Patents by Inventor Donghao Chen

Donghao Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150342878
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
    Type: Application
    Filed: December 22, 2014
    Publication date: December 3, 2015
    Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey D. Mintzes, Jue Wang, Donghao Chen
  • Publication number: 20150104515
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
    Type: Application
    Filed: May 15, 2014
    Publication date: April 16, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey D. Mintzes, Jue Wang, Donghao Chen
  • Publication number: 20120107241
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
    Type: Application
    Filed: August 29, 2011
    Publication date: May 3, 2012
    Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Publication number: 20110077284
    Abstract: A dry powder formulation for delivery to a mammal by inhalation, the formulation comprising particles comprising a lipid, a carrier, and one or more double-stranded siRNA molecules or dicer-active precursors targeted to influenza virus A method for treating or preventing influenza in a mammal comprising administering a therapeutically-effective amount of a dry powder formulation.
    Type: Application
    Filed: October 13, 2010
    Publication date: March 31, 2011
    Applicant: MARINA BIOTECH, INC.
    Inventors: Luis Brito, Donghao Chen, Qing Ge, Douglas A. Treco
  • Patent number: 7628977
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: December 8, 2009
    Assignees: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Patent number: 7469488
    Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: December 30, 2008
    Assignees: Alkermes, Inc., The Penn State Research Foundation
    Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
  • Publication number: 20080253971
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
    Type: Application
    Filed: April 18, 2003
    Publication date: October 16, 2008
    Applicants: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: David Edwards, Robert Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Publication number: 20080227690
    Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.
    Type: Application
    Filed: September 24, 2007
    Publication date: September 18, 2008
    Inventors: JENNIFER L. SCHMITKE, DONGHAO CHEN, RICHARD P. BATYCKY, DAVID A. EDWARDS, JEFFREY S. HRKACH
  • Publication number: 20080226730
    Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.
    Type: Application
    Filed: September 24, 2007
    Publication date: September 18, 2008
    Inventors: Jennifer L. Schmitke, Donghao Chen, Richard P. Batycky, David A. Edwards, Jeffrey S. Hrkach
  • Publication number: 20070172430
    Abstract: A dry powder formulation for mucosal, intranasal, inhalation or pulmonary delivery which may include one or more siRNAs or dicer-active precursors thereof targeted to a transcript involved in infection by, or replication or production of an influenza virus.
    Type: Application
    Filed: January 15, 2007
    Publication date: July 26, 2007
    Inventors: Luis Brito, Donghao Chen, Qing Ge, Doug Treco
  • Publication number: 20070014738
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
    Type: Application
    Filed: September 20, 2006
    Publication date: January 18, 2007
    Inventors: David Edwards, Robert Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Patent number: 7052678
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: May 30, 2006
    Assignees: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: Rita Vanbever, Robert S. Langer, David A. Edwards, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Publication number: 20060105051
    Abstract: Methods of making porous particles by using carbon dioxide assisted nebulization (CAN) technology in combination with spray drying technologies are disclosed. As the mixture of carbon dioxide (CO2) and the solvent with drug matrix is expanded through the nebulizer to atmospheric conditions, the resulting aerosol contains fine micro-bubbles and/or micro-droplets that contains dissolved CO2 which is co-currently fed into a spray drying chamber.
    Type: Application
    Filed: October 27, 2005
    Publication date: May 18, 2006
    Inventors: Blair Jackson, David Bennett, Donghao Chen, Michael Lipp, Purav Dave
  • Publication number: 20050058607
    Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.
    Type: Application
    Filed: October 29, 2004
    Publication date: March 17, 2005
    Applicants: Avanced Inhalation Research, Inc., The Penn State Research Foundation
    Inventors: Donghao Chen, Richard Batycky, LIoyd Johnson, Jeffrey Mintzes
  • Patent number: 6848197
    Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: February 1, 2005
    Assignees: Advanced Inhalation Research, Inc., The Penn State Research Foundation, Inc.
    Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
  • Publication number: 20040062718
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
    Type: Application
    Filed: April 18, 2003
    Publication date: April 1, 2004
    Applicants: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Patent number: 6652837
    Abstract: Particles incorporating a surfactant and/or a hydrophilic or hydrophobic complex of a positively or negatively charged therapeutic agent and a charged molecule of opposite charge for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m, which together yield an aerodynamic diameter of the particles of between approximately one and three microns. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymers thereof. Alternatively, the particles may be formed solely of a therapeutic or diagnostic agent and a surfactant.
    Type: Grant
    Filed: September 13, 1999
    Date of Patent: November 25, 2003
    Assignees: Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Publication number: 20030125236
    Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.
    Type: Application
    Filed: June 24, 2002
    Publication date: July 3, 2003
    Applicant: Advenced Inhalation Research, Inc.
    Inventors: Jennifer L. Schmitke, Donghao Chen, Richard P. Batycky, David A. Edwards
  • Publication number: 20030068277
    Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles.
    Type: Application
    Filed: March 7, 2002
    Publication date: April 10, 2003
    Applicant: Massachusetts Institute of Technology
    Inventors: Rita Vanbever, Robert S. Langer, David A. Edwards, Jeffrey Mintzes, Jue Wang, Donghao Chen
  • Publication number: 20030017113
    Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.
    Type: Application
    Filed: April 18, 2001
    Publication date: January 23, 2003
    Applicant: Advanced Inhalation Research, Inc.
    Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes