Patents by Inventor Donna Le

Donna Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P70S6 Kinase Modulators And Method Of Use
    Publication number: 20070208020
    Abstract: The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
    Type: Application
    Filed: October 22, 2004
    Publication date: September 6, 2007
    Inventors: Wei Cheng, Erick Co, Moon Kim, Rhett Klein, Donna Le, Amy Suhako, John Nuss, Wei Xu
  • Human adam-10 inhibitors
    Publication number: 20060199820
    Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
    Type: Application
    Filed: June 11, 2003
    Publication date: September 7, 2006
    Inventors: Lynne Bannen, Erick Co, Vasu Jammalamadaka, John Nuss, Moon Hwan Kim, Donna Le, Amy Lew, Morrison Mac, Shumeye Mamo, Richard Khoury, Zhaoyang Wen, Wei Xu
  • Human adam-10 inhibitors
    Publication number: 20050227973
    Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.
    Type: Application
    Filed: December 13, 2002
    Publication date: October 13, 2005
    Inventors: S. Brown, Lynne Canne-Bannen, Erick Co, Vasu Jammalamadaka, Rickard Khoury, Moon Kim, Donna Le, Amy Tsuhako, Morrison Mac, Shumeye Mamo, John Nuss, Michael Prisbylla, Wei Xu