Patents by Inventor Donna L. Mendrick

Donna L. Mendrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MOLECULAR CARDIOTOXICOLOGY MODELING
    Publication number: 20090202995
    Abstract: The present invention includes methods of predicting cardiotoxicity of test agents and methods of generating cardiotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents.
    Type: Application
    Filed: August 28, 2006
    Publication date: August 13, 2009
    Inventors: Donna L. Mendrick, Kory R. Johnson
  • PRIMARY RAT HEPATOCYTE TOXICITY MODELING
    Publication number: 20090197258
    Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
    Type: Application
    Filed: March 6, 2008
    Publication date: August 6, 2009
    Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Brandon Higgs, Arthur L. Castle, Michael Orr, Michael R. Elashoff
  • Primary rat hepatocyte toxicity modeling
    Patent number: 7469185
    Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: December 23, 2008
    Assignee: Ocimum Biosolutions, Inc.
    Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Brandon Higgs, Arthur L. Castle, Michael Orr, Michael R. Elashoff
  • Molecular cardiotoxicology modeling
    Patent number: 7447594
    Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: November 4, 2008
    Assignee: Ocimum Biosolutions, Inc.
    Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
  • Molecular toxicology modeling
    Publication number: 20080215250
    Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
    Type: Application
    Filed: April 30, 2007
    Publication date: September 4, 2008
    Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Arthur L. Castle, Michael R. Elashoff
  • Molecular toxicology modeling
    Publication number: 20020119462
    Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
    Type: Application
    Filed: July 31, 2001
    Publication date: August 29, 2002
    Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Arthur L. Castle, Michael R. Elashoff