Patents by Inventor Dongxuan Shen

Dongxuan Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11262365
    Abstract: The present invention relates to a kit for quantitative analysis of glycated hemoglobin (HbA1c), and the kit for quantitative analysis of HbA1c according to the present invention has excellent long-term stability of an enzyme reagent and thus has an effect of easily overcoming the disadvantages of the conventional reagents used in enzyme assays (e.g., storage, accuracy, portability, convenience of use, etc.).
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: March 1, 2022
    Assignee: I-SENS, INC.
    Inventors: Dongxuan Shen, Jihoon Kim, Joo Young Cho, Kap Soo Park, Hyeong Eun Kim, Hyun Kyu Cho, Seok Won Lee, Hakhyun Nam, Geun Sig Cha
  • Publication number: 20190242910
    Abstract: The present invention relates to a kit for quantitative analysis of glycated hemoglobin (HbA1c), and the kit for quantitative analysis of HbA1c according to the present invention has excellent long-term stability of an enzyme reagent and thus has an effect of easily overcoming the disadvantages of the conventional reagents used in enzyme assays (e.g., storage, accuracy, portability, convenience of use, etc.).
    Type: Application
    Filed: August 10, 2017
    Publication date: August 8, 2019
    Inventors: Dongxuan Shen, Jihoon Kim, Joo Young Cho, Kap Soo Park, Hyeong Eun Kim, Hyun Kyu Cho, Seok Won Lee, Hakhyun Nam, Geun Sig Cha
  • Patent number: 9435792
    Abstract: Disclosed is a hemolysis reagent composition for the quantitative analysis of glycated hemoglobin (HbAlc) via an enzymatic method. The hemolysis reagent compositions of the present invention containing a zwitterionic surfactant and a nitrous compound considerably accelerate hemolysis rate due to the presence of the zwitterionic surfactant, and also induce the N-terminal ?-chain of hemoglobin released by hemolysis to be exposed to the outside of the hemoglobin molecule and assists the participation of a greater number of molecules in the reaction, thereby improving reaction sensitivity and reaction rate of the glycated hemoglobin, and the nitrous compound makes the protein structure of the hemoglobin flexibly modified so that the amino acid sequence of the N-terminal ?-chain of hemoglobin can be readily cut off, thereby significantly reducing the entire time required for the measurement and improving the accuracy of the measurement.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: September 6, 2016
    Assignee: I-SENS, INC.
    Inventors: Dongxuan Shen, Joo Young Cho, Kap Soo Park, Geun Sig Cha, Hakhyun Nam
  • Patent number: 9316655
    Abstract: The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which, as the sample cartridge is inserted into the reaction cartridge, a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: April 19, 2016
    Assignee: I-SENS, INC.
    Inventors: Geun Sig Cha, Hakhyun Nam, Dongxuan Shen, Joo Young Cho, Jihoon Kim
  • Publication number: 20150147804
    Abstract: The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which,as the sample cartridge is inserted into the reaction cartridge,a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: Geun Sig CHA, Hakhyun NAM, Dongxuan SHEN, Joo Young CHO, Jihoon KIM
  • Publication number: 20150044764
    Abstract: The present invention relates to a biochemical assay cartridge. More particularly, the present invention provides a biochemical assay cartridge including an insertion-type solution cartridge and a reaction cartridge receiving the insertion-type solution cartridge, in which the solution cartridge is inserted into the reaction cartridge to catch a protruding protection film inducement unit by a latch in the reaction cartridge and thus break the protection film inducement unit and a protection film for sealing a reaction solution storage unit attached to the solution cartridge is automatically detached to discharge the reaction solution from the solution cartridge to the reaction cartridge.
    Type: Application
    Filed: October 24, 2014
    Publication date: February 12, 2015
    Inventors: Guen Sig Cha, Hakhyun Nam, Dongxuan Shen, Joo Young Cho, Kap Soo Park, Jihoon Kim
  • Publication number: 20140370539
    Abstract: Disclosed is a hemolysis reagent composition for the quantitative analysis of glycated hemoglobin (HbAlc) via an enzymatic method. The hemolysis reagent compositions of the present invention containing a zwitterionic surfactant and a nitrous compound considerably accelerate hemolysis rate due to the presence of the zwitterionic surfactant, and also induce the N-terminal ?-chain of hemoglobin released by hemolysis to be exposed to the outside of the hemoglobin molecule and assists the participation of a greater number of molecules in the reaction, thereby improving reaction sensitivity and reaction rate of the glycated hemoglobin, and the nitrous compound makes the protein structure of the hemoglobin flexibly modified so that the amino acid sequence of the N-terminal ?-chain of hemoglobin can be readily cut off, thereby significantly reducing the entire time required for the measurement and improving the accuracy of the measurement.
    Type: Application
    Filed: November 16, 2012
    Publication date: December 18, 2014
    Inventors: Dongxuan Shen, Joo Young Cho, Kap Soo Park, Geun Sig Cha, Hakhyun Nam
  • Publication number: 20060199241
    Abstract: A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the peptide, or the oligonucleotide, thereby forming a co-factor labeled protein, a co-factor labeled peptide, or a co-factor labeled oligonucleotide. The co-factor is adapted to produce an enzymatic signal that is at least one of electrochemically and optically detectable.
    Type: Application
    Filed: November 1, 2005
    Publication date: September 7, 2006
    Inventors: Hyoungsik Yim, Mark Meyerhoff, Dongxuan Shen, Sangyeul Hwang