Patents by Inventor Dongmei Xu

Dongmei Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Producing Tobacco Plants and Products Having Altered Alkaloid Levels with Desirable Leaf Quality
    Publication number: 20190271000
    Abstract: The present disclosure includes methods and compositions for improving leaf quality in low-alkaloid tobacco plants, e.g., by combining inducible promoters and non-coding RNAs for suppression of an ornithine decarboxylase (ODC) gene. Also provided are low alkaloid tobacco plants with normal, suppressed, or otherwise altered polyamine levels. Further provided are tobacco plants with altered total alkaloid, nicotine levels, commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
    Type: Application
    Filed: March 4, 2019
    Publication date: September 5, 2019
    Applicant: Altria Client Services LLC
    Inventors: Marcos Fernando de GODOY LUSSO, James A STRICKLAND, Jesse FREDERICK, Dongmei XU, Chengalrayan KUDITHIPUDI
  • Tobacco Nicotine Demethylase Genomic Clone and Uses thereof
    Publication number: 20190256861
    Abstract: The present invention features tobacco nicotine demethylase nucleic acid and amino acid sequences, tobacco plants and plant components containing such sequences, including tobacco plants and plant components having reduced expression or altered enzymatic activity of nicotine demethylase, methods of use of nicotine demethylase sequences to create plants having altered levels of nornicotine or N-nitrosonornicotine (“NNN”) or both relative to a control plant, as well as tobacco articles having reduced levels of nornicotine or NNN.
    Type: Application
    Filed: February 28, 2019
    Publication date: August 22, 2019
    Inventor: Dongmei Xu
  • COMPOSITIONS AND METHODS FOR PRODUCING TOBACCO PLANTS AND PRODUCTS HAVING ALTERED ALKALOID LEVELS
    Publication number: 20190246596
    Abstract: The present disclosure provides tobacco Nic1b locus and associated genes. Also provided are tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants. Further provided are compositions and methods for producing tobacco plants having novel mutations or alleles to reduce nicotine levels. Further provided are sequence polymorphisms and molecular markers for breeding tobacco with reduced nicotine or alkaloids while maintaining tobacco leaf grade and tobacco product quality.
    Type: Application
    Filed: January 11, 2019
    Publication date: August 15, 2019
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Sreepriya PRAMOD, Marcos Fernando de GODOY LUSSO, Jesse FREDERICK, Andrew Carl ADAMS, Dongmei XU
  • Bacteriophage and methods of making and using
    Patent number: 10377992
    Abstract: Bacteriophage are provided, and methods of making and using the bacteriophage also are provided. The bacteriophage can be provided in a tobacco product, where the bacteriophage reduces the number of viable bacteria in the tobacco product and includes a nucleic acid sequence encoding an endolysin having at least 95% sequence identity to the nucleic acid sequence shown in SEQ ID NO: 1 or to the amino acid sequence shown in SEQ ID NO: 2.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: August 13, 2019
    Assignees: Altria Client Services LLC, Micreos BV
    Inventors: Dongmei Xu, Elisabeth Miller, James Arthur Strickland, Ujwala Warek, Steven Hagens
  • Endolysin from bacteriophage against and methods of using
    Patent number: 10357056
    Abstract: Bacteriophage against Geobacillus are provided, and methods of making and using the bacteriophage also are provided.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: July 23, 2019
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Elisabeth Miller, Ujwala Warek, Dongmei Xu
  • COMPOSITIONS AND METHODS FOR PRODUCING TOBACCO PLANTS AND PRODUCTS HAVING ALTERED ALKALOID LEVELS
    Publication number: 20190216037
    Abstract: The present disclosure provides tobacco Nic1b locus and associated genes (e.g., a group of ERF genes). Also provided are tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants. Further provided are compositions and methods for producing tobacco plants having novel mutations or alleles to reduce nicotine levels. Further provided are sequence polymorphisms and molecular markers for breeding tobacco with reduced nicotine or alkaloids while maintaining tobacco leaf grade and tobacco product quality.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 18, 2019
    Applicant: ALTRIA CLIENT SERVICES LLC
    Inventors: Sreepriya PRAMOD, Marcos Fernando de GODOY LUSSO, Jesse FREDERICK, Andrew Carl ADAMS, Dongmei XU
  • Bacteriophage and Methods of Making and Using
    Publication number: 20190203185
    Abstract: Bacteriophage are provided, and methods of making and using the bacteriophage also are provided.
    Type: Application
    Filed: March 20, 2019
    Publication date: July 4, 2019
    Inventors: Dongmei Xu, Elisabeth Miller, James Arthur Strickland, Ujwala Warek, Steven Hagens
  • Nitrite-Degrading and TSNA-Degrading Bacteria and Methods of Making and Using
    Publication number: 20190200668
    Abstract: Provided herein are bacterial strains that are capable of degrading nitrite and/or TSNAs. Also provided herein are methods of using such bacterial strains to degrade nitrite and/or TSNAs.
    Type: Application
    Filed: January 15, 2019
    Publication date: July 4, 2019
    Applicant: Altria Client Services LLC
    Inventors: Ujwala Warek, Mark T. Nielsen, Dongmei Xu, Mingwu Cui, Xue Luo, Xiaohong Jin, Elisabeth Miller, Kwang Choi
  • Nicotiana Nucleic Acid Molecules and Uses Thereof
    Publication number: 20190194733
    Abstract: The present invention features Nicotiana nucleic acid sequences such as sequences encoding constitutive, or ethylene or senescence induced polypeptides, in particular cytochrome p450 enzymes, in Nicotiana plants and methods for using these nucleic acid sequences and plants to alter desirable traits, for example by using breeding protocols.
    Type: Application
    Filed: March 12, 2019
    Publication date: June 27, 2019
    Applicant: U.S. Smokeless Tobacco Company LLC
    Inventors: Dongmei Xu, Mark T. Nielsen, Yanxin Shen
  • Peroxides to limit biofilms and tobacco-specific nitrosamines
    Patent number: 10306915
    Abstract: Methods of making reconstituted tobacco include contacting a mixture including tobacco pulp with one or more fluid streams including one or more peroxides (e.g., hydrogen peroxide), recovering one or more fluids from the tobacco pulp mixture, and reusing the recovered fluids in at least one subsequent tobacco pulp contacting step. In some cases, methods provided herein can recover one or more fluids including one or more peroxides, such that the at least one subsequent tobacco pulp contacting step includes contacting tobacco pulp with a fluid including one or more peroxides.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: June 4, 2019
    Assignee: Altria Client Services LLC
    Inventors: John Kotrola, Ujwala Warek, James Arthur Strickland, Elisabeth Miller, Dongmei Xu
  • nucleic acid molecules and uses thereof
    Patent number: 10292416
    Abstract: The present invention features Nicotiana nucleic acid sequences such as sequences encoding constitutive, or ethylene or senescence induced polypeptides, in particular cytochrome p450 enzymes, in Nicotiana plants and methods for using these nucleic acid sequences and plants to alter desirable traits, for example by using breeding protocols.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: May 21, 2019
    Assignee: Altria Client Services LLC
    Inventors: Dongmei Xu, Mark T. Nielsen, Yanxin Shen
  • nucleic acid molecules and uses thereof
    Patent number: 10294520
    Abstract: The present invention features Nicotiana nucleic acid sequences such as sequences encoding constitutive, or ethylene or senescence induced polypeptides, in particular cytochrome p450 enzymes, in Nicotiana plants and methods for using these nucleic acid sequences and plants to alter desirable traits, for example by using breeding protocols.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: May 21, 2019
    Assignee: U.S. Smokeless Tobacco Company LLC
    Inventors: Dongmei Xu, Mark T. Nielsen, Yanxin Shen
  • Tobacco nicotine demethylase genomic clone and uses thereof
    Patent number: 10266836
    Abstract: The present invention features tobacco nicotine demethylase nucleic acid and amino acid sequences, tobacco plants and plant components containing such sequences, including tobacco plants and plant components having reduced expression or altered enzymatic activity of nicotine demethylase, methods of use of nicotine demethylase sequences to create plants having altered levels of nornicotine or N?-nitrosonornicotine (“NNN”) or both relative to a control plant, as well as tobacco articles having reduced levels of nornicotine or NNN.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 23, 2019
    Assignee: U.S. Smokeless Tobacco Company LLC
    Inventor: Dongmei Xu
  • Compositions and Methods for Producing Tobacco Plants and Products Having Reduced or Eliminated Suckers
    Publication number: 20190078112
    Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 14, 2019
    Inventors: Dongmei XU, Jesse FREDERICK, Chengalrayan KUDITHIPUDI, Yanxin SHEN, James STRICKLAND, Jaemo YANG
  • Nitrite-degrading and TSNA-degrading bacteria and methods of making and using
    Patent number: 10226064
    Abstract: Provided herein are bacterial strains that are capable of degrading nitrite and/or TSNAs. Also provided herein are methods of using such bacterial strains to degrade nitrite and/or TSNAs.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: March 12, 2019
    Assignee: Altria Client Services LLC
    Inventors: Ujwala Warek, Mark T. Nielsen, Dongmei Xu, Mingwu Cui, Xue Luo, Xiaohong Jin, Elisabeth Miller, Kwang Choi
  • Methods and Compositions Related to Improved Nitrogen Utilization Efficiency in Tobacco
    Publication number: 20190069506
    Abstract: The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 7, 2019
    Applicant: Altria Client Services LLC
    Inventors: Jesse Frederick, Chengalrayan Kudithipudi, Dongmei Xu
  • STABILIZATION METHODS FOR TOBACCO AND TOBACCO PRODUCTS
    Publication number: 20190037910
    Abstract: A stabilizing process for tobacco and tobacco products includes sterilizing the tobacco by applying an electron beam treatment to the tobacco. The process may also include treating the tobacco. The treating the tobacco includes pre-conditioning the tobacco, pasteurizing the tobacco, curing the tobacco, fermenting the tobacco, or combinations thereof. The method may also include forming a smokeless tobacco product containing the tobacco.
    Type: Application
    Filed: August 3, 2018
    Publication date: February 7, 2019
    Applicant: Altria Client Services LLC
    Inventors: Yahya KARGA, James POWELL, Dongmei XU, James A. STRICKLAND, Ujwala WAREK
  • TOBACCO PLANTS HAVING ALTERED AMOUNTS OF ONE OR MORE ALKALOIDS IN LEAF AND METHODS OF USING SUCH PLANTS
    Publication number: 20180199532
    Abstract: This disclosure provides a number of sequences involved in the transport of alkaloids from the root to the leaf in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences, and tobacco products made from such plants.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 19, 2018
    Inventors: Jesse Frederick, Yanxin Shen, Dongmei Xu, Ujwala Warek, James Arthur Strickland
  • Composition and Methods for Producing Tobacco Plants and Products Having Reduced Tobacco-Specific Nitrosamines (TSNAs)
    Publication number: 20180119163
    Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
    Type: Application
    Filed: October 6, 2017
    Publication date: May 3, 2018
    Inventors: Chengalrayan Kudithipudi, Dongmei Xu, James Strickland
  • Tobacco Plants Having Increased Nitrogen Efficiency and Methods of Using Such Plants
    Publication number: 20180098564
    Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.
    Type: Application
    Filed: October 6, 2017
    Publication date: April 12, 2018
    Inventors: Jesse Frederick, Chengalrayan Kudithipudi, Dongmei Xu