Abstract: Disclosed herein are pharmaceutical antibody formulations for the treatment of a disease. The pharmaceutical antibody formulations comprise an antibody that binds to Galectin-3 (Gal3) and one or more excipients, diluents, salts, buffers, and the like. Also disclosed herein are sterile vials comprising these pharmaceutical antibody formulations, optionally in a concentrated form that is diluted prior to administration. The pharmaceutical antibody formulations are used to treat a disease such as a neurodegenerative disease, proteopathy, and/or inflammation associated with the aforementioned diseases.

Abstract: The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension applications thereof. By finding the structural domains of the interacting sites of the endothelial cell ion channel complex TRPV4-KCa2.3, a compound with specificity which can act at the two interacting sites is prepared in the present invention. It is found that the compound can enhance the space coupling degree of the TRPV4-KCa2.3 complex and has great significance for the research and development of anti-hypertension drugs.

Abstract: The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension applications thereof. By finding the structural domains of the interacting sites of the endothelial cell ion channel complex TRPV4-KCa2.3, a compound with specificity which can act at the two interacting sites is prepared in the present invention. It is found that the compound can enhance the space coupling degree of the TRPV4-KCa2.3 complex and has great significance for the research and development of anti-hypertension drugs.