Abstract: The present disclosure provides a solid pharmaceutical composition, which comprises a compound represented by formula 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the compound represented by formula 1 or a pharmaceutically acceptable salt thereof comprises from about 30% to about 80% of the total weight of the solid pharmaceutical composition.

Abstract: A multi-laser scanning control method includes: dividing, along a blowing direction, each forming area corresponding to one of a plurality of lasers into a plurality of logical sub-regions; planning a scanning order for the plurality of logical sub-regions within each forming area according to a predetermined scanning order determination rule; and controlling each laser to sequentially scan the plurality of logical sub-regions within its corresponding forming area according to the scanning order until scanning of the forming areas corresponding to the plurality of lasers is completed.

Abstract: Provided are a method for grout injection repair and water retention in a goaf, including: determining extraction information on the goaf and a coal seam, forming a barrier wall through performing a first grouting operation at a side of the goaf near the coal seam based on the extraction information, performing a second grouting operation to complete a grout injection repair from outside to inside in the goaf based on the extraction information. The first grouting pressure of the first grouting operation is less than the second grouting pressure of the second grouting operation.

Abstract: A method for testing and evaluating lateral stiffness of small box girder bridges is provided. The method includes the following steps: a deflection sensor collects a deflection value of a measuring point based on a loading process of a loading vehicle; based on the deflection value of the measuring point and an information matrix of the loading vehicle, an influence line of longitudinal bridge deflection of each measuring point is obtained; based on the influence line of longitudinal bridge deflection, the influence line of lateral bridge deflection of small box girder bridge is obtained by interpolation method; and based on the influence line of lateral deflection of small box girder bridge, a stiffness evaluation result is obtained.

Abstract: Disclosed are a coal mining system and a coal mining method. The coal mining system includes: a mechanical coal breaking module, an air lift reverse circulation module, a jet coal breaking module, and a coal-air-water separation module. The mechanical coal breaking module includes: a drill pipe rotating device, a drill pipe, and a reamer bit, sequentially connected to perform rotary cutting, drilling and slotting operations on a coal seam in a borehole. The air lift reverse circulation module includes: an air compressor and a dual-wall drill pipe. The air compressor is configured to transport a coal-air-water mixture through an inner pipeline of the dual-wall drill pipe to the coal-air-water separation module. The jet coal breaking module includes: the drill pipe rotating device, a fracturing truck, the drill pipe, and a jet tool string, sequentially connected to mine the coal seam.

Abstract: Disclosed are a coal mining system and a coal mining method. The coal mining system includes: a mechanical coal breaking module, an air lift reverse circulation module, a jet coal breaking module, and a coal-air-water separation module. The mechanical coal breaking module includes: a drill pipe rotating device, a drill pipe, and a reamer bit, sequentially connected to perform rotary cutting, drilling and slotting operations on a coal seam in a borehole. The air lift reverse circulation module includes: an air compressor and a dual-wall drill pipe. The air compressor is configured to transport a coal-air-water mixture through an inner pipeline of the dual-wall drill pipe to the coal-air-water separation module. The jet coal breaking module includes: the drill pipe rotating device, a fracturing truck, the drill pipe, and a jet tool string, sequentially connected to mine the coal seam.

Abstract: Disclosed are an integrated mining method and an integrated mining system of coal breaking, coal extraction and water circulation in a U-well. The integrated mining system includes a first ground facility unit, a second ground facility unit, a jet unit and an extraction unit. The first ground facility unit is configured to transport jet fluid to the jet unit. The jet unit is configured to break a coal seam in a sub-segment to obtain broken cinders. The extraction unit is configured to extract a coal-water mixture. The second ground facility unit is configured to receive the coal-water mixture. In response to determining that an extraction of the sub-segment is complete, the jet unit and the extraction unit is configured to move to a next sub-segment using powers provided by the first ground facility unit and the second ground facility unit.

Abstract: A coal and coalbed methane mining system based on ground drilling includes: a drilling component, a coal mining drill bit and a ground facility group. The coal mining drill bit is set at a predetermined end of a directional borehole in a coal seam, connected to the drilling component through a connecting pipeline. The ground facility group is connected to the drilling component, to provide coal cutting slurry for the coal mining drill bit, receive reflux slurry carrying coal and coalbed methane, and precipitate and separate the reflux slurry carrying the coal and the coalbed methane. A coal and coalbed methane mining method based on ground drilling and related devices are also disclosed.

Abstract: The disclosure relates to a cryoablation catheter and a cryoablation system. The cryoablation catheter comprises a catheter body and a freezing unit. The catheter body comprises a cold-source fluid input lumen and a cold-source fluid output lumen, both extending in an axial direction of the catheter body, and the freezing unit is arranged at a distal portion of the catheter body, and comprises a first balloon in fluid communication with the cold-source fluid input lumen and the cold-source fluid output lumen, and a second balloon arranged external to the first balloon with the length of the first balloon being less than the length of the second balloon. When the first balloon and the second balloon are dilated, a cavity is formed between the first balloon and the second balloon, to prevent the energy transfer in a space of the freezing unit corresponding to the cavity.

Abstract: The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.

Abstract: Provided are a fluid circulation system and a method for operating same, a computer-readable medium, and a controller. The fluid circulation system comprises: a scroll expander, and an external fluid circulation path, which comprises a high-pressure fluid pipe and a low-pressure fluid pipe. The operation method comprises the following steps: before fluid is supplied to the scroll expander, making the fluid pressure in the high-pressure fluid pipe higher than the fluid pressure in the low-pressure fluid pipe by a pre-determined pressure difference; and after the pre-determined pressure difference is realized, starting the scroll expander and supplying fluid to the scroll expander. According to the present disclosure, the technical problem of a scroll expander being unable to be normally started and work can be avoided, and the invention is simple, practical, convenient, and easily implemented.

Abstract: Disclosed are a fluid pumping device and a horizontal compressor. The fluid pumping device comprises a pump structure in the form of an internal-meshing gear pump and is provided with first and second pump members, a pump housing structure for accommodating the pump structure, and at least two suction paths and/or at least two discharge paths. Suction and compression cavities are defined between the first and second pump members; the at least two suction paths are configured to rotate with the pump structure, and a fluid can be sucked into the suction cavity via the at least two suction paths respectively; and the at least two discharge paths are configured to rotate with the pump structure, and the compressed fluid can be discharged from the fluid pumping device via the discharge paths respectively. The fluid pumping device is assembled in the horizontal compressor.

Abstract: The present disclosure application relates to a construction method of a yeast display library (YSD), specifically to a construct for a yeast display library, an expression vector, a host cell and a construction method and use thereof. The yeast display library provided by the present application has high transformation efficiency and rich diversity.

Abstract: An expander and a fluid circulation system comprising same are disclosed. The expander comprises a housing, an expansion mechanism, an exhaust pipe, an oil sump and a lubricant discharge channel. The expansion mechanism is provided in the housing to expand a high-pressure fluid into a low-pressure fluid. The exhaust pipe discharges the low-pressure fluid out of the expander and comprises an end portion assembled in a first opening of the housing and provided with an exhaust port; the low-pressure fluid enters the exhaust pipe via the exhaust port. The oil sump stores a lubricant in the housing. The lubricant discharge channel discharges the lubricant in the oil sump into the exhaust pipe and/or an external system pipeline and comprises an inlet end having an inlet located at a predetermined oil level of the oil sump and an outlet end having an outlet.

Abstract: Provided are a fluid circulation system and a method for operating same, a computer-readable medium, and a controller. The fluid circulation system comprises: a scroll expander, and an external fluid circulation path, which comprises a high-pressure fluid pipe and a low-pressure fluid pipe. The operation method comprises the following steps: before fluid is supplied to the scroll expander, making the fluid pressure in the high-pressure fluid pipe higher than the fluid pressure in the low-pressure fluid pipe by a pre-determined pressure difference; and after the pre-determined pressure difference is realized, starting the scroll expander and supplying fluid to the scroll expander. According to the present disclosure, the technical problem of a scroll expander being unable to be normally started and work can be avoided, and the invention is simple, practical, convenient, and easily implemented.

Abstract: A scroll expander, comprising: a housing; and an expansion mechanism provided in the housing. A back pressure chamber in fluid communication with a medium pressure chamber is provided in the expansion mechanism and is provided with at least one passage in fluid communication from the back pressure chamber to a low pressure region; the passage is configured such that: the passage is opened when the pressure in the back pressure chamber is lower than the pressure of the low pressure region, and is closed when the pressure in the back pressure chamber is higher than or equal to the pressure of the low pressure region. The scroll expander can avoid the problem of being unable to be started and to operate normally; and the scroll expander is simple in structure, easy to process and manufacture, and high in cost effectiveness.

Abstract: The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.

Abstract: The present disclosure application relates to a construction method of a yeast display library (YSD), specifically to a construct for a yeast display library, an expression vector, a host cell and a construction method and use thereof. The yeast display library provided by the present application has high transformation efficiency and rich diversity.

Abstract: A scroll expander, comprising: a housing; and an expansion mechanism provided in the housing. A back pressure chamber in fluid communication with a medium pressure chamber is provided in the expansion mechanism and is provided with at least one passage in fluid communication from the back pressure chamber to a low pressure region; the passage is configured such that: the passage is opened when the pressure in the back pressure chamber is lower than the pressure of the low pressure region, and is closed when the pressure in the back pressure chamber is higher than or equal to the pressure of the low pressure region. The scroll expander can avoid the problem of being unable to be started and to operate normally; and the scroll expander is simple in structure, easy to process and manufacture, and high in cost effectiveness.

Abstract: The present invention relates to a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, a method for inhibiting indoleamine 2,3-dioxygenase, and its use in medicine.