Abstract: A refrigerator may include: a first tray forming a part of ice-making cells; a second tray forming the other part of the ice-making cells; a heater for supplying heat to the ice making cells; a cooler for supplying cold to a storage compartment; and a control unit for controlling the heater and the cooler. The operation modes of the refrigerator include a first mode and a second mode. The control unit may control so that either or both of the amounts of cooling by the cooler and the amount of heating by the heater vary in the first mode and the second mode.

Abstract: A refrigerator may include a first tray assembly forming a part of an ice making cell, a second tray assembly forming another part of the ice making cell, a heater provided adjacent to at least one of the first or second tray assemblies, a driver connected to the second tray assembly, and a control unit to control the heater and the driver. The driving unit includes a cam capable of being connected to the second tray assembly, and a path in which a lever moves is formed inside the cam.

Abstract: The refrigerator may comprise: a first tray assembly forming a part of ice-making cells; and a second tray assembly forming the other part of the ice-making cells. In order that ice can be produced in the direction of ice-making cells formed by any One of the first and second tray assemblies to ice-making cells formed by the other tray assembly, following the start of an ice-making process, the one tray assembly comprises a first part, and the first part comprises: a first surface forming a part of the ice-making cells; and a first deformation-resistant reinforcement part extending from the first surface in the vertical direction away from a heater.

Abstract: A refrigerator includes a first tray assembly defining a portion of an ice making cell, a second tray assembly defining another portion of the ice making cell, a heater disposed adjacent to at least one of the first and second tray assemblies, and a controller configured to control the heater. The refrigerator further includes a pusher having a first edge pressing the ice or at least one of the first and second tray assemblies to separate the ice from the tray assemblies, a bar extending from the first edge, and a second edge disposed at the end of the bar. The second tray assembly includes a first coupling part connected to the pusher and a second coupling part connected to the driver. The controller moves at least one of the pusher and the second tray assembly to change a relative position between the pusher and the second tray assembly.

Abstract: The present invention relates to a refrigerator. A refrigerator according to the present invention may comprises a first tray assembly forming one part of ice-making cells, and a second tray assembly forming the other part of same. Following the start of ice making process, so that ice can be produced in the direction of ice-making cells formed by any one tray assembly, from among the first and second tray assemblies, to the ice-making cells formed by the other tray assembly, the other tray assembly comprises a first surface forming a part of the ice-making cells, and a second surface extending from the first surface and supported by at least one surface of the one assembly.

Abstract: A refrigerator of the present disclosure can include an ice making cell, a heater configured to supply heat to the ice making cell during an ice making process, and a controller configured to control the heater. The process for controlling the heater includes a basic heating process and an additional heating process that is performed after the basic heating process. In the basic heating process, the controller performs control so that a heating amount of the heater varies according to a mass per unit height of water in the ice making cell. In at least partial section of the additional heating process, the controller controls the heater to operate with a heating amount that is equal to or less than a heating amount of the heater in the basic heating process.

Abstract: A refrigerator comprises: a storage chamber, a cooler, a first tray, a second tray, the first portion and the second portion being configured to define a space formed by the cell to receive a liquid to be phase-changed to form ice, a heater provided adjacent to at least one of the first tray or the second tray; and a controller configured to: operate the heater while the ice is being formed so that gas bubbles dissolved in the liquid within the cell move from a portion of space where the liquid that has phase-changed into the ice to another portion of the space where the liquid is in a fluid state, and when a defrosting start condition is satisfied while the ice is being formed in the space of the cell, perform a defrosting process and reduce an amount of cold supplied by the cooler.

Abstract: The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bi-specific antibody for the prevention, treatment and/or diagnosis of synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

Abstract: An ice maker comprises: a first tray forming a part of an ice-making cell; a second tray forming another part of the ice-making cell; and a heater which is disposed so as to be adjacent to the first or the second tray, wherein the heater operates during a period when cold air is supplied to the first tray and the second tray and ice making takes place, and supplies heat to the first tray and/or the second tray.

Abstract: The refrigerator may comprise: a first tray assembly forming a part of ice-making cells; and a second tray assembly forming the other part of the ice-making cells. In order that ice can be produced in the direction of ice-making cells formed by any One of the first and second tray assemblies to ice-making cells formed by the other tray assembly, following the start of an ice-making process, the one tray assembly comprises a first part, and the first part comprises: a first surface forming a part of the ice-making cells; and a first deformation-resistant reinforcement part extending from the first surface in the vertical direction away from a heater.

Abstract: A method for controlling a refrigerator of the present invention includes turning on the heater when ice making is completed; moving the second tray to a standby position in a forward direction when the movement condition of the second tray is satisfied; turning off the heater when a turn-off condition of the heater is satisfied after the second tray moves to the standby position in the forward direction; determining whether the heater is turned off and a predetermined time has elapsed; and moving the second tray to the ice separation position in the forward direction when it is determined that the predetermined time has elapsed.

Abstract: A refrigerator may include: a storage chamber, a first ice-maker, a second ice-maker, a cooler for supplying the cold to the storage chamber and the ice-making chamber, an ice bin for storing ice generated by the second ice-maker, a water supply unit for supplying water to the ice-making cell, a heater for supplying heat to the ice-making cell, and a controller for controlling the heater. The controller may increase the heating amount of the heater when the heat transfer amount between the cold in the storage chamber and the water in the ice-making cell is increased, and decreases the heating amount of the heater when the heat transfer amount between the cold in the storage chamber and the water in the ice-making cell is reduced.

Abstract: A refrigerator includes a storage chamber, a cold air supply which supplies cold air to the storage chamber, a first tray which forms a part of an ice making cell that is a space where water is phase-changed into ice by the cold air, a second tray which forms another part of the ice making cell and which may come into contact with the first tray during an ice making process and may be separated from the first tray during an ice transfer process, a heater adjacent to at least one of the first tray or the second tray, a sensor which determines the position of the second tray in a movement process of the second tray, and a control unit which controls the heater.

Abstract: A refrigerator of the present invention may comprise: a first tray assembly forming a part of an ice making cell; and a second tray assembly forming the other part of the ice making cell. The first tray assembly includes a first tray, and the second tray assembly includes a second tray. The second tray includes a first portion forming at least a portion of the ice making cell, and a second portion extending from a predetermined point of the first portion. The second portion includes a first extension part extending from a first point of the first portion and a second extension part extending from a second point of the first portion, wherein the length of the second extension part in the horizontal direction is formed longer than the length of the first extension part.

Abstract: Provided is a refrigerator. The refrigerator may include a first tray assembly defining a portion of an ice making cell and a second tray assembly defining another portion of the ice making cell. The one tray assembly of the first and second tray assemblies may include a first portion that defines at least a portion of the ice making cell and a second portion extending from a predetermined point of the first portion.

Abstract: The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.

Abstract: The present invention relates to an anti-alpha-synuclein antibody preferentially recognizing alpha-synuclein aggregates and a use of detection, diagnosis, and/or treatment or prevention of various diseases caused by accumulation of alpha-synuclein aggregates, or their related symptom diseases by using the anti-alpha-synuclein antibody.

Abstract: The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.

Abstract: The present invention relates to a novel compound comprising a galactose trigger moiety and cyclopropabenzindole (CBI), and an antibody-drug conjugate prepared by using same.

Abstract: Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.