Patents by Inventor Donghao Chen
Donghao Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141537Abstract: The present disclosure provides a superhydrophobic and self-cleaning anticoagulant composite coating material and a preparation method and use thereof, and relates to the technical field of biomedical materials. In the coating material provided by the present disclosure, a titanium dioxide nanotube-based structure increases microscopic roughness of a surface of a titanium-based metal substrate, and a hydrophobic modification layer reduces surface energy of the material. The rough structure and the hydrophobic modification layer have a synergistic effect to construct a superhydrophobic surface, making the surface of the material have self-cleaning characteristics and low adhesion. Air can be retained on the surface of the material to form an air layer, thereby reducing the contact area between the material and bacteria and platelets in the blood, and inhibiting adhesion of the bacteria, platelets, and plasma proteins to the material.Type: ApplicationFiled: November 8, 2022Publication date: May 2, 2024Applicant: Anhui Medical UniversityInventors: Shunli ZHENG, Qin RAO, Ling WENG, Jinshuang ZHANG, Donghao LIU, Quanli LI, Ying CAO, Jialong CHEN, Xiangyang LI, Hua QIU, Shengzhuo ZHANG, Daojun SHEN
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Publication number: 20150342878Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: December 22, 2014Publication date: December 3, 2015Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey D. Mintzes, Jue Wang, Donghao Chen
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Publication number: 20150104515Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: May 15, 2014Publication date: April 16, 2015Applicant: Massachusetts Institute of TechnologyInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey D. Mintzes, Jue Wang, Donghao Chen
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Publication number: 20120107241Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: August 29, 2011Publication date: May 3, 2012Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20110077284Abstract: A dry powder formulation for delivery to a mammal by inhalation, the formulation comprising particles comprising a lipid, a carrier, and one or more double-stranded siRNA molecules or dicer-active precursors targeted to influenza virus A method for treating or preventing influenza in a mammal comprising administering a therapeutically-effective amount of a dry powder formulation.Type: ApplicationFiled: October 13, 2010Publication date: March 31, 2011Applicant: MARINA BIOTECH, INC.Inventors: Luis Brito, Donghao Chen, Qing Ge, Douglas A. Treco
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Patent number: 7628977Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: GrantFiled: April 18, 2003Date of Patent: December 8, 2009Assignees: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Patent number: 7469488Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: GrantFiled: October 29, 2004Date of Patent: December 30, 2008Assignees: Alkermes, Inc., The Penn State Research FoundationInventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20080253971Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: April 18, 2003Publication date: October 16, 2008Applicants: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David Edwards, Robert Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20080227690Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.Type: ApplicationFiled: September 24, 2007Publication date: September 18, 2008Inventors: JENNIFER L. SCHMITKE, DONGHAO CHEN, RICHARD P. BATYCKY, DAVID A. EDWARDS, JEFFREY S. HRKACH
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Publication number: 20080226730Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.Type: ApplicationFiled: September 24, 2007Publication date: September 18, 2008Inventors: Jennifer L. Schmitke, Donghao Chen, Richard P. Batycky, David A. Edwards, Jeffrey S. Hrkach
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Publication number: 20070172430Abstract: A dry powder formulation for mucosal, intranasal, inhalation or pulmonary delivery which may include one or more siRNAs or dicer-active precursors thereof targeted to a transcript involved in infection by, or replication or production of an influenza virus.Type: ApplicationFiled: January 15, 2007Publication date: July 26, 2007Inventors: Luis Brito, Donghao Chen, Qing Ge, Doug Treco
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Publication number: 20070014738Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: September 20, 2006Publication date: January 18, 2007Inventors: David Edwards, Robert Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Patent number: 7052678Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles.Type: GrantFiled: March 7, 2002Date of Patent: May 30, 2006Assignees: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: Rita Vanbever, Robert S. Langer, David A. Edwards, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20060105051Abstract: Methods of making porous particles by using carbon dioxide assisted nebulization (CAN) technology in combination with spray drying technologies are disclosed. As the mixture of carbon dioxide (CO2) and the solvent with drug matrix is expanded through the nebulizer to atmospheric conditions, the resulting aerosol contains fine micro-bubbles and/or micro-droplets that contains dissolved CO2 which is co-currently fed into a spray drying chamber.Type: ApplicationFiled: October 27, 2005Publication date: May 18, 2006Inventors: Blair Jackson, David Bennett, Donghao Chen, Michael Lipp, Purav Dave
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Publication number: 20050058607Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: ApplicationFiled: October 29, 2004Publication date: March 17, 2005Applicants: Avanced Inhalation Research, Inc., The Penn State Research FoundationInventors: Donghao Chen, Richard Batycky, LIoyd Johnson, Jeffrey Mintzes
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Patent number: 6848197Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: GrantFiled: April 18, 2001Date of Patent: February 1, 2005Assignees: Advanced Inhalation Research, Inc., The Penn State Research Foundation, Inc.Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20040062718Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: April 18, 2003Publication date: April 1, 2004Applicants: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Patent number: 6652837Abstract: Particles incorporating a surfactant and/or a hydrophilic or hydrophobic complex of a positively or negatively charged therapeutic agent and a charged molecule of opposite charge for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m, which together yield an aerodynamic diameter of the particles of between approximately one and three microns. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymers thereof. Alternatively, the particles may be formed solely of a therapeutic or diagnostic agent and a surfactant.Type: GrantFiled: September 13, 1999Date of Patent: November 25, 2003Assignees: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20030125236Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.Type: ApplicationFiled: June 24, 2002Publication date: July 3, 2003Applicant: Advenced Inhalation Research, Inc.Inventors: Jennifer L. Schmitke, Donghao Chen, Richard P. Batycky, David A. Edwards
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Publication number: 20030068277Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles.Type: ApplicationFiled: March 7, 2002Publication date: April 10, 2003Applicant: Massachusetts Institute of TechnologyInventors: Rita Vanbever, Robert S. Langer, David A. Edwards, Jeffrey Mintzes, Jue Wang, Donghao Chen