Publication number: 20230142654
Abstract: The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient.
Type:
Application
Filed:
January 15, 2021
Publication date:
May 11, 2023
Inventors:
Chun Young IM, Sang Hyun MIN, Ji Hoon YU, Eun Bi KO, So Young KIM, Seungyeon LEE, Dong Kyu CHOI, Heejin LEE, Ga Young PARK, Doohyun LEE, Eunmi HONG, Hui-Jeon JEON, Young-Hoon PARK, Ye Ri HAN, Nam Hui KIM, Jun Woo KIM, Bae Jun OH, Jeong-Eun PARK, Chang Hoon SEO, Minsoo SONG, Seonggu RO, Dongkyu SHIN
Patent number: 10870647
Abstract: The present invention relates to a novel imidazopyridine derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof and a pharmaceutically acceptable salt thereof can effectively inhibit cancer-related kinases, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer.
Type:
Grant
Filed:
June 20, 2017
Date of Patent:
December 22, 2020
Assignee:
DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION
Inventors:
Hwan Geun Choi, Jung Beom Son, Shinae Kim, Seungyeon Lee, Eunhwa Ko, Joongheui Cho, Seock Yong Kang, So Young Kim, Jin-Hee Park, Yi Kyung Ko, Hee Yoon Ryu, Nam Doo Kim, Hyunkyoung Kim, Younho Lee, Sun-Hwa Lee, Dayea Kim, Sun Joo Lee, Seongho Hong, Sang Hyun Min, Sungwoo Lee, Dong Kyu Choi, Jae Hyun Bae, Eunmi Hong, Tae-Ho Jang, Jaeyoung Song, Sangbum Kim, Suk Kyoon Yoon