Patents by Inventor Donna E. Prunkard

Donna E. Prunkard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein C production in non-human transgenic mammals
    Patent number: 5905185
    Abstract: Methods for producing protein C in transgenic non-human mammals are disclosed. The protein C is modified at the two-chain cleavage site between the light and heavy chains of protein C from Lys-Arg to R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 where R.sub.1 through R.sub.4 are individually Arg or Lys. DNA segments encoding modified protein C are introduced into the germ line of a non-human mammals, and the mammal or its female progeny produces milk containing protein C expressed from the introduced DNA segments. The protein C expressed from the introduced DNA segments has anticoagulant activity when activated. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous protein C are also disclosed.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: May 18, 1999
    Assignees: PPL Therapeutics, ZymoGenetics, Inc.
    Inventors: Ian Garner, Ian R. Cottingham, Simon M. Temperley, Donald C. Foster, Cindy A. Sprecher, Donna E. Prunkard
  • Production of fibrinogen in transgenic animals
    Patent number: 5639940
    Abstract: Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A.alpha., B.beta. and .gamma. chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.
    Type: Grant
    Filed: March 3, 1994
    Date of Patent: June 17, 1997
    Assignees: Pharmaceutical Proteins Ltd., ZymoGenetics, Inc.
    Inventors: Ian Garner, Michael L. Dalrymple, Donna E. Prunkard, Donald C. Foster
  • Production of fibrinogen in transgenic animals
    Patent number: RE42704
    Abstract: Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A?, B? and ? chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: September 13, 2011
    Assignee: Pharming Intellectual Property B.V.
    Inventors: Donna E. Prunkard, Donald C. Foster