Patents by Inventor Donna Cassidy-Hanley

Donna Cassidy-Hanley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYPEPTIDE EXPRESSION IN CILIATES
    Publication number: 20150240248
    Abstract: This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production of recombinant polypeptides in ciliates.
    Type: Application
    Filed: March 4, 2014
    Publication date: August 27, 2015
    Inventors: Paul COLUSSI, Donna CASSIDY-HANLEY, Theodore G. CLARK
  • Polypeptide expression in ciliates
    Patent number: 8664374
    Abstract: This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production of recombinant polypeptides in ciliates.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: March 4, 2014
    Assignee: Tetragenetics, Inc.
    Inventors: Paul Colussi, Donna Cassidy-Hanley, Theodore G. Clark
  • POLYPEPTIDE EXPRESSION IN CILIATES
    Publication number: 20120129217
    Abstract: This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production of recombinant polypeptides in ciliates.
    Type: Application
    Filed: September 20, 2011
    Publication date: May 24, 2012
    Inventors: Paul Colussi, Donna Cassidy-Hanley, Theodore G. Clark
  • Recombinant expression of heterologous nucleic acids in protozoa
    Patent number: 7326568
    Abstract: The ciliated protozoan Tetrahymena exemplifies a recombinant system for the expression of heterologous nucleic acids, preferably on the plasma membrane surface. Integration of a heterlogous nucleic acid into the ?-tubulin gene, BTU1, of a paclitaxel-sensitive T. thermophila mutant that possesses btu1-IK350M ?-tubulin allele allows screening for transformants using negative selection, as transformants have restored paclitaxel resistance. Transgenic ciliated protozoa of the invention can serve as live vaccines. For example, transgenic Tetrahymena expressing Ichthyophthirius multifiliis i-antigen protein on their surface are effective vehicles for vaccination of freshwater fish against infection by I. multifiliis.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 5, 2008
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jacek Gaertig, Donna Cassidy-Hanley
  • Recombinant expression of heterologous nucleic acids in protozoa
    Publication number: 20050106164
    Abstract: The ciliated protozoan Tetrahymena exemplifies a recombinant system for the expression of heterologous nucleic acids, preferably on the plasma membrane surface. Integration of a heterlogous nucleic acid into the ?-tubulin gene, BTU1, of a paclitaxel-sensitive T. thermophila mutant that possesses btu1-IK350M ?-tubulin allele allows screening for transformants using negative selection, as transformants have restored paclitaxel resistance. Transgenic ciliated protozoa of the invention can serve as live vaccines. For example, transgenic Tetrahymena expressing Ichthyophthirius multifiliis i-antigen protein on their surface are effective vehicles for vaccination of freshwater fish against infection by I. multifiliis.
    Type: Application
    Filed: June 28, 2004
    Publication date: May 19, 2005
    Inventors: Jacek Gaertig, Harry Dickerson, Theodore Clark, Donna Cassidy-Hanley