Patents by Inventor Donna D. Yu

Donna D. Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ERR modulators and uses thereof
    Patent number: 10590056
    Abstract: Disclosed herein, inter alia, are compositions and methods useful for treating non-alcoholic fatty liver diseases.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: March 17, 2020
    Assignee: CITY OF HOPE
    Inventors: Donna D. Yu, Barry M. Forman
  • PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS
    Publication number: 20190077774
    Abstract: Disclosed herein, inter alia, are compositions and methods useful for treating liver diseases and metabolic diseases.
    Type: Application
    Filed: July 18, 2018
    Publication date: March 14, 2019
    Inventors: Donna D. YU, Barry M. Forman, Hongzhi Li
  • ERR MODULATORS AND USES THEREOF
    Publication number: 20180297923
    Abstract: Disclosed herein, inter alia, are compositions and methods useful for treating non-alcoholic fatty liver diseases.
    Type: Application
    Filed: April 11, 2018
    Publication date: October 18, 2018
    Inventors: Donna D. YU, Barry M. FORMAN
  • Method of synthesizing alkylated bile acid derivatives
    Patent number: 8338628
    Abstract: A novel, improved method of synthesizing alkylated bile acid derivatives is provided. Such derivatives include, but are not limited to the active, potent, and selective FXR receptor agonist such as 6-ECDCA and other CA, DCA and CDCA derivatives. The first step of the synthesis selectively oxidates CDCA, CD, or DCA related starting material. An efficient combined deprotonation, trapping, ethylation, deprotection and reduction system is used to produce the desired alkylated bile acid derivatives. This practical synthesis offers a simple and economical pathway suitable for a large-scale manufacturing of alkylated bile acid derivatives including, but not limited to, 6-ECDCA.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: December 25, 2012
    Assignee: City of Hope
    Inventors: Donna D. Yu, Barry M. Forman
  • NOVEL METHOD OF SYNTHESIZING ALKYLATED BILE ACID DERIVATIVES
    Publication number: 20090062526
    Abstract: A novel, improved method of synthesizing alkylated bile acid derivatives is provided. Such derivatives include, but are not limited to the active, potent, and selective FXR receptor agonist such as 6-ECDCA and other CA, DCA and CDCA derivatives. The first step of the synthesis selectively oxidates CDCA, CD, or DCA related starting material. An efficient combined deprotonation, trapping, ethylation, deprotection and reduction system is used to produce the desired alkylated bile acid derivatives. This practical synthesis offers a simple and economical pathway suitable for a large-scale manufacturing of alkylated bile acid derivatives including, but not limited to, 6-ECDCA.
    Type: Application
    Filed: May 22, 2008
    Publication date: March 5, 2009
    Inventors: Donna D. Yu, Barry M. Forman