Patents by Inventor Dongpei Wu

Dongpei Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
    Patent number: 7067509
    Abstract: Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, R5, and R6 are as defined herein. Pharmaceutical compositions containing a compound of this invention, as well as methods relating to the use thereof, are also disclosed.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: June 27, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Val Goodfellow, Martin Rowbottom, Brian P Dyck, Junko Tamiya, Mingzhu Zhang, Jonathan Grey, Troy D Vickers, Mehrak Kiankarimi, Warren Wade, Sarah Clough, Joseph Pontillo, Dongpei Wu
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20060122202
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: October 14, 2005
    Publication date: June 8, 2006
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley Dwight, Charles Huang, Fabio Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 7056927
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: June 6, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley J. Dwight, Charles Q. Huang, Fabio C. Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050272733
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: May 4, 2005
    Publication date: December 8, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6951858
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: October 4, 2005
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6921761
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: July 26, 2005
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050075339
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: November 10, 2003
    Publication date: April 7, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050038057
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: July 6, 2004
    Publication date: February 17, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley Dwight, Charles Huang, Fabio Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20040266773
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: April 26, 2004
    Publication date: December 30, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20040162290
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: November 10, 2003
    Publication date: August 19, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6750350
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: June 15, 2004
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6677340
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: January 13, 2004
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6673796
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: January 6, 2004
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Methods and compositions for gene delivery
    Publication number: 20030134420
    Abstract: The present invention provides novel compositions and formulations for delivering anionic compounds, particularly polynucleotides (DNA and RNA), across cellular boundaries (e.g., cellular membranes) either in vivo or in vitro.
    Type: Application
    Filed: August 2, 2002
    Publication date: July 17, 2003
    Inventors: Charles Peter Lollo, Mariusz Banaszczyk, Henry C. Chiou, Dongpei Wu, Patricia M. Mullein, Alison T. Carlo
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20030130282
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: July 10, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20030114455
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: June 19, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20030073693
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: April 17, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom