Patents by Inventor Dongmei ZHONG

Dongmei ZHONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12173056
    Abstract: Disclosed is an isolated binding protein including a cardiac troponin I (cTnI) antigen binding domain, and preparation and a use and the like of the binding protein. The antigen binding domain includes at least one complementarity determining region selected from an amino acid sequence defined in this article, or has at least 80% sequence identity with the complementarity determining region of the amino acid sequence and has KD?9.96×10?8 mol/L affinity with cTnI. The binding protein may be used in the detection field of the cTnI protein.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: December 24, 2024
    Assignee: FAPON BIOTECH INC.
    Inventors: Peng Cui, Zhiqiang He, Yuan Meng, Dongmei Zhong
  • Publication number: 20240270831
    Abstract: A chimeric immunoglobulin is provided. It is obtained by fusing a first polypeptide and a second polypeptide, wherein the first polypeptide includes an IgG variable region located at the N terminal; and the second polypeptide includes an IgA CH2-CH3 region or an IgM CH3-CH4 region located at the C terminal. The immunoglobulin has higher titer, and when coated in a solid phase, it still has higher titer than that of an IgG monomer with the same valence, so it can be widely applied in the detection field.
    Type: Application
    Filed: March 3, 2022
    Publication date: August 15, 2024
    Inventors: Yuan MENG, Dongmei ZHONG
  • Publication number: 20240158475
    Abstract: Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and comprising specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue virus. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.
    Type: Application
    Filed: August 26, 2019
    Publication date: May 16, 2024
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG
  • Publication number: 20230391853
    Abstract: An antibody against a novel coronavirus, and a reagent and a kit for detecting the novel coronavirus, which relate to the technical field of antibodies. The antibody against the novel coronavirus includes a heavy chain complementarity determinant region and a light chain complementarity determinant region. The antibody has good affinity for N protein of the novel coronavirus, and has good sensitivity and specificity for detecting the novel coronavirus. Antibody options are provided for detection of the novel coronavirus.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 7, 2023
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG, Wenjuan LOU, Lingyun FAN
  • Publication number: 20220033484
    Abstract: Disclosed is an isolated binding protein including a cardiac troponin I (cTnI) antigen binding domain, and preparation and a use and the like of the binding protein. The antigen binding domain includes at least one complementarity determining region selected from an amino acid sequence defined in this article, or has at least 80% sequence identity with the complementarity determining region of the amino acid sequence and has KD?9.96×10?8 mon affinity with cTnI. The binding protein may be used in the detection field of the cTnI protein.
    Type: Application
    Filed: September 27, 2019
    Publication date: February 3, 2022
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG
  • Publication number: 20220025008
    Abstract: The present disclosure relates to a novel isolated binding protein including a N-terminal pro-brain natriuretic peptide (NT-proBNP) antigen binding domain, and the preparation method therefor. The antigen-binding domain includes at least one complementarity determining region selected from the amino acid sequences as defined in the present disclosure: or; has at least 80% sequence identity with the complementarity determining region of the following amino acid sequence and has an affinity of KD?2.26×10?8 to NT-proBNP. The binding protein may be used in the detection field of NT-proBNP protein.
    Type: Application
    Filed: October 1, 2019
    Publication date: January 27, 2022
    Inventors: Yuan MENG, Dongmei ZHONG, Qingni YE, Bi LIANG, Hui YOU, Qiuyan MA, Weizhi LI
  • Publication number: 20220002395
    Abstract: Provided is an anti-Plasmodium falciparum HRP-II antibody or an antigen-binding fragment thereof. The antibody comprises a heavy chain CDR1-3 shown in SEQ ID NO: 1-3 and a light chain CDR1-3 shown in SEQ ID NO: 4-6. Also provided are an application of the antibody and a method for preparing the antibody.
    Type: Application
    Filed: October 15, 2019
    Publication date: January 6, 2022
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG, Lina TANG, Bi LIANG, Hui YOU
  • Publication number: 20210403601
    Abstract: Provided is an isolated binding protein including a Taq DNA polymerase antigen-binding domain. The antigen-binding domain includes at least one complementarity determining region selected from CDR-VH1-3 and CDR-VL1-3, or has at least 80% sequence identity with the complementarity determining region and has an affinity of KD?8.568×10?9 mol/L to the Taq DNA polymerase. The binding protein may be used in the field of molecular detection.
    Type: Application
    Filed: October 1, 2019
    Publication date: December 30, 2021
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG, Hao YANG, Bi LIANG, Hui YOU, Qiuyan MA, Weizhi LI
  • Publication number: 20210395347
    Abstract: Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and including specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue vims. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.
    Type: Application
    Filed: August 26, 2019
    Publication date: December 23, 2021
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG
  • Publication number: 20210395394
    Abstract: Provided are an isolated binding protein including a pan-species-specific plasmodium lactate dehydrogenase antigen binding domain and a preparation method thereof. The antigen binding domain includes at least one complementarity determining region selected from a defined amino acid sequence, or has at least 80% of sequence identity with the complementarity determining region of the following amino acid sequence and an affinity of KD?1.5647×10?9 mol/L with a pan-species-specific plasmodium lactate dehydrogenase, and may identify the pan-species-specific plasmodium lactate dehydrogenase. The binding protein may be applied to the field of detection of plasmodium lactate dehydrogenase proteins.
    Type: Application
    Filed: October 1, 2019
    Publication date: December 23, 2021
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG, Lina TANG, Bi LIANG, Hui YOU
  • Publication number: 20210340231
    Abstract: The present invention provides an isolated binding protein comprising a cTnI antigen binding domain. The antigen binding domain comprises at least one complementarity determining region selected from amino acid sequences defined herein, or has sequence identity of at least 80% to the complementarity determining region of said amino acid sequence and an affinity of KD?1.41×10?9 mol/L to cTnI. The binding protein can be used for detection of cTnI protein.
    Type: Application
    Filed: September 27, 2019
    Publication date: November 4, 2021
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG, Hui YOU, Lingyun FAN
  • Publication number: 20210324054
    Abstract: Provided is an isolated binding protein including an antigen-binding domain that binds to NS1 protein. The isolated binding protein includes specific heavy chain CDRs and light chain CDRs. The binding protein can specifically recognize and bind to NS1, and has relatively high sensitivity and specificity, thereby achieving the detection of dengue virus. Moreover, the binding protein is not required to be produced by inducing hybridoma cells in mouse abdominal cavity, and thus it is simple in production and has more stable antibody function.
    Type: Application
    Filed: August 26, 2019
    Publication date: October 21, 2021
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG
  • Publication number: 20210301000
    Abstract: Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein. The binding protein can identify and bind to the NS1 protein so as to detect dengue virus.
    Type: Application
    Filed: August 26, 2019
    Publication date: September 30, 2021
    Inventors: Peng CUI, Zhiqiang HE, Yuan MENG, Dongmei ZHONG