Patents by Inventor Dongming XING

Dongming XING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR METHODS FOR TREATING CANCERS
    Publication number: 20220235348
    Abstract: Methods for reversing one or more mutations in the telomerase (TERT) promoter are provided and may be used to treat a cancer. In some embodiments, programmable base editing (PBE) is used to correct a mutated TERT promoter (e.g., ?124 C>T, ?228C>T, or ?250C>T to ?124 C, ?228C, or ?250C, respectively) by using a single guide (sg) RNA-guided and deactivated Campylobacter jejuni Cas9-fused adenine base editor (CjABE). These methods can be used to treat a cancer, such as for example glioblastoma multiforme (GBM), in a mammalian subject in vivo.
    Type: Application
    Filed: May 15, 2020
    Publication date: July 28, 2022
    Applicants: Board of Regents, The University of Texas System, Tsinghua University
    Inventors: Zhimin LU, Ronald DEPINHO, Dongming XING