Patents by Inventor Donna L. Luisi

Donna L. Luisi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions with reduced opalescence
    Patent number: 7744890
    Abstract: Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification methods which monitor and/or reduce the salt concentrations at selected steps are also disclosed.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: June 29, 2010
    Assignee: Wyeth LLC
    Inventors: Pilarin Elizabeth Nichols, Donna L. Luisi
  • Use Of Sucrose To Suppress Mannitol-Induced Protein Aggregation
    Publication number: 20080200656
    Abstract: The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 21, 2008
    Applicant: WYETH
    Inventors: David C. Sek, Nicholas W. Warne, Kin Ho, Donna L. Luisi, Angela Kantor
  • Methods and compositions with reduced opalescence
    Publication number: 20080154023
    Abstract: Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification methods which monitor and/or reduce the salt concentrations at selected steps are also disclosed.
    Type: Application
    Filed: October 12, 2007
    Publication date: June 26, 2008
    Inventors: Pilarin Elizabeth Nichols, Donna L. Luisi