Abstract: The present disclosure discloses a method for detecting single strand breaks (SSBs) in DNA based on the following steps. First, DNA of interest is fragmented with a method that generates 3? ends that cannot be tailed. Second, the available 3? ends of the fragmented DNA corresponding to the pre-existing breaks are tailed. Third, SSBs are captured and their positions are identified genome-wide based on the following steps: (1) the tailed fragments are linearly amplified using a chimeric 5?-DNA-RNA-3? primer; (2) the products of primer extension are tailed at the 3? ends; (3) the desired products are amplified by PCR with oligonucleotides containing Illumina® adaptor sequences complementary to both tails and subjected to next-generation sequencing (NGS); 4) finally, positions of SSBs are revealed through the analysis of sequencing results.

Abstract: A method and a system for generating single-sideband Raman light for cold atom interferometer through phase modulation are provided. The system includes a laser, an electro-optic modulator (EOM), a local microwave oscillator, a narrow-bandwidth optical-fiber filter, an optical-fiber power amplifier and a frequency doubling crystal. The laser has frequency of ? and is input to the EOM. The local microwave oscillator applies a modulation voltage with frequency of ? to the EOM and generate double-sideband frequency-modulated light with frequencies of ?±n?(n=0,1,2, . . . ). This light is filtered by the narrow-bandwidth optical-fiber filter, which outputs the target frequency light and is successively input to the optical-fiber power amplifier and the frequency doubling crystal and yields the single-sideband Raman light for cold atom interferometer.

Abstract: A single-laser light source system for cold atom interferometers, comprising: a reference light module including a narrow-bandwidth laser and a frequency stabilization module and an optical frequency shift module including a first electro-optic modulator and a first narrow-bandwidth optical-fiber filter. The first electro-optic modulator is connected to the first narrow-bandwidth optical-fiber filter by an optical fiber, and the first electro-optic modulator is connected to the laser by an optical fiber. The first electro-optic modulator receives an initial light from the laser, modulates the initial light by a modulation signal with a preset frequency, and generates sidebands with the preset frequency. The first narrow-bandwidth optical-fiber filter filters the optical signal at the output of the first electro-optic modulator to obtain a frequency-shifted light as the +1-order sideband.

Abstract: A single-laser light source system for cold atom interferometers, comprising: a reference light module including a narrow-bandwidth laser and a frequency stabilization module and an optical frequency shift module including a first electro-optic modulator and a first narrow-bandwidth optical-fiber filter. The first electro-optic modulator is connected to the first narrow-bandwidth optical-fiber filter by an optical fiber, and the first electro-optic modulator is connected to the laser by an optical fiber. The first electro-optic modulator receives an initial light from the laser, modulates the initial light by a modulation signal with a preset frequency, and generates sidebands with the preset frequency. The first narrow-bandwidth optical-fiber filter filters the optical signal at the output of the first electro-optic modulator to obtain a frequency-shifted light as the +1-order sideband.

Abstract: A microphone array-based target voice acquisition method and device, said method comprising: receiving voice signals acquired on the basis of a microphone array (101); determining a pre-selected target voice signal and a direction thereof (102); performing strong directional gain and weak directional gain on the pre-selected target voice signal, so as to obtain a strong gain signal and a weak gain signal (103); performing an endpoint detection on the basis of the strong gain signal, so as to obtain an endpoint detection result (104); and performing endpoint processing on the weak gain signal according to the endpoint detection result, so as to obtain a final target voice signal (105). The present invention can obtain an accurate and reliable target voice signal, thereby avoiding an adverse effect of the target voice quality on subsequent target voice processing.

Abstract: The present disclosure discloses a method for detecting single strand breaks (SSBs) in DNA based on the following steps. First, DNA of interest is fragmented with a method that generates 3? ends that cannot be tailed. Second, the available 3? ends of the fragmented DNA corresponding to the pre-existing breaks are tailed. Third, SSBs are captured and their positions are identified genome-wide based on the following steps: (1) the tailed fragments are linearly amplified using a chimeric 5?-DNA-RNA-3? primer; (2) the products of primer extension are tailed at the 3? ends; (3) the desired products are amplified by PCR with oligonucleotides containing Illumina adaptor sequences complementary to both tails and subjected to next-generation sequencing (NGS); 4) finally, positions of SSBs are revealed through the analysis of sequencing results.

Abstract: A positioning system for global navigational satellite system (GNSS) includes a first receiver to measure a first carrier phase of a carrier signal emitted by a satellite and a second receiver to measure a second carrier phase of the carrier signal emitted by the satellite. The, first carrier phase includes a first carrier phase ambiguity as an unknown integer number of wavelengths of the carrier signal travelled between the satellite and the first receiver. Similarly, the second carrier phase includes a second carrier phase ambiguity as an unknown integer number of wavelengths of the carrier signal travelled between the satellite and the second receiver.

Abstract: A microphone array-based target voice acquisition method and device, said method comprising: receiving voice signals acquired on the basis of a microphone array (101); determining a pre-selected target voice signal and a direction thereof (102); performing strong directional gain and weak directional gain on the pre-selected target voice signal, so as to obtain a strong gain signal and a weak gain signal (103); performing an endpoint detection on the basis of the strong gain signal, so as to obtain an endpoint detection result (104); and performing endpoint processing on the weak gain signal according to the endpoint detection result, so as to obtain a final target voice signal (105). The present invention can obtain an accurate and reliable target voice signal, thereby avoiding an adverse effect of the target voice quality on subsequent target voice processing.

Abstract: A positioning system for global navigational satellite system (GNSS) includes a first receiver to measure a first carrier phase of a carrier signal emitted by a satellite and a second receiver to measure a second carrier phase of the carrier signal emitted by the satellite. The, first carrier phase includes a first carrier phase ambiguity as an unknown integer number of wavelengths of the carrier signal travelled between the satellite and the first receiver. Similarly, the second carrier phase includes a second carrier phase ambiguity as an unknown integer number of wavelengths of the carrier signal travelled between the satellite and the second receiver.