Abstract: Provided herein are methods of activating immune response and/or treating cancer in a patient comprising administering to the patient a Gal3:TIM-3 inhibitor that interferes with the interaction between Gal3 and TIM-3, where said inhibitor is administered in an amount sufficient to activate immune response. Also provided are a humanized anti-Gal3 antibodies that can block the interaction between Gal3 and TIM3 and methods of using the anti-Gal3 antibody to treat cancer. Methods for determining if a patient's cancer is suitable for treatment with a Gal3:TIM-3 inhibitor and methods for selecting compounds that can block interaction between Gal3 and TIM-3, activating immune response and/or treating cancer are also provided.

Abstract: The present application discloses a retainer and a bearing. The retainer includes a first ring, a second ring and multiple beams connecting the first ring and the second ring. The multiple beams are spaced apart from each other in a circumferential direction of the retainer and a pocket for accommodating a rolling element of a bearing is defined between adjacent beams. The side surface of the beam in the circumferential direction includes a first pressure slope and a second pressure slope spaced apart from each other, and a recessed surface provided at one or two ends of the pocket of the retainer and extending from the first pressure slope towards a longitudinal centerline of the beam and towards a longitudinal end of the beam. The retainer facilitates bearing assembling, avoids the use of large instruments during the assembling, and reduces damage to various components of the bearing during the assembling.

Abstract: A design method of a multi-zone grouped and light-homogenized Fresnel lens for a concentrating system includes: step 1, designing, according to a basic principle of a Fresnel lens, a planar Fresnel lens; step 2, establishing, according to an optical path characteristic of the concentrating system, an optical path equation of the concentrating system; step 3, determining a differential form of uniform distribution of luminous energy density; and step 4, based on the step 3, calculating design parameters of the multi-zone grouped and light-homogenized Fresnel lens to obtain the multi-zone grouped and light homogenized Fresnel lens.

Abstract: A COT surface thermocouple including a contact type temperature measuring component, a sleeve, a connecting sealing assembly, a clamping sleeve assembly, a temperature measuring component and a junction box is provided. The COT surface thermocouple is arranged on the surface of a furnace tube of an ethylene cracking furnace. The contact type temperature measuring component is completely in contact welding with the surface of the furnace tube. The whole body is in an inclined angle. The contact type temperature measuring component is connected with the sleeve in a way of concentrically welding a counter bore or connecting an internal thread. The sleeve and the contact type temperature measuring component are concentrically connected without bending. The sleeve is formed by splicing two sections and is connected through the connecting sealing assembly to form a sealing cavity.

Abstract: The present disclosure provides a low-temperature-resistant and corrosion-resistant cargo oil tank steel suitable for high-heat-input welding and a manufacturing method therefor. The low-temperature-resistant and corrosion-resistant cargo oil tank steel suitable for high-heat-input welding includes, by weight in percent, 0.04%-0.13% C, 0.10%-0.40% Si, 0.60%-1.30% Mn, 0.005%-0.012% P, S?0.006%, 0.01%-0.05% Al, 0.03%-0.15% Sn, 0.005%-0.020% Nb, 0.005%-0.025% Ti, 0.15%-0.40% Ni, 0.15%-0.50% Cu, 0.10%-0.25% Cr, 0.007%-0.024% Ca and the balance Fe and inevitable impurities. The corrosion-resistant steel provided by the present disclosure is mainly designed for the upper deck and inner bottom plate of a storage and transportation tank of a polar route oil tanker, and the steel has excellent low-temperature toughness and can be welded with large heat input.

Abstract: A wireless charging system and a method for implementing wireless charging are provided. The wireless charging system includes a bearing surface, a guide rail, a wireless charger, and a driver. On the bearing surface there are multiple regions for placing equipment to-be-charged. The guide rail is located under the bearing surface, and includes a first-direction track. The wireless charger is mounted on the first-direction track under the bearing surface. The wireless charger includes a first slider and a charging circuit. The driver is located under the bearing surface, and includes a first driving circuit connected to the first slider, adapted to changing a location of the wireless charger by driving the first slider to move along the first-direction track.

Abstract: Provided are an antibody targeting NKG2A, a preparation method therefor and use thereof. Specifically, provided is a new mouse or humanized monoclonal antibody targeting NKG2A, and a method for preparing the monoclonal antibody. The monoclonal antibody can bind to an NKG2A antigen with high specificity, and has high affinity and significant activities such as anti-tumor activity.

Abstract: Disclosed are a GITR-targeting antibody, a preparation method therefor and the use thereof. In particular, disclosed is a novel GITR-targeting chimeric antibody or a fully humanized monoclonal antibody. Also disclosed is a method for preparing the monoclonal antibody. The monoclonal antibody of the present invention can bind to a GITR antigen with a high specificity, and has a very high affinity and a significant anti-tumor activity or the like.

Abstract: An antibody targeting CD73, a preparation method therefor and a use thereof. The provided monoclonal antibody can bind to a CD73 antigen with high specificity, and has high affinity and significant antitumor activity.

Abstract: Provided are a high-affinity full human monoclonal antibody highly specifically targeting to TIM-3 and a preparation method therefor. The monoclonal antibody has a remarkable antitumor activity, and can be used for preparing a related diagnostic reagent or a pharmaceutical composition preventing or treating diseases related to TIM-3 dysfunction.

Abstract: An antibody targeting CD47, a preparation method therefor and uses thereof. A novel mouse or human-mouse chimeric antibody targeting CD47. A method for preparing the monoclonal antibody. The monoclonal antibody of the present invention can bind CD47 antigen with high specificity, has high affinity and significant activities, such as anti-tumor activity.

Abstract: Disclosed in the present invention are an antibody targeting IL-5, a preparation method therefor and use thereof. In particular, disclosed in the present invention is a novel murine-derived or chimeric monoclonal antibody targeting IL-5. Also disclosed in the present invention is a method for preparing said monoclonal antibody. The monoclonal antibody of the present invention is capable of binding IL-5 antigen with high specificity, has high affinity and can well alleviate a series of asthma symptoms caused by IL-5, thereby achieving the effect of treating asthma.

Abstract: A wireless charging system and a method for implementing wireless charging are provided. The wireless charging system includes a bearing surface, a guide rail, a wireless charger, and a driver. On the bearing surface there are multiple regions for placing equipment to-be-charged. The guide rail is located under the bearing surface, and includes a first-direction track. The wireless charger is mounted on the first-direction track under the bearing surface. The wireless charger includes a first slider and a charging circuit. The driver is located under the bearing surface, and includes a first driving circuit connected to the first slider, adapted to changing a location of the wireless charger by driving the first slider to move along the first-direction track.

Abstract: A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (SRS). The range shifting device can be incorporated into an existing SRS localization system during SRS treatment. The range shifting device is configured to be placed close to the head of a patient during SRS treatment. The range shifting device is comprised of range shifting material. The range shifting device can be a range shifting helmet. The range shifting helmet can include a hollow frame including a plurality of apertures in which inserts made of range shifting material can be inserted.

Abstract: A spot scanning (SS) ion therapy system configured for dynamic trimming of an ion particle pencil beam to reduce the amount of the radiation dosage outside of a target boundary.

Abstract: A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (SRS). The range shifting device can be incorporated into an existing SRS localization system during SRS treatment. The range shifting device is configured to be placed close to the head of a patient during SRS treatment. The range shifting device is comprised of range shifting material. The range shifting device can be a range shifting helmet. The range shifting helmet can include a hollow frame including a plurality of apertures in which inserts made of range shifting material can be inserted.

Abstract: A spot scanning (SS) ion therapy system configured for dynamic trimming of an ion particle pencil beam to reduce the amount of the radiation dosage outside of a target boundary.