Abstract: A cyclonic separation device and a vacuum cleaner including the cyclonic separation device are disclosed. The cyclonic separation device includes a housing and a cyclonic separation device. The cyclonic separation device is provided in the housing to allow dirt in a dust-containing airflow to be separated. The cyclonic separation device includes a first-stage cyclone separator and second-stage cyclone separators located downstream of the first-stage cyclone separator in a flow direction of the airflow. The second-stage cyclone separators surround the first-stage cyclone separator. The first-stage cyclone separator includes an air guide channel and a first-stage cyclone channel surrounding a part of the air guide channel. The dust-containing airflow enters, from the air guide channel, the first-stage cyclone channel for cyclonic separation and then enters the second-stage cyclone separators again through the air guide channel.