. Rabbat, Xin Chen
  • GPR120 receptor agonists and uses thereof
    Patent number: 8299117
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 30, 2012
    Assignee: Metabolex Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Jingyuan Ma, Aaron Novack, Phuongly Pham, Imad Fayek Nashashibi, Christopher J. Rabbat, Xin Chen
  • N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
    Patent number: 8183381
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: May 22, 2012
    Assignee: Metabolex Inc.
    Inventors: Jingyuan Ma, Christopher J. Rabbat, Jiangao Song, Xin Chen, Imad Nashashibi, Zuchun Zhao, Aaron Novack, Dong Fang Shi, Peng Cheng, Yan Zhu, Alison Murphy
  • GPR120 RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20110313003
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Application
    Filed: June 16, 2010
    Publication date: December 22, 2011
    Inventors: Dong Fang Shi, Jiangao Song, Jingyuan Ma, Aaron Novack, Phuongly Pham, Imad Fayek Nashashibi, Christopher J. Rabbat, Xin Chen
  • ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20100216827
    Abstract: Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Application
    Filed: October 20, 2009
    Publication date: August 26, 2010
    Inventors: Jingyuan Ma, Aaron Novack, Imad Nashashibi, Phuongly Pham, Christopher J. Rabbat, Jiangao Song, Dong Fang Shi, Zuchun Zhao, Yun-Jung Choi, Xin Chen
  • GPR120 RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20100190831
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Application
    Filed: December 17, 2009
    Publication date: July 29, 2010
    Inventors: Dong Fang Shi, Jiangao Song, Jingyuan Ma, Aaron Novack, Phuongly Pham, Imad Fayek Nashashibi, Christopher J. Rabbat, Xin Chen
  • N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
    Publication number: 20090137590
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
    Type: Application
    Filed: July 10, 2008
    Publication date: May 28, 2009
    Inventors: Jingyuan Ma, Christopher J. Rabbat, Jiangao Song, Xin Chen, Imad Nashashibi, Zuchun Zhao, Aaron Novack, Dong Fang Shi, Peng Cheng, Yan Zhu, Alison Murphy
  • Bicyclic heteroaryl derivatives
    Patent number: 7511145
    Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: March 31, 2009
    Assignee: Genelabs Technologies, Inc.
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ronald Conrad Griffith, Janos Botyanszki, Mikail Hakan Gezginci, Joshua Michael Gralapp, Dong-Fang Shi, Sebastian Johannes Reinhard Liehr
  • BICYCLIC HETEROARYL DERIVATIVES
    Publication number: 20090081165
    Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
    Type: Application
    Filed: October 30, 2008
    Publication date: March 26, 2009
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ronald Conrad Griffith, Janos Botyanszki, Mikail Hakan Gezginci, Joshua Michael Gralapp, Dong-Fang Shi, Sebastian Johannes Reinhard Liehr
  • NITROGEN-CONTAINING HETEROARYL DERIVATIVES
    Publication number: 20080247992
    Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
    Type: Application
    Filed: October 24, 2007
    Publication date: October 9, 2008
    Inventors: Christopher D. Roberts, Dong-Fang Shi, Ronald C. Griffith
  • POLYCYCLIC VIRAL INHIBITORS
    Publication number: 20080045498
    Abstract: Disclosed are compounds and compositions of Formula (A) and their uses for treating Flaviviridae family virus infections.
    Type: Application
    Filed: July 19, 2007
    Publication date: February 21, 2008
    Inventors: Ronald Griffith, Christopher Roberts, Franz Schmitz, Janos Botyanszki, Rachel Marek, Dong-Fang Shi, Son Pham