Abstract: Human skeletal muscle stem cells were generated from facioscapulohumeral muscular dystrophy (FSHD) and healthy control iPSC using a transgene-free skeletal muscle differentiation protocol and production of stable iMyoblasts. Analyses revealed that FSHD and healthy control iMyoblasts are embryonic-like myogenic cells that undergo myotube differentiation ex vivo by growth factor depletion and are efficiently transplantable into the tibialis anterior (TA) muscles of NSG mice, where human muscle under-goes embryonic-to-adult myosin isoform switching. The DUX4 FSHD disease gene maintains its hypomethylated disease state inFSHD iPSC and iMyoblast, and its expression is upregulated during myotube differentiation and in muscle xenografts. Consequently, these iMyoblasts accurately exhibit the molecular pathology of human muscular dystrophies and are useful for the development of drug, gene editing and stem cell therapeutics.

Abstract: The present application discloses a driving method for a display panel, a driving device thereof and a display device. The driving method includes: performing square wave conversion on drive data received by each channel to obtain data line signals, where square wave signals generated by the conversion of different gray scales in the corresponding drive data have an identical high level, and the time of low level output is different.

Abstract: The present application discloses a driving method for a display panel, a driving device thereof and a display device. The driving method includes: performing square wave conversion on drive data received by each channel to obtain data line signals, where square wave signals generated by the conversion of different gray scales in the corresponding drive data have an identical high level, and the time of low level output is different.

Abstract: The present application discloses a driving method for a display panel, a driving device thereof and a display device. The driving method includes: performing square wave conversion on drive data received by each channel to obtain data line signals, where square wave signals generated by the conversion of different gray scales in the corresponding drive data have an identical high level, and the time of low level output is different.

Abstract: The present application discloses a driving method for a display panel, a driving device thereof and a display device. The driving method includes: performing square wave conversion on drive data received by each channel to obtain data line signals, where square wave signals generated by the conversion of different gray scales in the corresponding drive data have an identical high level, and the time of low level output is different.

Abstract: The present application discloses a driving method, a construction method for a compensation table and a display device. The driving method includes steps of: generating a plurality of first gate drive signals and a plurality of second gate drive signals, driving scanning lines to turn on sequentially or non-sequentially in a group of two, and generating corresponding data driving signals to drive corresponding pixels, where the first gate drive signals are output to the first turned-on scanning lines in each group, the second gate drive signals are output to the last turned-on scanning lines in each group, and the high-level duration of the first gate drive signals is T+?t.

Abstract: A display driving method and a display driving device are disclosed. The display driving method includes the steps of: setting an image signal to be inputted, so that when the image signal is driven on a display panel, a first sub-pixel showing a positive polarity is displayed, and other sub-pixels are not displayed; copying the set image signal by the logic board and inputting the set image signal to the display panel; and finally inputting a gate drive signal.

Abstract: The present application discloses a gate driver circuit, a driving method and a display device. The driving method for the gate driver circuit includes steps of receiving a first clock signal and a second clock signal and generating a plurality of first gate drive signals and a plurality of second gate drive signals based on the first clock signal and the second clock signal to drive a plurality of scanning lines, wherein the plurality of scanning lines are grouped in pairs, and the first gate drive signals and the second gate drive signals drive the two scanning lines in each group for scanning charge in a sequential or non-sequential manner; and outputting data driving signals to drive a display panel, where corresponding to the same data line, data driving signals of pixels corresponding to the same group of scanning lines have the same polarity, and data driving signals of pixels corresponding to two adjacent groups of turned-on scanning lines have opposite polarities.

Abstract: The present application discloses a gate driver circuit, a driving method and a display device. The driving method for the gate driver circuit includes steps of receiving a first clock signal and a second clock signal and generating a plurality of first gate drive signals and a plurality of second gate drive signals based on the first clock signal and the second clock signal to drive a plurality of scanning lines, wherein the plurality of scanning lines are gouped in pairs, and the first gate drive signals and the second gate drive signals drive the two scanning lines in each group for scanning. charge in a sequential or non-sequential manner; and outputting data driving signals to drive a display panel, where corresponding to the same data line, data driving signals of pixels corresponding to the same group of scanning lines have the same polarity, and data driving signals of pixels corresponding to two adjacent groups of turned-on scanning lines have opposite polarities.

Abstract: The present application discloses a driving method, a construction method for a compensation table and a display device. The driving method includes steps of: generating a plurality of first gate drive signals and a plurality of second gate drive signals, driving scanning lines to turn on sequentially or non-sequentially in a group of two, and generating, corresponding data driving signals to drive corresponding pixels, where the first gate drive signals are output to the first turned-on scanning lines in each group, the second gate drive signals are output to the last turned-on scanning lines in each group, and the high-level duration of the first gate drive signals is T±?t.

Abstract: The present application discloses a driving method for a display panel, a driving device thereof and a display device. The driving method includes: performing square wave conversion on drive data received by each channel to obtain data line signals, where square wave signals generated by the conversion of different gray scales in the corresponding drive data have an identical high level, and the time of low level output is different.

Abstract: The present application discloses a driving method for a display panel, a driving device thereof and a display device. The driving method includes: performing square wave conversion on drive data received by each channel to obtain data line signals, where square wave signals generated by the conversion of different gray scales in the corresponding drive data have an identical high level, and the time of low level output is different.

Abstract: The present application discloses a driving method for a display panel, a driving device thereof and a display device. The driving method includes: performing square wave conversion on drive data received by each channel to obtain data line signals, where square wave signals generated by the conversion of different gray scales in the corresponding drive data have an identical high level, and the time of low level output is different.

Abstract: The present application discloses a method for detecting a gamma voltage value, a gamma chip, and a computer-readable storage medium, which includes: when the gamma voltage value generated by the gamma chip being not within a preset voltage range, outputting prompt information corresponding to the gamma voltage value to allow detection by a tester.

Abstract: Disclosed are a driving circuit of a display panel, a display apparatus, and a driving method of a display panel, as well as a computer storage medium. The driver circuit includes a sub-pixel unit and a driving line, the driving line is connected to first ends of a plurality of sub-pixel units. The driver circuit further includes a compensation unit, the driving line is defined with the compensation unit. The compensation unit includes: a voltage compensation module, configured to provide a compensation voltage for the output of the driving line; and a switch module, the switch module controlling the voltage compensation module to discharge, when the driving line outputs a signal.

Abstract: The present invention is directed to the filed of gene therapy. In particular, compositions and methods are disclosed that repair gene microduplication mutations by reversion to a wild type sequence. For example, the creation of a double stranded break by a programmable nuclease protein within a microduplication induces the microhomology mediated end joining DNA repair pathway that in the process of DNA repair removes the microduplication mutation and restores the wild type sequence.

Abstract: Disclosed is a method for generating gray-scale voltage of display panel, which includes: generating, by a data source integrate circuit, a preset number of gamma voltages according to a target analog voltage(S10); and generating the gray-scale voltage of the display panel in accordance with each gamma voltage (S20).

Abstract: Disclosed are a driving circuit of a display panel, a display apparatus, and a driving method of a display panel, as well as a computer storage medium. The driver circuit includes a sub-pixel unit and a driving line, the driving line is connected to first ends of a plurality of sub-pixel units. The driver circuit further includes a compensation unit, the driving line is defined with the compensation unit. The compensation unit includes: a voltage compensation module, configured to provide a compensation voltage for the output of the driving line; and a switch module, the switch module controlling the voltage compensation module to discharge, when the driving line outputs a signal.

Abstract: Disclosed is a method for generating gray-scale voltage of display panel, which includes: generating, by a data source integrate circuit, a preset number of gamma voltages according to a target analog voltage(S10); and generating the gray-scale voltage of the display panel in accordance with each gamma voltage (S20).

Abstract: Disclosed are a data transmission method and device, and a computer readable storage medium. The data transmission method includes the following steps: obtaining consecutive duplicate data and repetition number, in data information to be transmitted; replacing the consecutive duplicate data, according to the duplicate data, the repetition number and a preset identifier, to update the data information; and transmitting the updated data information.