Patents by Inventor Dongliang Guan

Dongliang Guan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine
    Publication number: 20240018130
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Application
    Filed: September 14, 2023
    Publication date: January 18, 2024
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Pyrimidine derivative, method for preparing same and use thereof in medicine
    Patent number: 11827625
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: November 28, 2023
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof
    Patent number: 11142531
    Abstract: The present invention relates to a cyano-substituted heteroarylpyrimidinone derivative represented by formula (I), a preparation method therefor and a use thereof as a therapeutic agent, in particular a use as an acetyl-CoA carboxylase (ACC) inhibitor, and the definition of each substituent in formula (I) is the same as the definition in the description.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: October 12, 2021
    Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    Inventors: Hejun Lv, Dongliang Guan, Mingxiao Chen, Jinglu Wang, Lin Qian
  • Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine
    Publication number: 20210221797
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Application
    Filed: March 31, 2021
    Publication date: July 22, 2021
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Pyrimidine derivative, method for preparing same and use thereof in medicine
    Patent number: 11001572
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: May 11, 2021
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Vancomycin derivative, preparation method, pharmaceutical composition and use thereof
    Patent number: 10961278
    Abstract: Provided are a class of vancomycin derivatives with a structure as shown in the general formula below and pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition containing the compound thereof, and the use of these compounds in preparing drugs for treating and/or preventing bacterial infection diseases, in particular drugs for treating infection diseases caused by Gram-positive bacteria.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: March 30, 2021
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Wei Huang, Lefu Lan, Lun Xiong, Dongliang Guan, Feifei Chen, Iiyun Yang
  • Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine
    Publication number: 20200207745
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Application
    Filed: February 25, 2020
    Publication date: July 2, 2020
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • Pyrimidine derivative, method for preparing same and use thereof in medicine
    Patent number: 10654836
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 19, 2020
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • CYANO SUBSTITUTED HETEROARYLPYRIMIDINONE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
    Publication number: 20200102322
    Abstract: The present invention relates to a cyano-substituted heteroarylpyrimidinone derivative represented by formula (I), a preparation method therefor and a use thereof as a therapeutic agent, in particular a use as an acetyl-CoA carboxylase (ACC) inhibitor, and the definition of each substituent in formula (I) is the same as the definition in the description.
    Type: Application
    Filed: March 23, 2018
    Publication date: April 2, 2020
    Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    Inventors: Hejun LV, Dongliang GUAN, Mingxiao CHEN, Jinglu WANG, Lin QIAN
  • Acrylic acid derivative, preparation method and use in medicine thereof
    Patent number: 10519148
    Abstract: The present invention relates to an acrylic acid derivative as shown in general formula (I), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, the preparation method thereof, a pharmaceutical composition containing same, and the use thereof as therapeutic agents, in particular as selective estrogen receptor degraders (SERD), wherein the substituents of general formula (I) are the same as those defined in the description.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: December 31, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Dongliang Guan, Shouyi Sheng, Hua Bai
  • Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine
    Publication number: 20190161476
    Abstract: The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
    Type: Application
    Filed: May 19, 2017
    Publication date: May 30, 2019
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Jun Gou, Weifeng Zhao, Zhongli Wang, Long Ling, Yutao Ma
  • VANCOMYCIN DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Publication number: 20190153036
    Abstract: Provided are a class of vancomycin derivatives with a structure as shown in the general formula below and pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition containing the compound thereof, and the use of these compounds in preparing drugs for treating and/or preventing bacterial infection diseases, in particular drugs for treating infection diseases caused by Gram-positive bacteria.
    Type: Application
    Filed: April 26, 2017
    Publication date: May 23, 2019
    Inventors: Wei HUANG, Lefu LAN, Lun XIONG, Dongliang GUAN, Feifei CHEN, liyun YANG
  • Substituted pyrazoles as inhibitors of fibroblast growth factor receptor
    Patent number: 10214515
    Abstract: An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: February 26, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Xing Yan, Shuai Miao, Songsong Zhu
  • ACRYLIC ACID DERIVATIVE, PREPARATION METHOD AND USE IN MEDICINE THEREOF
    Publication number: 20180291019
    Abstract: The present invention relates to an acrylic acid derivative as shown in general formula (I), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, the preparation method thereof, a pharmaceutical composition containing same, and the use thereof as therapeutic agents, in particular as selective estrogen receptor degraders (SERD), wherein the substituents of general formula (I) are the same as those defined in the description.
    Type: Application
    Filed: October 11, 2016
    Publication date: October 11, 2018
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Dongliang Guan, Shouyi Sheng, Hua Bai
  • INDOLE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE THEREOF IN PHARMACEUTICAL DRUG
    Publication number: 20180194751
    Abstract: An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.
    Type: Application
    Filed: August 19, 2016
    Publication date: July 12, 2018
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Lei Chen, Dongliang Guan, Hua Bai, Xing Yan, Shuai Miao, Songsong Zhu
  • C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof
    Patent number: 8609622
    Abstract: C-aryl glucoside derivatives, preparation processes and pharmaceutical uses thereof are disclosed. In particular, C-aryl glucoside derivatives represented by formula (I), with each substituent defined in the application, pharmaceutically acceptable salts or stereoisomers thereof, their preparation methods, and pharmaceutical compositions containing the derivatives as well as their uses as therapeutic agents, particularly as sodium-dependent glucose cotransporter (SGLT)-1 inhibitors, are disclosed.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: December 17, 2013
    Assignees: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Fanglong Yang, Peng Cho Tang, Qing Dong, Wangyang Tu, Jiang Fan, Dongliang Guan, Guangyuan Shen, Yang Wang, Jijun Yuan, Limin Zhang
  • C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF
    Publication number: 20130130997
    Abstract: C-aryl glucoside derivatives, preparation processes and pharmaceutical uses thereof are disclosed. In particular, C-aryl glucoside derivatives represented by formula (I), with each substituent defined in the application, pharmaceutically acceptable salts or stereoisomers thereof, their preparation methods, and pharmaceutical compositions containing the derivatives as well as their uses as therapeutic agents, particularly as sodium-dependent glucose cotransporter (SGLT)-1 inhibitors, are disclosed.
    Type: Application
    Filed: June 30, 2011
    Publication date: May 23, 2013
    Applicants: JIANGSU HENGRUI MEDICINE CO., LTD., SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
    Inventors: Fanglong Yang, Peng Cho Tang, Qing Dong, Wangyang Tu, Jiang Fan, Dongliang Guan, Guangyuan Shen, Yang Wang, Jijun Yuan, Limin Zhang
  • Dicycloazaalkane derivatives, preparation processes and medical uses thereof
    Patent number: 8415349
    Abstract: The invention provides derivatives of azabicyclo alkane having formula (ID), and the method for making them, wherein each substitute in formula (ID) is same as defined in the description.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: April 9, 2013
    Assignee: Jiangsu Hansoh Pharmaceuticals Co., Ltd.
    Inventors: Peng Cho Tang, Zhigang Lin, Hejun Lü, Fuqiang Zhao, Li Li, Fanglong Yang, Jianghong Fu, Lin Wang, Guangyuan Shen, Dongliang Guan
  • DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF
    Publication number: 20130012705
    Abstract: Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Jiangsu Hansoh Pharmaceutical Co., Ltd.
    Inventors: Peng Cho Tang, Zhigang Lin, Hejun Lü, Fuqiang Zhao, Li Li, Fanglong Yang, Jianghong Fu, Lin Wang, Guangyuan Shen, Dongliang Guan
  • Dicycloazaalkane derivates, preparation processes and medical uses thereof
    Patent number: 8304411
    Abstract: Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: November 6, 2012
    Assignees: Jiangsu Hansoh Pharmaceutical Co., Ltd., Shanghai Hengrui Pharmaceutical Co. Ltd.
    Inventors: Peng Cho Tang, Zhigang Lin, Hejun Lu, Fuqiang Zhao, Li Li, Fanglong Yang, Jianghong Fu, Lin Wang, Guangyuan Shen, Dongliang Guan