Abstract: Provided is a fusion protein dimer using an antibody Fc region as the backbone, comprising a first and a second polypeptide chain. The first polypeptide chain comprises a first antibody Fc region and one or more single-domain antibodies fused to the first antibody Fc region. The second polypeptide chain comprises a second antibody Fc region and one or more single domain antibodies fused to the second antibody Fc region. The first polypeptide chain and/or the second polypeptide chain further comprise a cytokine fused to the Fc region of the respective antibody. Further provided is use of the fusion protein dimer in preparing an immunotherapeutic drug for treating tumors. The Fc fusion protein heterodimer not only increases the activity of a single domain antibody, but also significantly improves the biological activity of a cytokine.

Abstract: A display panel includes a main body and binding pins. In an embodiment, the main body includes a display region and a first non-display region. In an embodiment, the display region includes a first display region and a second display region, the first display region and the second display region each includes first signal lines, the first non-display region includes a first connecting line and a second connecting line. In an embodiment, the binding pins are electrically connected to the first signal lines through the first connecting line. In an embodiment, the display region further includes a third connecting line extending from the second display region to the first display region, and the first signal lines in the second display region are electrically connected to the plurality of binding pins through the first connecting line and the second connecting line.

Abstract: Disclosed is an adjustment mechanism for an electric power-driven shoe, the mechanism comprising a shoe sole (1), wherein a plurality of rolling wheels (2) are arranged below the shoe sole (1); a foot-positioning mechanism is arranged above the shoe sole (1) and is provided with an angle-adjusting mechanism for adjusting an angle between the foot-positioning mechanism and a lengthwise direction of the shoe sole (1).

Abstract: The present disclosure relates to cross-device interaction methods and terminal devices. In one example method, a first device determines that a user identity of the first device is the same as a user identity of a second device. The first device obtains a target user of a task being executed by the second device. The first device determines, based on the target user of the task being executed by the second device, that a target contact of an application currently used by the first device is the target user. The first device sends information to the target user.

Abstract: The present application discloses a data read and write method and a distributed storage system. A specific implementation of the method includes: receiving, from a client, by a shard server, a processing request on shard data, the processing request comprising a data identifier of the shard data; processing the processing request based on a hash table pre-loaded in a memory and indicating a correspondence between the data identifier of the shard data and a data index to obtain a processing result; and sending the processing result to the client.

Abstract: A method includes: extracting first structured information from a first screen in response to a first operation performed by a user on the first screen, and generating a first prompt message based on the first structured information; extracting second structured information from a second screen in response to the first operation performed by the user on the second screen; and when the first time and the second time have an intersection, and the first address is different from the second address, automatically changing the first time in the first prompt message, so that a changed first time and the second time have no intersection.

Abstract: A real-time monitoring apparatus for seafloor deformation during hydrate exploitation, includes a main frame, a detecting device, and a sensing and wireless data transmitting device. The detecting device includes at least two detecting straight rods in different directions; the detecting straight rods are connected to the main frame through the movable sleeves; and at least two fixing supports are configured below each detecting straight rod, perpendicular to and uniformly distributed along the detecting straight rod. A movable lever is configured above each detecting straight rod, the movable lever is connected to the main frame through the lever-fixing rod, and a stretchable and compressible spring is configured at an upper end of the movable lever. The sensing and wireless data transmitting device includes at least two tension and compression force sensors in different directions, a gyroscope sensor, a wireless data transmitter, and a power source, all mounted in the main frame.

Abstract: The object is to provide a tumor antigen peptide that is specifically presented on a cancer and a cancer stem cell, and a pharmaceutical composition, etc. that is useful for the prevention and/or treatment of a cancer and contains the above peptide as an active ingredient. The above object has been accomplished by providing a BORIS-derived partial peptide belonging to isoform A or C or subfamily 5 or 6, a polynucleotide encoding the peptide, a pharmaceutical composition containing the above as an active ingredient, and an agent for the prevention and/or treatment of a cancer, the agent containing the above as an active ingredient and inducing CTLs.

Abstract: A method includes: extracting first structured information from a first screen in response to a first operation performed by a user on the first screen, and generating a first prompt message based on the first structured information; extracting second structured information from a second screen in response to the first operation performed by the user on the second screen; and when the first time and the second time have an intersection, and the first address is different from the second address, automatically changing the first time in the first prompt message, so that a changed first time and the second time have no intersection.

Abstract: A real-time monitoring apparatus for seafloor deformation during hydrate exploitation, includes a main frame, a detecting device, and a sensing and wireless data transmitting device. The detecting device includes at least two detecting straight rods in different directions; the detecting straight rods are connected to the main frame through the movable sleeves; and at least two fixing supports are configured below each detecting straight rod, perpendicular to and uniformly distributed along the detecting straight rod. A movable lever is configured above each detecting straight rod, the movable lever is connected to the main frame through the lever-fixing rod, and a stretchable and compressible spring is configured at an upper end of the movable lever. The sensing and wireless data transmitting device includes at least two tension and compression force sensors in different directions, a gyroscope sensor, a wireless data transmitter, and a power source, all mounted in the main frame.

Abstract: A power switching device may include a semiconductor substrate and a body region comprising an n-type dopant, the body region disposed in an inner portion of the semiconductor substrate; a first base layer disposed adjacent a first surface of the semiconductor substrate, the first p-base layer comprising a p-type dopant; a second base layer disposed adjacent a second surface of the semiconductor substrate, the second base layer comprising a p-type dopant; a first emitter region, disposed adjacent the first surface of the semiconductor substrate, the first emitter region comprising a n-type dopant; a second emitter-region, disposed adjacent the second surface of the semiconductor substrate, the second emitter-region comprising a n-type dopant; a first field stop layer arranged between the first base layer and the body region, the first field stop layer comprising a n-type dopant; and a second field stop layer arranged between the second base layer and the body region, the second field stop layer comprising a n

Abstract: The present application discloses a data read and write method and a distributed storage system. A specific implementation of the method includes: receiving, from a client, by a shard server, a processing request on shard data, the processing request comprising a data identifier of the shard data; processing the processing request based on a hash table pre-loaded in a memory and indicating a correspondence between the data identifier of the shard data and a data index to obtain a processing result; and sending the processing result to the client.

Abstract: The object is to provide a tumor antigen peptide that is specifically presented on a cancer and a cancer stem cell, and a pharmaceutical composition, etc. that is useful for the prevention and/or treatment of a cancer and contains the above peptide as an active ingredient. The above object has been accomplished by providing a BORIS-derived partial peptide belonging to isoform A or C or subfamily 5 or 6, a polynucleotide encoding the peptide, a pharmaceutical composition containing the above as an active ingredient, and an agent for the prevention and/or treatment of a cancer, the agent containing the above as an active ingredient and inducing CTLs.

Abstract: A utility lighter having a housing and a spark generator operable to generate a spark generally adjacent an exit opening of the housing. Movement of a trigger from its inoperative position to its operative position in a normal mode of operation of the lighter operates the spark generator to generate a spark. A disabling mechanism is positionable relative to the housing between a first position corresponding to a disabled mode of operation of the lighter in which the lighter is ineffective to generate a spark and a second position corresponding to the normal mode of operation of the lighter. The trigger is movable between its inoperative and operative positions in both the disabled mode and the normal mode of the lighter. In the disabled mode of the lighter the disabling mechanism is adapted to disable the trigger from operating the spark generator in the operative position of the trigger.

Abstract: A utility lighter having a housing and a spark generator operable to generate a spark generally adjacent an exit opening of the housing. Movement of a trigger from its inoperative position to its operative position in a normal mode of operation of the lighter operates the spark generator to generate a spark. A disabling mechanism is positionable relative to the housing between a first position corresponding to a disabled mode of operation of the lighter in which the lighter is ineffective to generate a spark and a second position corresponding to the normal mode of operation of the lighter. The trigger is movable between its inoperative and operative positions in both the disabled mode and the normal mode of the lighter. In the disabled mode of the lighter the disabling mechanism is adapted to disable the trigger from operating the spark generator in the operative position of the trigger.