Patents by Inventor Dongxing Zha

Dongxing Zha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DUAL SPECIFICITY ANTIBODIES TO HUMAN PD-L1 AND PD-L2 AND METHODS OF USE THEREFOR
    Publication number: 20250059282
    Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.
    Type: Application
    Filed: November 4, 2024
    Publication date: February 20, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Carlo TONIATTI, Bianka PRINZ, Nadthakarn BOLAND, Eric KRAULAND
  • Dual specificity antibodies to PD-L1 and PD-L2 and methods of use therefor
    Patent number: 12187799
    Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: January 7, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael A. Curran, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Carlo Toniatti, Bianka Prinz, Nga Rewa Houston, Eric Krauland
  • Dual specificity antibodies to human PD-L1 and PD-L2 and methods of use therefor
    Patent number: 12134648
    Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: November 5, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael A. Curran, Ashvin R. Jaiswal, Dongxing Zha, Carlo Toniatti, Bianka Prinz, Nadthakarn Boland, Eric Krauland
  • ANTI-TSLPR (CRLF2) ANTIBODIES
    Publication number: 20240360233
    Abstract: The present disclosure provides antibodies and antigen-binding domain compositions capable of binding to thymic stromal lymphopoietin receptor (TSLPR). Also provided are methods of using such antibodies for the treatment of TSLPR-associated cancers (e.g., B-Cell Acute Lymphoblastic Leukemia (B-ALL)). In embodiments, the antibodies are heterodimeric antibodies that bind TSLPR and CD3 epsilon (i.e., anti-TSLPR x anti-CD3e) antibodies.
    Type: Application
    Filed: August 27, 2022
    Publication date: October 31, 2024
    Inventors: Dongxing ZHA, Marina KONOPLEVA, Nitin JAIN, Melinda G. SMITH, Ze TIAN, Jason K. ALLEN, Chunhua SHI, Amin AL-SHAMI, Alex NISTHAL, John R. DESJARLAIS, Seung CHU, Erik PONG
  • Surface display of whole antibodies in eukaryotes
    Patent number: 12084651
    Abstract: Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: September 10, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Bianka Prinz, Natarajan Sethuraman, Dongxing Zha, Stefan Wildt, Piotr Bobrowicz
  • HUMAN PD-L2 ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20240270867
    Abstract: The present disclosure is directed to antibodies binding to PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L2.
    Type: Application
    Filed: March 20, 2024
    Publication date: August 15, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Carlo TONIATTI, Bianka PRINZ, Nadthakarn BOLAND
  • Human PD-L2 antibodies and methods of use therefor
    Patent number: 11976128
    Abstract: The present disclosure is directed to antibodies binding to PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L2.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: May 7, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael A. Curran, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Carlo Toniatti, Bianka Prinz, Nadthakarn Boland
  • HUMAN PD-L1 ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20240043538
    Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.
    Type: Application
    Filed: November 17, 2022
    Publication date: February 8, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Carlo TONIATTI, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Bianka PRINZ, Nadthakarn BOLAND
  • HUMAN PD-L2 ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20230174661
    Abstract: The present disclosure is directed to antibodies binding to PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L2.
    Type: Application
    Filed: March 15, 2019
    Publication date: June 8, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Carlo TONIATTI, Bianka PRINZ, Nadthakarn BOLAND
  • Human PD-L1 antibodies and methods of use therefor
    Patent number: 11525002
    Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: December 13, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael A. Curran, Carlo Toniatti, Ashvin R. Jaiswal, Dongxing Zha, Kui Voo, Bianka Prinz, Nadthakarn Boland
  • SURFACE DISPLAY OF WHOLE ANTIBODIES IN EUKARYOTES
    Publication number: 20210317441
    Abstract: Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.
    Type: Application
    Filed: June 10, 2021
    Publication date: October 14, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Bianka Prinz, Natarajan Sethuraman, Dongxing Zha, Stefan Wildt, Piotr Bobrowicz
  • Surface, anchored FC-bait antibody display system
    Patent number: 11104721
    Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: August 31, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Dongxing Zha, Hussam Hisham Shaheen
  • DUAL SPECIFICITY ANTIBODIES TO PD-L1 AND PD-L2 AND METHODS OF USE THEREFOR
    Publication number: 20210214445
    Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 15, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Carlo TONIATTI, Bianka PRINZ, Nga Rewa HOUSTON, Eric KRAULAND
  • HUMAN PD-L1 ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20210198360
    Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.
    Type: Application
    Filed: October 10, 2018
    Publication date: July 1, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Carlo TONIATTI, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Bianka PRINZ, Nadthakam BOLAND
  • Surface display of whole antibodies in eukaryotes
    Patent number: 11046951
    Abstract: Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: June 29, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Bianka Prinz, Natarajan Sethuraman, Dongxing Zha, Stefan Wildt, Piotr Bobrowicz
  • DUAL SPECIFICITY ANTIBODIES TO HUMAN PD-L1 AND PD-L2 AND METHODS OF USE THEREFOR
    Publication number: 20210139591
    Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.
    Type: Application
    Filed: March 14, 2019
    Publication date: May 13, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Carlo TONIATTI, Bianka PRINZ, Nadthakarn BOLAND, Eric KRAULAND
  • Method for preparing antibodies having improved properties
    Patent number: 10858686
    Abstract: The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: December 8, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Terrance A. Stadheim, Dongxing Zha
  • Surface anchored light chain bait antibody display system
    Patent number: 10577600
    Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: March 3, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Hussam Hisham Shaheen, Dongxing Zha
  • SURFACE DISPLAY OF WHOLE ANTIBODIES IN EUKARYOTES
    Publication number: 20190055546
    Abstract: Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.
    Type: Application
    Filed: October 3, 2018
    Publication date: February 21, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Bianka Prinz, Natarajan Sethuraman, Dongxing Zha, Stefan Wildt, Piotr Bobrowicz
  • SURFACE, ANCHORED FC-BAIT ANTIBODY DISPLAY SYSTEM
    Publication number: 20190040118
    Abstract: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent antibody fragment can be expressed on the surface of the host cell wherein the fragment may be assayed for antigen binding while full antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of use thereof.
    Type: Application
    Filed: September 17, 2018
    Publication date: February 7, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dongxing Zha, Hussam Hisham Shaheen