Patents by Inventor DONGXU YI

DONGXU YI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12286389
    Abstract: A crystalline form A of 2,2-bis(4-fluorophenyl)-2-phenylacetamide is provided. The crystalline form has good light stability, high temperature stability, and high humidity stability.
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: April 29, 2025
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD
    Inventors: Guobin Ren, Dongxu Yi, Weijie Ji, Jiajun Huang
  • Patent number: 12268689
    Abstract: Disclosed are eutectic form A of Elagolix and pyrimethamine, a preparation method therefor and a use thereof. Using Cu-K? radiation, eutectic form A has characteristic peaks represented by a 2? degree at 8.1±0.2°, 12.2±0.2°, 13.3±0.2° and 21.1±0.2° in an X-ray powder diffraction. Eutectic form A has a high purity, a good light radiation stability, a high temperature stability, a high humidity stability and an accelerated stability, is easy to store, and has a slow moisture absorption under the condition of relatively low humidity, wherein the weight gain of eutectic form A by moisture absorption is not more than 1.08% when the relative humidity increases from 0 to 60% RH. Production conditions for eutectic form A are easy to control, same has a simple preparation process and a stable quality, and is easy to industrially produce on a large-scale.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: April 8, 2025
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Patent number: 12122762
    Abstract: Provided is crystal form A of N,N?-(10,17-dioxo-3,6,21,24-tetraoxa-9,11,16, 18-tetrazohexahexane-1,26-di-yl)bis(4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl) benzene sulfonamide. The crystal form has good light stability, high-temperature stability, and high-humidity stability.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: October 22, 2024
    Assignee: SHENZHEN RENTAI PHARMATECH LTD.
    Inventors: Guobin Ren, Dongxu Yi, Jiajun Huang
  • Patent number: 12122804
    Abstract: A crystal form X of 3?-hydroxy-3?-methyl-21-(4-cyano-1H-pyrazol-1?-yl)-19-nor-5?-pregnan-20-one, a preparation method of said crystal form and an application thereof in preparing a drug for treatment of central nervous system disease.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 22, 2024
    Assignee: SHENZHEN RENTAI PHARMATECH LTD.
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Publication number: 20230249662
    Abstract: A method and device for failure detection of vacuum sensor is disclosure. The method includes: S1: obtaining a first vacuum pressure when a brake pedal is validly stamped; S2: determining whether a braking action by the brake pedal is maintained, wherein next S3 is performed if yes, and a detection is stopped if not; S3: obtaining a second vacuum pressure when the brake pedal is validly released; and S4: determining whether the second vacuum pressure is within a variable range of the first vacuum pressure, wherein the vacuum sensor is determined to have failed if yes; and, the vacuum sensor is determined to have not failed. The disclosure performs a logical control, and determines whether the vacuum sensor is blockage or failure, thus safety in traffic is ensured, and accidents that the braking action fails due to the blockage or failure of the vacuum sensor is avoided.
    Type: Application
    Filed: June 12, 2021
    Publication date: August 10, 2023
    Inventors: Xuan Luo, Weidong Zhang, Dongxu YI, Yang Cui
  • Publication number: 20220169658
    Abstract: Provided are a crystal form of a gonadotropin releasing hormone antagonist, a preparation method therefor, and use thereof. A crystal form C and a crystal form D have high purity, good illumination stability, high temperature stability, and high humidity stability, and have good solubility and low hygroscopicity; the saturation solubility of the crystal form C and the crystal form D is 101.75 ?g/ml and 87.21 ?g/ml, respectively; when the relative humidity is increased from 0 to 50% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 1.76% and 0.73%, respectively; and when the relative humidity is increased from 0 to 90% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 3.43% and 1.61%, respectively. Therefore, the control of a production condition is facilitated, the preparation process is simple, the quality is stable, and large-scale industrial production is easy.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Publication number: 20220169619
    Abstract: Disclosed is crystal form M of the proline hydroxylase inhibitor daprodustat, wherein the X-ray powder diffraction thereof, expressed in 2? angles and using Cu-Ka radiation, has characteristic peaks at 4.7±0.2°, 6.5±0.2°, and 6.8±0.2°. Disclosed are the preparation method for and the use of crystal form M. The crystal form M has good light stability, high temperature stability and high humidity stability, good solubility, and high purity.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Publication number: 20220143019
    Abstract: Disclosed are eutectic form A of Elagolix and pyrimethamine, a preparation method therefor and a use thereof. Using Cu-K? radiation, eutectic form A has characteristic peaks represented by a 20 degree at 8.1±0.2°, 12.2±0.2°, 13.3±0.2° and 21.1±0.2° in an X-ray powder diffraction. Eutectic form A has a high purity, a good light radiation stability, a high temperature stability, a high humidity stability and an accelerated stability, is easy to store, and has a slow moisture absorption under the condition of relatively low humidity, wherein the weight gain of eutectic form A by moisture absorption is not more than 1.08% when the relative humidity increases from 0 to 60% RH. Production conditions for eutectic form A are easy to control, same has a simple preparation process and a stable quality, and is easy to industrially produce on a large-scale.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu Yi, Jiajun Huang
  • Publication number: 20220098230
    Abstract: A crystal form X of 3?-hydroxy-3?-methyl-21-(4-cyano-1H-pyrazol-1?-yl)-19-nor-5?-pregnan-20-one, a preparation method of said crystal form and an application thereof in preparing a drug for treatment of central nervous system disease.
    Type: Application
    Filed: January 31, 2019
    Publication date: March 31, 2022
    Inventors: Guobin Ren, Weijie Ji, Dongxu YI, Jiajun Huang
  • Publication number: 20220033355
    Abstract: A crystal form A of 2-(2, 5-dioxopyrrolidin-1yl)ethyl methyl fumarate has a good light irradiation stability, high-temperature stability and high-humidity stability.
    Type: Application
    Filed: September 28, 2021
    Publication date: February 3, 2022
    Inventors: Guobin REN, Dongxu YI, Weijie JI, Jiajun HUANG
  • Publication number: 20220033347
    Abstract: A crystalline form A of 2,2-bis(4-fluorophenyl)-2-phenylacetamide is provided. The crystalline form has good light stability, high temperature stability, and high humidity stability.
    Type: Application
    Filed: September 28, 2021
    Publication date: February 3, 2022
    Inventors: Guobin REN, Dongxu YI, Weijie JI, Jiajun HUANG
  • Publication number: 20220024897
    Abstract: A 2-(2,4,5-substituted phenylamino) pyrimidine derivative, having the following chemical formula I:
    Type: Application
    Filed: October 11, 2021
    Publication date: January 27, 2022
    Inventors: Junbiao CHANG, Jinfa DU, Kaikai ZHU, Kai WANG, Jianyong LI, Chunxia ZHANG, Dongxu YI
  • Publication number: 20220002333
    Abstract: A crystalline form A of a compound I is a monoclinic system and a space group thereof is p21.
    Type: Application
    Filed: September 15, 2021
    Publication date: January 6, 2022
    Inventors: Junbiao CHANG, Jinfa DU, Dongxu YI
  • Publication number: 20210403450
    Abstract: Provided is crystal form A of N, N?-(10, 17-dioxo-3, 6, 21, 24-tetraoxa-9, 11, 16, 18-tetrazohexahexane-1, 26-di-yl)bis(4-(6, 8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl) benzene sulfonamide. The crystal form has good light stability, high-temperature stability, and high-humidity stability.
    Type: Application
    Filed: September 13, 2021
    Publication date: December 30, 2021
    Inventors: Guobin REN, Dongxu YI, Jiajun HUANG
  • Patent number: 11014890
    Abstract: Forms B and C of (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide are stable under the conditions of light, high temperature and high humidity.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: May 25, 2021
    Assignee: SHENZHEN RENTAI PHARMATECH LTD
    Inventors: Dongxu Yi, Guobin Ren, Jian Ma, Shuhao Wen, Peiyu Zhang, Yang Liu, Xuekun Shi, Jiajun Huang, Yanqi Zhang, Shigang Ruan, Mingjun Yang, Guangxu Sun
  • Publication number: 20200317181
    Abstract: Provided are a vehicle, an electronic parking brake system and a control method thereof. The control method includes: controlling, when the electronic parking brake system is started, an electronic parking clamping force to be equal to a first preset value to perform parking braking on the vehicle; detecting the electronic parking clamping force and a current state of the vehicle; and when detecting that the vehicle moves, adjusting the electronic parking clamping force according to a magnitude relationship between the electronic parking clamping force and the first preset value to perform the parking braking on the vehicle again.
    Type: Application
    Filed: January 19, 2018
    Publication date: October 8, 2020
    Applicant: Guangzhou Automobile Group Co., Ltd.
    Inventors: Jiantao SUN, Zhenwen CHEN, Lang LIU, Dongxu YI, Chunhui PEI
  • Publication number: 20200002282
    Abstract: Forms B and C of (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide are stable under the conditions of light, high temperature and high humidity.
    Type: Application
    Filed: May 3, 2019
    Publication date: January 2, 2020
    Inventors: Dongxu YI, Guobin REN, Jian MA, Shuhao WEN, Peiyu ZHANG, Yang LIU, Xuekun SHI, Jiajun HUANG, Yanqi ZHANG, Shigang RUAN, Mingjun YANG, Guangxu SUN
  • Patent number: 9988355
    Abstract: The invention discloses a form A of mesylate for nicotinamide derivatives and preparation method and application thereof, wherein the XRPD pattern of the form A of mesylate for nicotinamide derivatives has a diffraction peak at 2?=5.34, 10.341, 14.438, 15.841, 17.32, 18.301, 18.68, 19.005, 19.577, 20.26, 21.161, 21.859, 22.379, 23.04, 23.5, 24.177, 24.959, 25.881, 26.641, 27.18, 28.3, 28.999, 29.501, 31.96, 32.258, 33.999, 36.798, 37.38 and 41.297 with the error range of the 2? values being ±0.2. The form A of mesylate for nicotinamide derivatives provided by the present invention has excellent high-temperature stability, high-humidity stability and illumination stability, and it can be applied to drugs for treating advanced non-small cell lung cancers, gastric cancers, liver cancer or breast cancer. It has preferable bioavailability, and meanwhile the provided qualitative and quantitative information has great significance on further study of the efficacy of such solid drugs.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: June 5, 2018
    Assignee: SHANGHAI SUNTRONG BIOTECHNOLOGY CO., LTD.
    Inventors: Yinglu Yu, Jinyao Chen, Dongxu Yi
  • Publication number: 20170183310
    Abstract: The invention discloses a form A of mesylate for nicotinamide derivatives and preparation method and application thereof, wherein the XRPD pattern of the form A of mesylate for nicotinamide derivatives has a diffraction peak at 2?=5.34, 10.341, 14.438, 15.841, 17.32, 18.301, 18.68, 19.005, 19.577, 20.26, 21.161, 21.859, 22.379, 23.04, 23.5, 24.177, 24.959, 25.881, 26.641, 27.18, 28.3, 28.999, 29.501, 31.96, 32.258, 33.999, 36.798, 37.38 and 41.297 with the error range of the 2? values being ±0.2. The form A of mesylate for nicotinamide derivatives provided by the present invention has excellent high-temperature stability, high-humidity stability and illumination stability, and it can be applied to drugs for treating advanced non-small cell lung cancers, gastric cancers, liver cancer or breast cancer. It has preferable bioavailability, and meanwhile the provided qualitative and quantitative information has great significance on further study of the efficacy of such solid drugs.
    Type: Application
    Filed: July 8, 2015
    Publication date: June 29, 2017
    Inventors: YINGLU YU, JINYAO CHEN, DONGXU YI